Influence of Intestinal Indigenous Microbiota on Intrafamilial Infection by Helicobacter pylori in Japan

Osaki, Takako; Zaman, Cynthia; Yonezawa, Hideo; Lin, Yingsong; Okuda, Masumi; Nozaki, Eriko; Hojo, Fuhito; Kurata, Satoru; Hanawa, Tomoko; Kikuchi, Shogo; Kamiya, Shigeru

doi:10.3389/fimmu.2018.00287

Cited by 17 publications

(17 citation statements)

References 33 publications

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“…Osaki et al 30 conducted a study in Japan by analyzing whether gut microbiota may affect intrafamilial H pylori transmission. The composition of gut microbiota among members of the same family was found to be very similar; however, no difference in gut microbiota was noted between H pylori-positive and -negative subjects.…”

Section: Is There a Role For Other Gut Microbiota In H Pylori Transmentioning

confidence: 99%

Review: Epidemiology of Helicobacter pylori infection

et al. 2019

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This review summarizes recent publications on the epidemiology of Helicobacter pylori. Two major systemic analyses, from Malaysia and Ethiopia, were published. The Brazilian Consensus Conference has stated that H pylori infection is an infectious disease with an indication for antimicrobial therapy. A continuous decrease in H pylori prevalence was reported from many regions worldwide, including Korea, China, Iran, and Austria. A cross‐sectional H pylori prevalence study conducted in the United Arab Emirates found 41% prevalence in a group of healthy children and adults. Several studies from Asia addressed H pylori prevalence in adults undergoing regular checkup. The largest of such studies, performed in Korea, involved 24 471 subjects and reported 41.5% seroprevalence. A relatively smaller study from East China on 3252 subjects reported 27.5% prevalence. In contrast, a study from Spain reported 87.2% seroprevalence. A report on the association between smoking and H pylori seropositivity was published on behalf of the Stomach Cancer Pooling (StoP) Project—a consortium of epidemiological studies of gastric cancer. Also, other potential risk factors, including occupational risk factors, water supply, and food were analyzed. Gastroesophageal reflux and sexual partners has been associated with a higher risk for H pylori acquisition, and gut microbiota was suggested to play a role in intrafamilial transmission of H pylori. Finally, in a few studies (from Mexico and Japan), the catalytic model for predicting the potential risk of acquiring H pylori infection in the future was used. As anticipated, a further decline in H pylori‐related disease was demonstrated by applying the modeling.

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Section: Is There a Role For Other Gut Microbiota In H Pylori Transmentioning

confidence: 99%

Review: Epidemiology of Helicobacter pylori infection

et al. 2019

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“…Family microbiota is shared between parents and children and may play an important role in the composition of infant microbiota. Whether intestinal microbiota can affect H. pylori intrafamilial infection has been investigated (Osaki et al 2018). The microbiota composition of 18 fecal specimens from five H. pylori-infected children and their family members were analysed in five families.…”

Section: 1a-2 Microbiotamentioning

confidence: 99%

Epidemiology, Diagnosis and Risk Factors of Helicobacter pylori Infection

Kotilea

Bontems

Touati

2019

Advances in Experimental Medicine and Biology

110

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Helicobacter pylori is a human-specific pathogen which leads to gastric pathologies including gastric cancer. It is a highly unique bacterium considered as a carcinogenic agent. H. pylori remains a major human health problem, responsible for ~90% of the gastric cancer cases. Approximately four billion individuals have been detected for H. pylori infection worldwide in 2015. At the turn of the 21 st century, the prevalence of H. pylori has been declining in highly industrialized countries of the Western world, whereas prevalence has plateaued at a high level in developing and newly industrialized countries. However, the infection status remains high in immigrants coming from countries with high prevalence of H. pylori infection. H. pylori can be diagnosed by invasive and non-invasive methods. Urea breath test and stool antigens detection are among the most commonly used non-invasive ones. Although the way H. pylori is transmitted remains still unclear, the level of contamination is strongly dependent on the familial and environmental context, with a drastic impact of living conditions with poor hygiene and sanitation. However, familial socioeconomic status is the main risk factor for H. pylori infection among children. In addition, food and water source have a high impact on the prevalence of H. pylori infection worldwide. This chapter highlights the latest knowledge in the epidemiology of H. pylori infection, its diagnosis and critical risk factors responsible for its high prevalence in some populations and geographic areas.

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“…Additionally, a Japanese study of 1,123 adult subjects, using 16S rRNA amplification from fecal samples, also confirmed higher abundance of Lactobacillus in H. pylori -infected subjects with severe atrophic gastritis (Iino et al, 2018). However, there has been only one study related to fecal microbiota and H. pylori infection in children, which included 18 fecal samples from five Japanese families (Osaki et al, 2018). These indicated a similar composition of intestinal microbiota between members of the same family, but the sample size was small.…”

Section: Introductionmentioning

confidence: 99%

Helicobacter pylori Infection Aggravates Dysbiosis of Gut Microbiome in Children With Gastritis

Yang

Zhang

et al. 2019

Front. Cell. Infect. Microbiol.

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Introduction: Helicobacter pylori infection consistently leads to chronic and low degree of inflammatory response in gastric mucosa and is closely related with gastrointestinal and extra-gastric diseases. Effects of local microbiome in the stomach have been studied in adults and children with H. pylori infection. It is, however, not known whether the intestinal microbial community differs in children with varying H. pylori infection. The aim of this study is to characterize the altered composition of microbiome induced by H. pylori infection and in gastritis.Materials and Methods: This study involved 154 individuals, including 50 children affected by H. pylori-induced gastritis, 42 children with H. pylori-negative gastritis, and 62 healthy controls. Gut microbiome composition was analyzed using 16S rRNA gene-based pyrosequencing. Fecal bacterial diversity and composition were then compared.Results: On the basis of an analysis of similarities and differences, we found that children with H. pylori-induced gastritis exhibited gut bacteria dysbiosis. The ratio of Firmicutes/Bacteroidetes (F:B) at the phylum level had dramatically decreased in H. pylori-positive gastritis group (HPG) and H. pylori-negative gastritis group (HNG), compared with the healthy control group (HCG). At the family and genus levels, relative abundance of Bacteroidaceae and Enterobacteriaceae was prevalent in HPG and HNG, whereas relative abundance of Lachnospiraceae, Bifidobacteriaceae, and Lactobacillaceae was seen in HCG. Prevalence of different taxa of gut microbiome at the class, order, family, and genus levels was also observed among the three groups.Conclusions: Gastritis can cause changes in composition of fecal microbiome, which is exacerbated by H. pylori infection. These changes in gut microbiome may be related to drug resistance and development of chronic gastrointestinal diseases.

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Influence of Intestinal Indigenous Microbiota on Intrafamilial Infection by Helicobacter pylori in Japan

Cited by 17 publications

References 33 publications

Review: Epidemiology of Helicobacter pylori infection

Review: Epidemiology of Helicobacter pylori infection

Epidemiology, Diagnosis and Risk Factors of Helicobacter pylori Infection

Helicobacter pylori Infection Aggravates Dysbiosis of Gut Microbiome in Children With Gastritis

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