Influence of iron doping towards the physicochemical and biological characteristics of hydroxyapatite

Balakrishnan, Subha; Padmanabhan, Varun Prasath; Ravichandran, K.; Nellaiappan, T.S. Sankara Narayanan; Sagadevan, Suresh; Paiman, Suriati; Mohammad, Faruq; Al‐Lohedan, Hamad A.; Obulapuram, Prasanna Kumar; Oh, Won Chun

doi:10.1016/j.ceramint.2020.10.084

Cited by 41 publications

(16 citation statements)

References 29 publications

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“…Granules of Fe-HA7 have indicated strongly marked matrix characteristics. Similar behavior of Fe-dopped HA was previously observed by S. Balakrishnan et al [ 30 ] and was linked with a decrease in intracellular reactions due to the fall of free Ca 2+ ions. Moreover, the biocompatibility of composite powders based on HA and Fe 3 O 4 nanoparticles was observed in vivo on the New Zealand white rabbits dorsocranial incisions model [ 72 ].…”

Section: Resultssupporting

confidence: 88%

“…The STEM data confirmed the tendency to form needle-like and rod-shaped particles with lengths up to 50 nm compared with hexagonal ones for pure HA ( Figure 4 ). Previously, in [ 30 ] the increase in Fe 3+ amount resulted in the formation of the spherical structures compared to rod-like for pure HA. Fe-HA synthesized from Ca(OH) 2 and FeCl 3 as sources of the cations resulted in the formation of acicular particles of irregular contour with a size of 50–100 nm [ 54 ].…”

Section: Resultsmentioning

confidence: 96%

“…Fe 3+ ions and Fe oxides play an important role in the biomedical and technical applications of the HA. The synthesis of Fe-dopped HA is typically performed by using Fe(NO 3 ) 3 [ 30 ] or FeCl 3 [ 45 ]. At the same time, iron (III) oxalate has good solubility in water and has been demonstrated as a promising precursor to obtain nanosized particles of iron oxides [ 73 ].…”

Section: Discussionmentioning

confidence: 99%

“…Fe-HA powders are promising for cancer monitoring [ 27 ], as well as magnetic resonance imaging [ 28 ], drug delivery, and heat mediation for the hyperthermia treatment of cancers [ 29 ]. Although the influence of Fe 3+ content on the physicochemical properties including crystalline size was discussed previously [ 30 ], there is no data on the formation of porosity and dependence of Fe 3+ amount on the S of the powders. The introduction of Fe 3 O 4 nanoparticles increased the S [ 31 ] up to 124 m 2 /g compared to 116 m 2 /g demonstrated for pure HA and also up to 148 m 2 /g HA-coated Fe 3 O 4 compared to 141 m 2 /g for pure HA [ 32 ], these developed materials demonstrated controlled drug release of the doxorubicin.…”

Section: Introductionmentioning

confidence: 99%

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Mesoporous Iron(III)-Doped Hydroxyapatite Nanopowders Obtained via Iron Oxalate

et al. 2021

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Mesoporous hydroxyapatite (HA) and iron(III)-doped HA (Fe-HA) are attractive materials for biomedical, catalytic, and environmental applications. In the present study, the nanopowders of HA and Fe-HA with a specific surface area up to 194.5 m2/g were synthesized by a simple precipitation route using iron oxalate as a source of Fe3+ cations. The influence of Fe3+ amount on the phase composition, powders morphology, Brunauer–Emmett–Teller (BET) specific surface area (S), and pore size distribution were investigated, as well as electron paramagnetic resonance and Mössbauer spectroscopy analysis were performed. According to obtained data, the Fe3+ ions were incorporated in the HA lattice, and also amorphous Fe oxides were formed contributed to the gradual increase in the S and pore volume of the powders. The Density Functional Theory calculations supported these findings and revealed Fe3+ inclusion in the crystalline region with the hybridization among Fe-3d and O-2p orbitals and a partly covalent bond formation, whilst the inclusion of Fe oxides assumed crystallinity damage and rather occurred in amorphous regions of HA nanomaterial. In vitro tests based on the MG-63 cell line demonstrated that the introduction of Fe3+ does not cause cytotoxicity and led to the enhanced cytocompatibility of HA.

