Influence of Intermittent Hypoxia on Intravenous Glucose Tolerance and Insulin Sensitivity in Anaesthetized Normal Rats

Djovkar, Assadollah

doi:10.1055/s-2007-1018685

Cited by 9 publications

(4 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Animal studies also have shown that insulin resistance may be induced or exacerbated by overnight sympathoexcitation and/or hypoxemia. 9 Several clinic-based studies have demonstrated a relationship between SDB and insulin resistance. 15,22,[44][45][46][47][48] In one case-control study, HOMA-IR was significantly higher in a sleep apnea sample than a BMI-matched control group.…”

Section: Discussionmentioning

confidence: 99%

A Controlled Trial of CPAP Therapy on Metabolic Control in Individuals with Impaired Glucose Tolerance and Sleep Apnea

Weinstock

Wang

Rueschman

et al. 2012

Sleep

163

119

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

A Controlled Trial of CPAP Therapy on Metabolic Control in Individuals with Impaired Glucose Tolerance and Sleep Apnea

Weinstock

Wang

Rueschman

et al. 2012

Sleep

163

119

View full text Add to dashboard Cite

show abstract

“…Among the diabetic patients described here, two presented initially with nonarteritic anterior ischemic optic neuropathy. Djovkar et al [34] also showed influence of intermittent hypoxia on intravenous glucose tolerance and insulin sensitivity in anaesthetized normal rats.…”

Section: Discussionmentioning

confidence: 99%

A Putative Relation between Obstructive Sleep Apnea and Diabetic Macular Edema Associated with Optic Nerve Fiber Layer Infarcts

Ünver¹,

Yavuz²,

Stafford³

et al. 2009

TOSLPJ

View full text Add to dashboard Cite

Abstract:Purpose: To describe a possible relationship in obese diabetics between obstructive sleep apnea syndrome (OSAS) and ischemic retinopathy with diffuse macular edema.Design: Prospective, observational case series. Methods:Obese diabetics (n=22) in a retina clinic who admitted to symptoms of sleep apnea on survey were compared with a cohort of 22 similarly obese diabetic patients.Complete ocular examination, fundus photography, fluorescein angiography,overnight polysomnography, blood pressure measurement, and blood testing for HgA1C, CBC, lipid profile, ESR, c reactive protein, BUN, creatinine and proteinuria were evaluated.Results: Among the 22 obese diabetics of apnea cohort who underwent polysomnography, 16 demonstrated severe and 6 moderate OSAS. An average of 44.6+21.9 apneic or hypopneic events per hour were recorded during sleep, lasting on average 23.3+5.9 seconds, resulting in oxygen desaturation of 73.5+9.5%. The retinopathy observed in the apnea cohort manifested multiple nerve-fiber-layer infarcts, at least 3 in each eye in all cases, and more than 6 infarcts in most eyes.. Among the cohort without sleep apnea, rare nerve fiber layer infarcts were observed, and the retinal microvascular leakage and macular edema was more focal and resolved with grid laser. Among the measured systemic factors, none showed a statistical difference between apneic and non-apneic cohorts. Conclusions:In obese diabetics, obstructive sleep apnea appears to be associated with retinopathy of more aggressive course, manifesting multiple nerve-fiber-layer infarction and diffuse macular edema. Physicians should consider evaluating obese diabetics who have snoring, fragmented sleep patterns, daytime somnolence, hypertension or manifesting accelerated course of retinopathy similar to the patients described.

show abstract

“…Experimental protocols expose rodents to intermittent hypoxia (IH 1 ) to simulate the blood gas changes that occur in sleep apnea; while they vary in cycle length, severity of hypoxia, number of hypoxic episodes per hour, and number of exposure days, they are quite consistent in reporting mild hypertension (Fletcher 2001; Kanagy et al 2001; Lesske et al 1997), augmented vascular contractility (Allahdadi et al 2005; Julien et al 2003; Tahawi et al 2001), and metabolic alterations (Djovkar 1983; Holm et al 1973; McNulty et al 1996; Polotsky et al 2003). Thus, despite slightly different results in the time to onset of cardiovascular changes and the degree of resulting pathology, the similarities are more striking than the differences.…”

Section: Rodent Models Of Intermittent Hypoxiamentioning

confidence: 99%

Vascular Effects of Intermittent Hypoxia

Kanagy

2009

ILAR Journal

View full text Add to dashboard Cite

Obstructive sleep apnea is characterized by repeated upper airway obstruction during sleep and affects between 5% and 20% of the population. Epidemiological studies reveal that sleep apnea and associated intermittent hypoxemia increase the risk for hypertension and vascular disease but the mechanisms underlying these effects are incompletely understood. This review reports the results of rodent models of intermittent hypoxia (IH) and relates them to the observed hemodynamic and vascular consequences of sleep apnea. These animal studies have demonstrated that IH exposure in the absence of any other comorbidity causes hypertension, endothelial dysfunction, and augmented constrictor sensitivity, all due at least in part to increased vascular oxidative stress. Animal studies have used a variety of exposure paradigms to study intermittent hypoxia and these different exposure protocols can cause hypocapnia or hypercapnia—or maintain eucapnia—with accompanying alterations in plasma pH. It appears that these different profiles of arterial blood gases can lead to divergent results but the impact of these differences is still being investigated. Overall, the studies in rodents have clearly demonstrated that the vascular and hemodynamic impact of intermittent hypoxia provides a strong rationale for treating clinical sleep apnea to prevent the resulting cardiovascular morbidity and mortality.

show abstract

Influence of Intermittent Hypoxia on Intravenous Glucose Tolerance and Insulin Sensitivity in Anaesthetized Normal Rats

Cited by 9 publications

References 5 publications

A Controlled Trial of CPAP Therapy on Metabolic Control in Individuals with Impaired Glucose Tolerance and Sleep Apnea

A Controlled Trial of CPAP Therapy on Metabolic Control in Individuals with Impaired Glucose Tolerance and Sleep Apnea

A Putative Relation between Obstructive Sleep Apnea and Diabetic Macular Edema Associated with Optic Nerve Fiber Layer Infarcts

Vascular Effects of Intermittent Hypoxia

Contact Info

Product

Resources

About