Influence of Isoproterenol and Cholestyramine on Acute Gastric Mucosal Ulcerogenesis

Ritchie, Wallace P.; Shearburn, Edwin W.

doi:10.1016/s0016-5085(19)32274-7

Cited by 83 publications

(15 citation statements)

References 8 publications

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“…In the last part of the present work it was found that salbutamol elicited a two fold increase in gastric mucosal blood flow in anaesthetized rats. This result is in agreement with those obtained for isoprenaline in both conscious and anaesthetized animals (Curwain & Holton, 1972;Curwain et al, 1974;Ar-chibald et al, 1974;Reed & Smy, 1976;Ritchie & Shearburn, 1977). By contrast, it has recently been reported that P2-agonists do not significantly affect mucosal blood flow in Shay rats (Bernardini, Del Tacca, Martinotti & Soldani, 1980) although this may be due to the method used (aminopyrine) which seems unsuitable for small animals (Main & Whittle, 1972).…”

Section: Discussionsupporting

confidence: 88%

“…The results obtained in the anaesthetized rat, apart from illustrating the divergent effects of Padrenoceptor agonists on gastric acid secretion and mucosal blood flow, suggest that the anti-ulcer effect of salbutamol may be due to its action on mucosal blood flow, a conclusion also reached by other authors (Ritchie & Shearburn, 1977;Johnston & McIsaac, 1980) in studying experimental canine gastritis.…”

Section: Discussionsupporting

confidence: 61%

“…0007-1188/82/080587-08 $01.00 immobilization, indomethacin or reserpine in rats (Fielding, Router & Curwain, 1975;Kdkes-Szab6, 1976). Furthermore, these agents have been shown to reduce the hydrogen ion back diffusion induced by salicylates in exteriorized segments of canine gastric mucosa (McGreevy & Moody, 1977;Ritchie & Shearburn, 1977). In contrast, Hano, Bugajski & Danak (1977) in rats and Djahanguiri, Sadeghi, Hemati, Pousti & Firouzabadi (1968) in guinea-pigs, found that isoprenaline was ineffective in protecting the animals against the ulcerogenic effects of stress and histamine, respectively.…”

Section: Introductionmentioning

confidence: 99%

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Effects of Β‐adrenoceptor Drug Stimulation on Various Models of Gastric Ulcer in Rats

Esplugues

Lloris

Martí-Bonmatí

et al. 1982

British J Pharmacology

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1 Experiments were designed to evaluate the effect of the pharmacological activation of fadrenoceptors on various models of gastric ulcer in the rat.2 Pretreatment with the P-adrenoceptor stimulant drugs, isoprenaline or salbutamol, significantly inhibited stress-induced gastric ulcers. This anti-ulcer effect was abolished by propranolol but not by atenolol, suggesting that P2-adrenoceptors mediate this response.3 In the pylorus-ligation model, salbutamol inhibited lesion formation and reduced the intragastric content of hydrogen ions, histamine and pepsin although the latter was only affected with the higher dose of salbutamol.4 Salbutamol also prevented the ulcerogenic action on the gastric mucosa of an exogenously perfused artificial gastric juice, showing that the anti-ulcer effect is not necessarily dependent on acid inhibition. 5 Salbutamol also reduced the formation of acute ulcers induced by various iatrogenic means (histamine, polymyxin B, reserpine and indomethacin). 6 Long-term treatment with salbutamol accelerated the healing of experimental chronic gastric ulcer.7 In anaesthetized rats, salbutamol produced a dose-related increase in mucosal blood flow which may contribute to its mode of action.8 It is concluded that P-adrenoceptor agonists exert preventive and curative effects on gastric damage induced in the rat. This effect seems specific and mediated through P-adrenoceptor activation.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionsupporting

confidence: 61%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of Β‐adrenoceptor Drug Stimulation on Various Models of Gastric Ulcer in Rats

