1977
DOI: 10.1016/s0016-5085(19)32274-7
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Influence of Isoproterenol and Cholestyramine on Acute Gastric Mucosal Ulcerogenesis

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Cited by 83 publications
(15 citation statements)
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“…In the last part of the present work it was found that salbutamol elicited a two fold increase in gastric mucosal blood flow in anaesthetized rats. This result is in agreement with those obtained for isoprenaline in both conscious and anaesthetized animals (Curwain & Holton, 1972;Curwain et al, 1974;Ar-chibald et al, 1974;Reed & Smy, 1976;Ritchie & Shearburn, 1977). By contrast, it has recently been reported that P2-agonists do not significantly affect mucosal blood flow in Shay rats (Bernardini, Del Tacca, Martinotti & Soldani, 1980) although this may be due to the method used (aminopyrine) which seems unsuitable for small animals (Main & Whittle, 1972).…”
Section: Discussionsupporting
confidence: 88%
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“…In the last part of the present work it was found that salbutamol elicited a two fold increase in gastric mucosal blood flow in anaesthetized rats. This result is in agreement with those obtained for isoprenaline in both conscious and anaesthetized animals (Curwain & Holton, 1972;Curwain et al, 1974;Ar-chibald et al, 1974;Reed & Smy, 1976;Ritchie & Shearburn, 1977). By contrast, it has recently been reported that P2-agonists do not significantly affect mucosal blood flow in Shay rats (Bernardini, Del Tacca, Martinotti & Soldani, 1980) although this may be due to the method used (aminopyrine) which seems unsuitable for small animals (Main & Whittle, 1972).…”
Section: Discussionsupporting
confidence: 88%
“…The results obtained in the anaesthetized rat, apart from illustrating the divergent effects of Padrenoceptor agonists on gastric acid secretion and mucosal blood flow, suggest that the anti-ulcer effect of salbutamol may be due to its action on mucosal blood flow, a conclusion also reached by other authors (Ritchie & Shearburn, 1977;Johnston & McIsaac, 1980) in studying experimental canine gastritis.…”
Section: Discussionsupporting
confidence: 61%
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“…Among other physiologic variables, gastric mucosal blood flow is believed to be involved in the pathogenesis of gastriculceration (8,12,13). Gastric mucosal blood flow might also play a role in the repair of damaged tissue, and thus in the healing of gastric ulcer (13).…”
mentioning
confidence: 99%
“…Most of the agents used here also mediate changes in gastric mucosal blood flow. It has been shown that mucosal ischaemia will exacerbate the effect of intraluminally applied damaging drugs and that this effect may be reversed by increasing mucosal blood flow (Ritchie, 1975;Ritchie & Shearburn, 1977;Guth & Ballard, 1981). However, while it is possible that the agents used here did affect the gastric vasculature, there is reason to suggest that the effect of these agents on gastric mucosal blood flow was not a factor in their action on gastric mucosal integrity.…”
Section: Resultsmentioning
confidence: 88%