Influence of Intestinal Microbiota on Body Weight Gain: a Narrative Review of the Literature

Cardinelli, Camila de Siqueira; Sala, Priscila; Alves, Cléber R.; Torrinhas, Raquel Susana; Waitzberg, Dan Linetzky

doi:10.1007/s11695-014-1525-2

Cited by 55 publications

(42 citation statements)

References 82 publications

(134 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Gut microbes have been linked to chronic inflammation and altered fat storage in obese people [29], [30], [31], [32]. In addition, the transfer of gut microbes from obese mice can transmit the obesity phenotype to lean mice [33].…”

Section: Discussionmentioning

confidence: 99%

Nickel-resistant bacteria isolated in human microbiome

Lusi¹,

Patrissi²,

Guarascio

2017

New Microbes and New Infections

View full text Add to dashboard Cite

Nickel-resistant bacteria have been isolated so far only in contaminated soils and wastewaters polluted with different industrial sources. The aim of our study was to determine if nickel-resistant bacteria could also be isolated from human samples. In this brief communication, we describe how we were able to isolate human bacterial strains that grew without oxygen and in the presence of high concentrations of nickel. The identification was made by phenotypic and genetic techniques. The bacterial sequences have been deposited in the NCBI database repository. Our finding shows that there are several different heavy-metal-tolerant bacteria in humans that should be considered for further studies.

show abstract

Section: Discussionmentioning

confidence: 99%

Nickel-resistant bacteria isolated in human microbiome

Lusi¹,

Patrissi²,

Guarascio

2017

New Microbes and New Infections

View full text Add to dashboard Cite

show abstract

“…When they transferred the gut microbiota from obese and lean mice to germ-free mice, germ-free mice that received microbiota from obese mice, compared with those that received the gut microbiota from lean mice had higher energy extraction from food and showed greater weight gain. It was also reported that people with obesity have a less diverse gut microbiota than those with normal body weight (24). These findings suggest that gut microbiota is probably not a mere consequence of obesity and may have a prominent role in overweight and obesity pathogenesis.…”

Section: Discussionmentioning

confidence: 99%

“…The alteration of endotoxin can be involved in changes in energy extraction from the diet and modulation of endocrine functions, lipid metabolism, and the immune system. It can contribute to obesity or metabolic syndrome (34). Metabolic endotoxemia (ME, increased endotoxin in blood) also triggers toll-like receptor 4-mediated inflammatory adipokines and leads to a chronic low grade inflammatory status, which affects cardiovascular risk increase and target organ damage (1567).…”

Section: Introductionmentioning

confidence: 99%

The Curves Exercise Suppresses Endotoxemia in Korean Women with Obesity

et al. 2017

View full text Add to dashboard Cite

Obesity and metabolic syndrome is a worldwide pandemic and associated with high cardiovascular risk. Metabolic endotoxemia (ME) is thought to be an underlying molecular mechanism. It triggers toll-like receptor 4-mediated inflammatory adipokines and causes a chronic low grade inflammatory status, which results in cardiovascular risk increase. Exercise is the best nonpharmacological treatment to improve prognosis. In this study, we examined the circulating endotoxin level in Korean obese women and investigated effects of exercise on it. Women over body mass index (BMI) 25 kg/m2 participated in a resistance training exercise, Curves. At baseline and after 12 weeks exercise, tests including blood samples were taken. In Korean obese women, the fasting endotoxin was 1.45 ± 0.11 EU/mL. Ingestion of a high calorie meal led to a peak level after 2 hours (postprandial 2 hours [PP2]) and a significant rise over the 4 hours (postprandial 4 hours [PP4]) in it (1.78 ± 0.15 and 1.75 ± 0.14 EU/mL for PP2 and PP4, P < 0.05 vs. fasting). After exercise, BMI and hip circumference were reduced significantly. The total cholesterol (TC) at fasting, PP2 and PP4 were decreased significantly. All levels of circulating endotoxin at fasting, PP2 and PP4 showed reduction. But, the peak change was only significant (baseline vs. 12 weeks for PP2; 1.78 ± 0.15 vs. 1.48 ± 0.06 EU/mL, P < 0.05). We report the circulating endotoxin level in Korean obese women for the first time. Also, we establish that energy intake leads to endotoxemia and exercise suppresses the peak endotoxemia after meal. It suggests an impact for a better prognosis in obese women who follow regular exercise.

show abstract

“…High-throughput genome sequencing of microbial communities in the mammalian gastrointestinal system continues to present diverse protein function information to understand the microbial molecular mechanisms that influence obesity development [5,6]. The Gram-positive bacteria genus Lactobacillus includes probiotic members which have been investigated for the metabolic role in weight modification in humans [7,8].…”

Section: Introductionmentioning

confidence: 99%

“…Lactobacilli that inhabit the human gastrointestinal system or part of probiotics must respond to unfavorable conditions including stomach acid, bile acid and low oxygen. This research article contributes knowledge on environmental factors (gastrointestinal microbiota) that could influence the development of obesity [5,6], a major risk factor for diseases such as diabetes, cancer, and cardiovascular disease [9,10,11]. Proteins that contain the universal stress protein domain (Protein Family (Pfam)Accession: PF00582 or pfam00582) are known to confer diverse categories of organisms including bacteria with the ability to respond to habitat-related stress conditions.…”

Section: Introductionmentioning

confidence: 99%

Genomic Evidence for Bacterial Determinants Influencing Obesity Development

Isokpehi

Simmons

Johnson

et al. 2017

IJERPH

View full text Add to dashboard Cite

Obesity is a major global public health problem requiring multifaceted interventional approaches including dietary interventions with probiotic bacteria. High-throughput genome sequencing of microbial communities in the mammalian gastrointestinal system continues to present diverse protein function information to understand the bacterial determinants that influence obesity development. The goal of the research reported in this article was to identify biological processes in probiotic bacteria that could influence the mechanisms for the extraction of energy from diet in the human gastrointestinal system. Our research strategy of combining bioinformatics and visual analytics methods was based on the identification of operon gene arrangements in genomes of Lactobacillus species and Akkermansia muciniphila that include at least a gene for a universal stress protein. The two major findings from this research study are related to Lactobacillus plantarum and Akkermansia muciniphila bacteria species which are associated with weight-loss. The first finding is that Lactobacillus plantarum strains have a two-gene operon that encodes a universal stress protein for stress response and the membrane translocator protein (TSPO), known to function in mitochondrial fatty acid oxidation in humans. The second finding is the presence of a three-gene operon in Akkermansia muciniphila that includes a gene whose human mitochondrial homolog is associated with waist-hip ratio and fat distribution. From a public health perspective, elucidation of the bacterial determinants influencing obesity will help in educating the public on optimal probiotic use for anti-obesity effects.

show abstract

Influence of Intestinal Microbiota on Body Weight Gain: a Narrative Review of the Literature

Cited by 55 publications

References 82 publications

Nickel-resistant bacteria isolated in human microbiome

Nickel-resistant bacteria isolated in human microbiome

The Curves Exercise Suppresses Endotoxemia in Korean Women with Obesity

Genomic Evidence for Bacterial Determinants Influencing Obesity Development

Contact Info

Product

Resources

About