Influence of Intraoperative Radiotherapy (IORT) on Perioperative Outcome after Surgical Resection of Rectal Cancer

Klink, Christian D.; Binnebösel, Marcel; Holý, Richard; Neumann, Ulf; Junge, K.

doi:10.1007/s00268-013-2313-1

Cited by 12 publications

(6 citation statements)

References 29 publications

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“…Klink et al evaluated retrospectively 162 patients with LARC of whom 52 received IORT and the remainder were treated with resection alone. The authors did not find any difference in the perioperative complication rates between the 2 groups (85). Prospective randomized trials are needed to properly evaluate the benefit and toxicity of IORT in patients with locally advanced or recurrent rectal cancer.…”

Section: Intraoperative Radiation Therapy (Iort)mentioning

confidence: 85%

The Impact of Novel Radiation Treatment Techniques on Toxicity and Clinical Outcomes in Rectal Cancer

Hathout

Williams

Jabbour

2017

Curr Colorectal Cancer Rep

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Purpose of review Three-dimensional conformal radiation therapy (3DCRT) has been the standard technique in the treatment of rectal cancer. The use of new radiation treatment technologies such as intensity-modulated radiation therapy (IMRT), proton therapy (PT), stereotactic body radiation therapy (SBRT) and brachytherapy (BT) has been increasing over the past 10 years. This review will highlight the advantages and drawbacks of these techniques. Recent findings IMRT, PT, SBRT and BT achieve a higher target coverage conformity, a higher organ at risk sparing and enable dose escalation compared to 3DCRT. Some studies suggested a reduction in gastrointestinal and hematologic toxicities and an increase in the complete pathologic response rate; however, the clinical benefit of these techniques remains controversial. Summary The results of these new techniques seem encouraging despite conclusive data. Further trials are required to establish their role in rectal cancer.

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Section: Intraoperative Radiation Therapy (Iort)mentioning

confidence: 85%

The Impact of Novel Radiation Treatment Techniques on Toxicity and Clinical Outcomes in Rectal Cancer

Hathout

Williams

Jabbour

2017

Curr Colorectal Cancer Rep

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“…Reports with reirradiation with or without hyperthermia or IORT (Intraoperative Radiotherapy) and surgery reported up to 40% 5‐year survival with 5–15% >grade III toxicity and excellent palliation . There have been many reports of use of IORT as an adjunct to surgery in this situation with reasonable local control rates . In a more recent series the rate of local failure was reportedly higher at 53%.…”

Section: Discussionmentioning

confidence: 99%

Stereotactic body radiotherapy (SBRT) reirradiation for pelvic recurrence from colorectal cancer

Dağoğlu

Mahadevan

Nedea

et al. 2015

Journal of Surgical Oncology

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“…[17] Hipertermi veya (intraoperatif RT) IORT ile birlikte yapılabilen tekrar radyoterapisi ve cerrahi birlikteliğinde beş yıllık sağkalım %40, grade III toksisite %5-15'ten az olarak bildirilmiştir [31][32][33] Cerrahiyle birlikte IORT kullanımında makul lokal kontrol oranlarının bildirildiği birçok çalışma mevcuttur. [34][35][36][37][38] Ancak daha yakın bir zamanda yayınlanan bir olgu çalışmasında lokal başarısızlık oranı %53 gibi yüksek bir oranda bildirilmiştir. [36] Bununla birlikte IORT kötü yara iyileşmesi, anastomoz kaçakları ve kanama gibi sonuçları ve komplikasyonları beraberinde getiren radikal bir cerrahiyi içermektedir.…”

Section: Discussionunclassified

Is stereotactic body radiotherapy a treatment option for pelvic recurrences?

Dağoğlu¹

2015

TJ Oncol

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KliNiK ÇalIŞma ORIGINAL ARTICLE oBJeCtIVeSWhen surgery is not adequate, stereotactic body radiotherapy (SBRT) has been used for recurrent cancers. We report the outcomes of case series with pelvic recurrences from colorectal cancer irradiated with SBRT. metHoDSRobotic Stereotactic Radiotherapy system was used. The dose fractionation scheme was individualized based on tumor volume and location and prior radiation dose. reSultSBetween February 2010 and December 2014, four patients were treated. Treatment regions were pelvic side wall for two patients and presacral for two patients. SBRT doses were 24 Gy in 3 fractions for three patients and 36.25 Gy in 5 fractions for one patient.One patient treated for pelvic side wall recurrence developed symptomatic noropathy at fist year. CoNCluSIoNLocal recurrence in pelvis after modern combined modality treatment for colorectal cancer is rare. However it presents a therapeutic dilemma when it occurs; often symptomatic and eventually life threatening. SBRT can be a useful modality in this setting.

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Influence of Intraoperative Radiotherapy (IORT) on Perioperative Outcome after Surgical Resection of Rectal Cancer

Abstract: Intraoperative radiotherapy appears to be a safe treatment option in patients with locally advanced or recurrent rectal cancer with acceptable complication rates. The effect on local recurrence rate has to be estimated in long-term follow-up.

Cited by 12 publications

References 29 publications

The Impact of Novel Radiation Treatment Techniques on Toxicity and Clinical Outcomes in Rectal Cancer

The Impact of Novel Radiation Treatment Techniques on Toxicity and Clinical Outcomes in Rectal Cancer

Stereotactic body radiotherapy (SBRT) reirradiation for pelvic recurrence from colorectal cancer

Is stereotactic body radiotherapy a treatment option for pelvic recurrences?

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