Influence of iron on plutonium absorption by the adult and neonatal rat*1

Sullivan, M.F.; Ruemmler, P.S.; Buschbom, R.L.

doi:10.1016/0041-008x(86)90118-3

Cited by 3 publications

(4 citation statements)

References 25 publications

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“…Ragan demonstrated (Ragan 1977) that iron-deficient mice absorbed four times as much Pu as iron-replete mice. We obtained (Sullivan et al 1986b, Sullivan et al 1986a) similar results with iron-deficient rats, and also found that neonates suckled by dams that were iron-deficient absorbed twice as much Pu as those suckled by dams fed an iron-replete diet. Most of the transfer factors (fl values) available to the International Commission on Radiological Protection (ICRP 1972(ICRP , 1979 for recommending annual limits of intake (ALI) of ingested actinides by man were derived from studies in other mammalian species fed an ironreplete diet.…”

Section: Introductionsupporting

confidence: 87%

“…Evidence lies in the increased absorption of the actinide by iron-deficient groups, compared to iron-replete groups, and the effect of dietary iron (Sullivan et al 1986b and Table 1) or iron solutions (Table 2) in blocking absorption. In our experiments, iron deficiency increased absorption of 237Np 7-fold; for 238Pu (Sullivan et al 1986a, Ragan 1975) the increase was 4-fold; for 233U, 3-fold; for 24'Am, 2.7-fold; and for 244Cm, 1.7-fold. The trivalent actinides A m and Cm are not as readily hydrolyzed as Pu at the pH of the intestine, so they are absorbed better than Pu (ICRP 1979).…”

Section: Percent Of Gavaged 23epu Dose F Sem X 100mentioning

confidence: 79%

“…Recently, we showed (Sullivan et al 1986a) that both retention and urinary excretion of 238Pu was elevated in rats fed an iron-deficient diet, and offspring of those dams retained twice as much 238Pu as those suckled by dams on an iron-replete diet. Comparing VPRC of rats given an iron-deficient diet and gavaged with 237Np and 244Cm with those gavaged with 233U and 241Am shows that feeding the dams an iron-deficient diet before weaning was more effective in reducing intake of iron.…”

Section: Discussionmentioning

confidence: 96%

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Absorption of 233U, 237Np, 238Pu, 241Am and 244Cm From the Gastrointestinal Tracts of Rats Fed an Iron-Deficient Diet

Sullivan¹,

Ruemmler²

1988

Health Physics

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Absorption of U, Np, Am and Cm was increased by factors of 3.4, 7.1, 2.7 and 1.7, respectively, when nitrate solutions of these actinides were gavaged to adult rats fed an iron-deficient diet. Retention increased proportionately in liver, kidney and carcass. The concentration of the actinides excreted also increased substantially (over that of controls) in the urine of iron-deficient rats gavaged with 233U and 237Np, but not in those with 241Am or 244Cm. Weanling rats on an iron-deficient diet, gavaged with ferric nitrate immediately before administration of 238Pu nitrate, retained between 4% and 12% of the 238Pu retained by litter mates that were not treated intragastrically with iron.

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Section: Introductionsupporting

confidence: 87%

Section: Percent Of Gavaged 23epu Dose F Sem X 100mentioning

confidence: 79%

Section: Discussionmentioning

confidence: 96%

See 1 more Smart Citation

Absorption of 233U, 237Np, 238Pu, 241Am and 244Cm From the Gastrointestinal Tracts of Rats Fed an Iron-Deficient Diet

Sullivan¹,

Ruemmler²

1988

Health Physics

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“…It must be noted that in workers exposed to plutonium, high iron stores might serve to reduce the risk of plutonium absorption. Plutonium binds to ferritin and transferrin and when iron stores are high, plutonium absorption is lowest (119,120).…”

Section: Iron As Limiting Nutrientmentioning

confidence: 99%

Iron, radiation, and cancer.

Stevens

Kalkwarf

1990

Environ Health Perspect

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Increased iron content of cells and tissue may increase the risk of cancer. In particular, high available iron status may increase the risk of a radiation-induced cancer. There are two possible mechanisms for this effect: iron can catalyze the production of oxygen radicals, and it may be a limiting nutrient to the growth and development of a transformed cell in vivo. Given the high available iron content of the western diet and the fact that the world is changing to the western model, it is important to determine if high iron increases the risk of cancer.

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Effect of excess Fe on cd or Pb absorption by rats

Sullivan

Ruemmler

1987

Journal of Toxicology and Environmental Health

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Absorption of cadmium and lead from the gastrointestinal (GI) tract of adult rats was measured after gavage with solutions of 109Cd or 210Pb. Before the radionuclide gavage, animals were either fed or fasted for 24 h, or fasted and given a supplemental gavage of ferric or ferrous iron. Fasting caused a slight increase in 109Cd absorption that was not statistically significant; ferrous iron caused a three-fold increase; and ferric iron increased absorption 14-fold. In contrast, fasting increased 210Pb absorption fivefold, and the oxidizing agents ferric iron and quinhydrone blocked the effect of fasting. Gavage of 8-d-old rats with 109Cd and either ferric or ferrous iron doubled the amount of cadmium retained in the carcass and substantially decreased the amount retained in the GI tract. Some of the large fraction (60-70%) of 109Cd stored in the mucosa of the intestine was absorbed into the body with time. An excess of ferric iron had an opposite effect on the retention of lead in the carcasses of 8-d-old rats, decreasing it from 53% of the gavaged dose to 3%; the effect on the amount retained in the intestine was similar, decreasing it from 16% to 8%. These results suggest that the mechanisms for transport of cadmium and iron across the intestine may be similar in the adult and neonatal rat, but that the oxidizing effect of ferric iron on cadmium absorption is much greater in the adult.

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Influence of iron on plutonium absorption by the adult and neonatal rat*1

Cited by 3 publications

References 25 publications

Absorption of 233U, 237Np, 238Pu, 241Am and 244Cm From the Gastrointestinal Tracts of Rats Fed an Iron-Deficient Diet

Absorption of 233U, 237Np, 238Pu, 241Am and 244Cm From the Gastrointestinal Tracts of Rats Fed an Iron-Deficient Diet

Iron, radiation, and cancer.

Effect of excess Fe on cd or Pb absorption by rats

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