Influence of Isoflavone Intake and Equol-producing Intestinal Flora on Prostate Cancer Risk

Sugiyama, Yukiko; Masumori, Naoya; Fukuta, Fumimasa; Yoneta, Akihiro; Hida, Tokimasa; Yamashita, Toshiharu; Minatoya, Machiko; Nagata, Yasunobu; Mori, Mitsuru; Tsuji, Hirokazu; Akaza, Hideyuki; Tsukamoto, Taiji

doi:10.7314/apjcp.2013.14.1.1

Cited by 47 publications

(37 citation statements)

References 21 publications

(28 reference statements)

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“…The proportion of equol-producer varies from 30% to 60%, and is higher among Asians and the elderly (Akaza et al, 2004;Fujimoto et al, 2008). Equol-producing intestinal flora have been reported in vitro human fecal culture (Setchell et al, 2010;Sugiyama et al, 2013). A new equol-producing bacterium, Slackia sp.…”

Section: Introductionmentioning

confidence: 99%

Counts of Slackia sp. strain NATTS in Intestinal Flora are Correlated to Serum Concentrations of Equol both in Prostate Cancer Cases and Controls in Japanese Men

Sugiyama¹,

Nagata²,

Fukuta³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: Isoflavones, which are included in soybeans, have been suggested to protect against prostate cancer. Equol, one of isoflavones, is an intestinally derived bacterial metabolite of daidzein. A newly identified equol-producing bacterium, Slackia sp. strain NATTS, with a high equol-producing activity was isolated from human feces in Japanese adults. Counts of Slackia sp. strain NATTS in intestinal flora have not been assessed with regard to prostate cancer risk. In this study, we investigated the association of serum isoflavones and counts of Slackia sp. strain NATTS with prostate cancer risk in a case-control study. Materials and Methods: Concentrations of isoflavones and counts of Slackia sp. strain NATTS in feces were measured from 44 patients with prostate cancer and 28 hospital controls. The risk of prostate cancer was evaluated in terms of odds ratios (ORs) and 95% confidence intervals (CIs) by the logistic regression analysis. Results: The detection proportions of Slackia sp. strain NATTS in cases and controls were 34.1% and 25.0%, respectively. Counts of Slackia sp. strain NATTS were significantly correlated with serum concentrations of equol both in cases and controls (Spearman correlation coefficients, r s =0.639 and r s =0.572, p<0.01, respectively). Serum concentrations of genistein, daidzein, glycitein, and equol were not significantly associated with risk of prostate cancer. Conclusions: This study found that counts of Slackia sp. strain NATTS correlated with serum concentrations of equol both in prostate cancer cases and controls, but serum isoflavone concentrations were not associated with risk of prostate cancer in our patients.

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Section: Introductionmentioning

confidence: 99%

Counts of Slackia sp. strain NATTS in Intestinal Flora are Correlated to Serum Concentrations of Equol both in Prostate Cancer Cases and Controls in Japanese Men

Sugiyama¹,

Nagata²,

Fukuta³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…After consuming soy products, up to 80% of Asians produce equol in contrast to only 30-40% of Western populations (Lampe et al, 1998;Morton et al, 2002). There is increasing evidence that the clinical efficacy of isoflavone may be affected by equol-producing status (Shor et al, 2012;Minatoya et al, 2013;Sugiyama et al, 2013). A large intervention study is necessary to verify the effect of isoflavone and equol.…”

Section: Isoflavone and Epidemiologic Studiesmentioning

confidence: 99%

Isoflavones: Chemistry, Analysis, Functions and Effects on Health and Cancer

2014

Asian Pacific Journal of Cancer Prevention

118

100

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“…However, a study by Perabo et al (15) reported no convincing clinical proof or evidence that genistein may be beneficial in prostate cancer therapy. Between 2008 and 2012, five out of six studies reported a significant association of isoflavones with a decreased risk of prostate cancer (16), two of which consistently demonstrated that daidzein converted to equol by intestinal bacteria leads to a significantly reduced risk of prostate cancer (16).…”

Section: Effects Of Soy Isoflavones On Cancermentioning

confidence: 99%

Soy isoflavone: The multipurpose phytochemical (Review)

Wang¹,

Ge²,

et al. 2013

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Abstract. Soy isoflavones are compounds found in soybean and soybean products. They have been reported to possess numerous physiological properties, such as antitumor, antimenopausal (female) osteoporosis and anti-aging. They have also been reported to improve learning and memory skills in menopausal women and aid in the prevention and treatment of heart disease, diabetes and Kawasaki disease (KD). In this review, the effects of soy isoflavones on various diseases were analyzed. Based on the analysis, it was hypothesized that the function of soybean isoflavones in the prevention and treatment of various diseases results from their phytoestrogen and antioxidant properties. However, due to their phytoestrogen properties, it is recommended that the risks of soy isoflavone intake as food and̸or medical treatment be further evaluated.

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Influence of Isoflavone Intake and Equol-producing Intestinal Flora on Prostate Cancer Risk

Cited by 47 publications

References 21 publications

Counts of Slackia sp. strain NATTS in Intestinal Flora are Correlated to Serum Concentrations of Equol both in Prostate Cancer Cases and Controls in Japanese Men

Counts of Slackia sp. strain NATTS in Intestinal Flora are Correlated to Serum Concentrations of Equol both in Prostate Cancer Cases and Controls in Japanese Men

Isoflavones: Chemistry, Analysis, Functions and Effects on Health and Cancer

Soy isoflavone: The multipurpose phytochemical (Review)

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