Influence of ischemia-reperfusion injury on rejection after liver transplantation

Prolonged Cold Ischemia Does Not Trigger Lethal Rejection or Accelerate the Acute Rejection in Two Allogeneic Rat Liver Transplantation Models

“…Clinical studies vary in respect to the length of CI time, the type of preservation solution, and the surgical manipulation, and experimental studies vary in respect to the type of tolerance model and the length of CI time. Pirenne [6] and Piratvisuth [11] reported a positive correlation between the incidence of AR and postoperative level of liver enzymes. The elevation of liver enzymes may better reflect the total damage applied on the liver graft consisting of manipulation, preservation, warm and cold ischemia, and reperfusion injury.…”

“…Not mentioned The severity of IRI was associated with the rejection after operation [6]. 1996 Vix et al DDLT 133 960 6 330 min versus 540 6 78 min There were no significant differences in incidence of AR between long cold ischemia and short cold ischemia time [12].…”

“…Four independent clinical retrospective investigations revealed that prolonged cold preservation or severe ischemia reperfusion injury (IRI) were associated with a higher incidence of acute liver rejection [6][7][8][9]. More recently, a large study employing 380 living donor LTs and 213 deceased donor LTs further showed a positive correlation between prolonged CI time and incidence of acute allograft rejection [10].…”

Targeting hypoxia signalling for the treatment of ischaemic and inflammatory diseases

“…Other studies indicate that ischaemia and reperfusion also have important immunological consequences in organ transplantation, such as affecting the severity of early liver rejection 125 or the subsequent recurrence of viral hepatitis in liver transplantation recipients that require liver transplantation for hepatitis C 126 . Therefore, hepatic ischaemia and reperfusion are an area of intense investigation, and novel therapeutic strategies that dampen liver injury following ischaemia and reperfusion are urgently needed.…”

Cytoprotective Effects of Human Interleukin-10 Gene Transfer Against Necrosis and Apoptosis Induced by Hepatic Cold Ischemia/Reperfusion Injury

“…However, organ shortage significantly reduces the applicability of this procedure. I/R injury, an Ag-independent component of the harvesting insult, affects the outcome after transplantation and plays an important role in post-transplant complications, including primary nonfunction (PNF) and acute and chronic rejection [1,2]. Additionally, because of the higher susceptibility of marginal livers to ischemia insult, I/R injury contributes to the shortage of livers available for transplantation [3].…”