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Section: Resultssupporting

confidence: 88%

Section: Resultsmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Mesoporous Iron(III)-Doped Hydroxyapatite Nanopowders Obtained via Iron Oxalate

et al. 2021

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“…Consequently, the pseudo-piezoelectric behavior can be tuned in a way that the bone cells can sense stimulations to improve the healing process. Utilizing doping elements which are already present in human body, i.e., Mg and Fe, should not cause any harm [ 13 , 14 ]. In the present study, pure CaTiO 3 and doping with Mg and Fe were prepared and the effect of doping on the crystal structure and pseudo-piezoelectric behavior of CaTiO 3 was investigated.…”

Section: Introductionmentioning

confidence: 99%

Tunable Pseudo-Piezoelectric Effect in Doped Calcium Titanate for Bone Tissue Engineering

et al. 2021

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CaTiO3 is a promising candidate as a pseudo-piezoelectric scaffold material for bone implantation. In this study, pure and magnesium/iron doped CaTiO3 are synthesized by sol-gel method and spark plasma sintering. Energy dispersive X-ray mapping confirm the homogenous distribution of doping elements in sintered samples. High-energy X-ray diffraction investigations reveal that doping of nanostructured CaTiO3 increased the strain and defects in the structure of CaTiO3 compared to the pure one. This led to a stronger pseudo-piezoelectric effect in the doped samples. The charge produced in magnesium doped CaTiO3 due to the direct piezoelectric effect is (2.9 ± 0.1) pC which was larger than the one produced in pure CaTiO3 (2.1 ± 0.3) pC, whereas the maximum charge was generated by iron doped CaTiO3 with (3.6 ± 0.2) pC. Therefore, the pseudo-piezoelectric behavior can be tuned by doping. This tuning of pseudo-piezoelectric response provides the possibility to systematically study the bone response using different piezoelectric strengths and possibly adjust for bone tissue engineering.

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Bioactive Magnetic Materials in Bone Tissue Engineering: A Review of Recent Findings in CaP‐Based Particles and 3D‐Printed Scaffolds

Carvalho

Torres

Belo

et al. 2023

Advanced NanoBiomed Research

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Diverse applications of nanoparticles (NP) have been revolutionary for various industrial sectors worldwide. In particular, magnetic nanoparticles (MNP) have gained great interest because of their applications in specialized medical areas. This review starts with a brief overview of the magnetic behavior of MNP and a short description of their most used synthesis methods. The second part is dedicated to the MNP applications in tissue engineering, emphasizing the calcium phosphate‐based NP with intrinsic magnetic properties, recently highlighted in the literature as alternative and viable solutions for bone regeneration. The challenges associated with the controversial long‐term toxicity effects of MNP can be overcome using this new generation of multifunctional bone‐like magnetic materials. Furthermore, the influence of magnetic field parameters, such as modality of application, intensity, and spatial distribution, on the biological behavior of magnetic materials, especially for bone repair, is shown. The last part of the review presents the current state of the art regarding the development of magnetic biomaterials for additive manufacturing (AM), aiming to fabricate scaffolds by AM technologies, focusing on bone tissue engineering applications.

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Influence of iron doping towards the physicochemical and biological characteristics of hydroxyapatite

Cited by 41 publications

References 29 publications

Mesoporous Iron(III)-Doped Hydroxyapatite Nanopowders Obtained via Iron Oxalate

Mesoporous Iron(III)-Doped Hydroxyapatite Nanopowders Obtained via Iron Oxalate

Tunable Pseudo-Piezoelectric Effect in Doped Calcium Titanate for Bone Tissue Engineering

Bioactive Magnetic Materials in Bone Tissue Engineering: A Review of Recent Findings in CaP‐Based Particles and 3D‐Printed Scaffolds

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