Esplugues

Lloris

Martí-Bonmatí

et al. 1982

British J Pharmacology

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“…Among other physiologic variables, gastric mucosal blood flow is believed to be involved in the pathogenesis of gastriculceration (8,12,13). Gastric mucosal blood flow might also play a role in the repair of damaged tissue, and thus in the healing of gastric ulcer (13).…”

mentioning

confidence: 99%

Effects of Omeprazole on Gastric Mucosal Blood Flow in the Conscious Rat

Mattsson¹,

Larsson²

1987

Scandinavian Journal of Gastroenterology

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Regional blood flow in the gastrointestinal tract (forestomach, corpus, antrum, duodenum, jejunum, and colon) was determined in the conscious rat by means of the microsphere technique. The effects on blood flow were determined after omeprazole (orally and intravenously) and cimetidine (intravenously) during both basal and pentagastrin-stimulated gastric acid secretion. Under basal conditions neither omeprazole nor cimetidine decreased the blood flow in the gastrointestinal tract in spite of pronounced inhibition of acid secretion. On the contrary, there was a tendency towards an increased blood flow in the mucosal layer of the corpus after the oral (80 mumol/kg) and the high intravenous (10 mumol/kg) dose of omeprazole. When omeprazole was given intravenously to rats during pentagastrin-stimulated acid secretion, blood flow in the gastric mucosa was unaffected in spite of complete or almost complete inhibition of acid secretion. In contrast, cimetidine decreased the mucosal blood flow, indicating that the pentagastrin-induced increase in blood flow to some extent is mediated by H2 receptors.

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“…Most of the agents used here also mediate changes in gastric mucosal blood flow. It has been shown that mucosal ischaemia will exacerbate the effect of intraluminally applied damaging drugs and that this effect may be reversed by increasing mucosal blood flow (Ritchie, 1975;Ritchie & Shearburn, 1977;Guth & Ballard, 1981). However, while it is possible that the agents used here did affect the gastric vasculature, there is reason to suggest that the effect of these agents on gastric mucosal blood flow was not a factor in their action on gastric mucosal integrity.…”

Section: Resultsmentioning

confidence: 88%

The effect of adrenergic, cholinergic and peptidergic salivary stimulants on gastric mucosal integrity in the rat.

Soper¹,

Tepperman²

1986

The Journal of Physiology

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SUMMARY1. Sialoadenectomized and sham-operated rats were given salivary secretary stimulants 30 min prior to intragastric instillation of a bile salt solution (5 mM-sodium taurocholate in 100 mM-HCl).2. Administration of the ac-agonist phenylephrine (015-15 mg/kg) resulted in a dose-dependent reduction in the loss of H+ and the intraluminal appearance of Na+ and K+ associated with bile-salt-induced damage to the stomach in the shamsialoadenectomized rat. The effect was not apparent if the salivary glands had been previously excised.3. Adrenaline (0-8-4 0 mg/kg) and noradrenaline (0-8-4-0 mg/kg) were less effective in reducing the degree of mucosal damage in sham-sialoadenectomized rats and were not effective in sialoadenectomized rats.4. Administration of secretary stimulant doses of isoprenaline (5 mg/kg), pilocarpine (2 mg/kg) and substance P (25 mg/kg) either had no significant effect or exacerbated the net transmucosal fluxes of H+, Na+ and K+ associated with bile salt damage to the gastric mucosa.5. The protective action of phenylephrine in sham-sialoadenectomized rats was reversed by prior treatment with the a-antagonist, phentolamine (2 mg/kg). The effect of phentolamine was dose dependent.6. Vagotomy abolished the protective influence of phenylephrine in shamsialoadenectomized rats but did not influence the response to other salivary secretary stimulants consistently.7. These data suggest that stimulation of ox-adrenergic receptors in rat salivary tissue is associated with an amelioration ofthe increase in gastric mucosal permeability to H+, Na+ and K+ in response to an intraluminal bile salt solution. The apparent protective influence of a-adrenergic receptor activation in sham-sialoadenectomized rats is mediated in part by the vagus nerve.

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Influence of Isoproterenol and Cholestyramine on Acute Gastric Mucosal Ulcerogenesis

Cited by 83 publications

References 8 publications

Effects of Β‐adrenoceptor Drug Stimulation on Various Models of Gastric Ulcer in Rats

Effects of Β‐adrenoceptor Drug Stimulation on Various Models of Gastric Ulcer in Rats

Effects of Omeprazole on Gastric Mucosal Blood Flow in the Conscious Rat

The effect of adrenergic, cholinergic and peptidergic salivary stimulants on gastric mucosal integrity in the rat.

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