Influence of isomery in drug release from poly(butyl monoitaconate‐ co ‐acrylamide) hydrogels

The swelling behavior of poly(acrylic acid‐co‐itaconic acid)/NaOH hydrogel as well as its ability for iron and copper rust removal was studied and established for the first time. Through an experimental design, the influence of the synthesis parameters on hydrogel response was determined. It was found that pH‐responsiveness dependence of hydrogel determines its application. In alkaline media, the hydrogel acted as superabsorbent, while in acidic, the most outstanding property was its pickling capability that allowed to clean carbon steel and copper metallic surfaces. Infrared, thermogravimetry, and scanning electron microscopy were performed to determine copolymer formation, thermal properties, and morphology. Metallic crystallographic phases formed during the corrosion processes were determined by X‐ray diffractometer. Hydrogel adhesiveness followed by diffusion and dissolution of metal oxides species was identified as the main steps in the rust removal mechanism. This method offers a new, environmentally friendly perspective to eliminate corrosion from metallic surfaces compared with traditional strategies. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48403.

Section: Evaluation Of Swelling and Removal Properties Of Metal Oxidesmentioning

confidence: 83%

Tuning the pH‐responsiveness capability of poly(acrylic acid‐co‐itaconic acid)/NaOH hydrogel: Design, swelling, and rust removal evaluation

Olvera‐Sosa

Guerra‐Contreras

Gómez‐Durán

et al. 2019

“…To elucidate the mechanism of fluid diffusion into the polymer matrix during hydrogel swelling in protein solution, the diffusion exponents n were estimated using Ritger‐Peppas equation:

\frac{M_{t}}{M_{0}} = k t^{n}

where M t and M 0 are the amount of water absorbed by the hydrogel at time t and at equilibrium, respectively, k is a characteristic constant of the system, and n is a characteristic exponent of the mode of water transport . The value of the diffusion exponent n has been shown to be dependent on the rates of liquid diffusion into the polymer matrix and polymer relaxation . If n = 0.5 the case corresponds to the Fickian diffusion‐controlled mechanism (where the rate of water diffusion is lower than the rate of relaxation of the polymer chain); if 0.50 < n < 1, the non‐Fickian diffusion takes place (when the water diffusion and chain relaxation rates are comparable); if n < 0.5, the case is regarded as Fickian diffusion (but “less Fickian” when the water penetration rate is much below the polymer chain relaxation rate).…”

Section: Resultsmentioning

confidence: 99%

Hydrogels based on copolymers of 2‐hydroxyethylmethacrylate and 2‐hydroxyethylacrylate as a delivery system for proteins: Interactions with lysozyme

Hackl

Khutoryanskiy

Ermolina

2017

Hydrogels have attracted considerable attention due to numerous applications, in particular as contact lenses and carriers for sustained drug delivery. The aim of the present work is to characterize the interactions of copolymer hydrogels consisted of 2hydroxyethylmethacrylate (HEMA) and 2-hydroxyethylacrylate (HEA) with a small protein (lysozyme) and to assess the potential applications of these hydrogels as a drug delivery system for sustained release of protein-based therapeutics. Physicochemical properties of protein-loaded hydrogels, as well as lysozyme in vitro loading and release and the conformation of the protein released from hydrogels were studied. The effect of copolymer composition on the protein deposition on hydrogels and protein aggregation in the presence of hydrogels was also assessed. The results show that introduction of HEA into the copolymeric hydrogels enhances their suitability as a delivery system for proteins. Copolymerisation of HEMA and HEA allows controlling the physicochemical properties of hydrogels and the protein release rate.Recently we described the hydrogels prepared by free-radical threedimensional copolymerisation of 2-hydroxyethylmethacrylate (HEMA) and 2-hydroxyethylacrylate (HEA). 16,17 We have demonstrated that introduction of hydrophilic HEA significantly changes the morphology and the physicochemical properties of the HEA-HEMA hydrogels. In order to evaluate the HEA-HEMA hydrogels as potential drug delivery systems for sustained release of large biopharmaceuticals, the interaction of hydrogel networks with a Additional Supporting Information may be found in the online version of this article.

“…For the determination of the swelling rate and equilibrium (maximal achievable) water content in the hydrogel, considering that the swelling kinetics conforms to the second-order equation, the following equation was applied 41 :…”

Section: Discussionmentioning

confidence: 99%

Synthesis of reactive copolymers with peroxide functionality for cross‐linking water‐soluble polymers

Serdiuk

Shevchuk

Kovalenko

et al. 2022

A series of reactive copolymers with peroxide functionality (RCPFs) were synthesized via radical copolymerization of monomer mixtures in an organic solvent comprised of a peroxide monomer 5-(tert-butyl peroxy)-5-methylhex-1-en-3-yne, acrylamide, maleic anhydride, and butyl methacrylate. Peroxide functionality allows the RCPFs to initiate a variety of radical processes, including cross-linking of organic polymers. Hydrophilic monomer subunits (acrylamide and maleic anhydride) within the RCPF macromolecules promote cross-linking of water-soluble polymers. We aimed to investigate RCPF comonomer ratio and its effects on copolymerization kinetics and composition, as well as physico-chemical and colloidal properties. We also evaluated and characterized the kinetic parameters of the thermal decomposition of peroxide moieties in the synthesized RCPF. Findings revealed that RCPF possessed surface-active properties and reduced surface tension at its aqueous solutionair interface. The data indicated that the decomposition process complied with the first-order kinetics, and complex thermal analysis confirmed the presence of peroxide moieties. RCPFs' ability to cross-link water-soluble polymers was demonstrated on poly(acrylamide) and poly(vinyl alcohol).