Influence of intermittent fasting on prediabetes-induced neuropathy: Insights on a novel mechanistic pathway

Dannawi, Maya; Riachi, Mansour E.; Haddad, Antony F.; Massry, Mohamed El; Haddad, Mary; Moukarzel, Pamela; Harb, Frédéric; Ghadieh, Hilda E.; Eid, Assaad A.

doi:10.1016/j.metop.2022.100175

Cited by 4 publications

(3 citation statements)

References 62 publications

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“…These outcomes proved the impact of IF and LCD on decreasing microvascular complications. In agreement with our results, Hammer et al 37 and Dannawi et al 38 revealed a reduction in retinopathy and neuropathy by IF, and Hwang et al, 39 revealed a recovery in microvascular endothelial function by LCD only after six weeks. A low incidence of retinopathy and neuropathy is associated with the reduction of HbA1c and fasting plasma glucose values.…”

Section: Discussionsupporting

confidence: 93%

“…[34][35][36] Esses desfechos comprovam o impacto do JI e da DLC na diminuição das complicações microvasculares. Nossos dados vão ao encontro dos descritos por Hammer et al 37 e Dannawi et al, 38 que revelaram uma redução na retinopatia e neuropatia pelo JI, e Hwang et al 39 que revelaram uma recuperação na função endotelial microvascular pela DLC somente após seis semanas. Uma baixa incidência de retinopatia e neuropatia está associada com uma redução na HbA1c e glicemia de jejum.…”

Section: Artigo Originalunclassified

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Papel do Jejum Intermitente e da Dieta Restrita em Carboidratos na Prevenção de Doenças Cardiovasculares em Pacientes Pré-Diabéticos

Khalfallah¹,

Elnagar²,

Soliman³

et al. 2023

Arquivos Brasileiros De Cardiologia

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Fundamentos: Pacientes pré-diabéticos têm alto risco de doenças cardiovasculares e complicações microvasculares e macrovasculares. O Jejum Intermitente (JI) e a dieta restrita em carboidratos (dieta low-carb, DLC) são estratégias dietéticas promissoras nesse grupo. Objetivos: Analisar os benefícios da combinação do JI com DLC sobre desfechos microvasculares e macrovasculares em pacientes pré-diabéticos. Métodos: O estudo incluiu 485 pacientes pré-diabéticos sem história de doença cardiovascular. Os pacientes foram divididos em dois grupos: grupo I (n = 240) submetidos ao JI (16 horas de JI, F 3-4 dias por semana) combinado com DLC (<130 g de carboidratos por dia), e grupo II (n = 245) que consumiram alimentos à vontade (grupo controle). Os dois grupos foram acompanhados por dois anos para avaliação de complicações macrovasculares e microvasculares. Um valor p < 0,05 foi considerado estatisticamente significativo.Resultados: Houve uma redução significativa no peso corporal, índice de massa corporal, porcentagem de gordura corporal e hemoglobina glicada no grupo I. A incidência de progressão de pré-diabetes para diabetes foi significativamente menor no grupo I (2,1%) que no grupo II (6,9%) (p = 0,010). Ainda, um aumento significativo na incidência de complicações microvasculares e macrovasculares foi observado no grupo II, incluindo retinopatia, neuropatia e angina instável. A análise de regressão multivariada revelou que peso corporal aumentado, e níveis elevados de glicemia de jejum, hemoglobina glicada e lipoproteína de baixa densidade foram fatores de risco independentes de desfechos microvasculares e macrovasculares.Conclusões: Em pacientes pré-diabéticos, o JI, combinado com DLC, associou-se com menor progressão para diabetes mellitus e menor incidência de complicações microvasculares e macrovasculares.

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Section: Discussionsupporting

confidence: 93%

Section: Artigo Originalunclassified

Papel do Jejum Intermitente e da Dieta Restrita em Carboidratos na Prevenção de Doenças Cardiovasculares em Pacientes Pré-Diabéticos

Khalfallah¹,

Elnagar²,

Soliman³

et al. 2023

Arquivos Brasileiros De Cardiologia

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“…In a mouse model of pre-diabetes, alternate day fasting attenuated ROS production and reduced peripheral nerve damage. 234 Clinical studies in aging volunteers report salutary effects of long-term dietary interventions on brain health. 235 , 236 In older adults free from metabolic disorder and memory impairments, participants assigned to a 30% reduced calorie diet for 3 months exhibited improved memory scores compared to the control diet group.…”

Section: Emerging Directions For Interventionsmentioning

confidence: 99%

Current Perspectives: Obesity and Neurodegeneration - Links and Risks

Kueck,

Morris,

Stanford

2024

DNND

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Obesity is increasing in prevalence across all age groups. Long-term obesity can lead to the development of metabolic and cardiovascular diseases through its effects on adipose, skeletal muscle, and liver tissue. Pathological mechanisms associated with obesity include immune response and inflammation as well as oxidative stress and consequent endothelial and mitochondrial dysfunction. Recent evidence links obesity to diminished brain health and neurodegenerative diseases such as Alzheimer’s disease (AD) and Parkinson’s disease (PD). Both AD and PD are associated with insulin resistance, an underlying syndrome of obesity. Despite these links, causative mechanism(s) resulting in neurodegenerative disease remain unclear. This review discusses relationships between obesity, AD, and PD, including clinical and preclinical findings. The review then briefly explores nonpharmacological directions for intervention.

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A detective story of intermittent fasting effect on immunity

2024

Immunology

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Intermittent fasting (IF) refers to periodic fasting routines, that caloric intake is minimized not by meal portion size reduction but by intermittently eliminating ingestion of one or several consecutive meals. IF can instigate comprehensive and multifaceted alterations in energy metabolism, these metabolic channels may aboundingly function as primordial mechanisms that interface with the immune system, instigating intricate immune transformations. This review delivers a comprehensive understanding of IF, paying particular attention to its influence on the immune system, thus seeking to bridge these two research domains. We explore how IF effects lipid metabolism, hormonal levels, circadian rhythm, autophagy, oxidative stress, gut microbiota, and intestinal barrier integrity, and conjecture about the mechanisms orchestrating the intersect between these factors and the immune system. Moreover, the review includes research findings on the implications of IF on the immune system and patients burdened with autoimmune diseases.

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Influence of intermittent fasting on prediabetes-induced neuropathy: Insights on a novel mechanistic pathway

Cited by 4 publications

References 62 publications

Papel do Jejum Intermitente e da Dieta Restrita em Carboidratos na Prevenção de Doenças Cardiovasculares em Pacientes Pré-Diabéticos

Papel do Jejum Intermitente e da Dieta Restrita em Carboidratos na Prevenção de Doenças Cardiovasculares em Pacientes Pré-Diabéticos

Current Perspectives: Obesity and Neurodegeneration - Links and Risks

A detective story of intermittent fasting effect on immunity

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