Influence of Iron Administration on Kidney Serum Parameters

Abstract

Some minerals are essential nutrients for organisms being necessary in different quantities, but any homeostasis disturbance (deficiency or excess) can lead to various diseases. Iron in the body plays a critical role being directly involved in the respiration process - more precisely O2 and CO2 transportation, and also in beneficial oxidation-reduction processes. But sometimes the iron can also lead to the formation of substances with toxicogenic potential, more precisely to free radicals formed as a result of oxidative stress. In the liver, there is a specialized protein - hepcidin - which is the key regulator of circulating iron in the organism. In several cases of overdose, this protein blocks the iron transportation, binds it to the export channels of ferroportin and finally sends the excess iron to the kidney for urinal excretion. Our experiment tried to evaluate if in case of iron intraperitoneal administration in excess to rabbits, for a short period of time, it influences the serum creatinine, uric acid, and blood urea nitrogen if the rabbits were fed with a special organic diet. The results of the experiment presented a lower concentration of creatinine (with 24.46%), uric acid (with more than 41.48%), and blood urea nitrogen - BUN (6.45%) for experimental rabbits compared to the control group, proving that a well-documented diet influences the accumulation and excretion of excess iron. Keywords: iron, creatinine, uric acid, blood urea nitrogen