Influence of Intention to Adhere, Beliefs and Satisfaction About Medicines on Adherence in Solid Organ Transplant Recipients

Hugon, Amélie; Roustit, Matthieu; Lehmann, Audrey; Saint-Raymond, Christel; Borrel, Elisabeth; Hilleret, Marie‐Noëlle; Malvezzi, Paolo; Bedouch, Pierrick; Pansu, Pascal; Allenet, Benoît

doi:10.1097/tp.0000000000000221

Cited by 54 publications

(62 citation statements)

References 28 publications

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“…The TPB has been used for understanding adherence to medication in a wide range of medical contexts (Hagger et al, ; Hugon et al, ; Laba, Lehnbom, Brien, & Jan, ; Lee, Pincus, & Williams, ; McKinney, Modeste, Lee, & Gleason, ; Rich, Brandes, Mullan, & Hagger, ). More specifically, regarding adherence to oral antidiabetic medications, there are the studies of Farmer, Kinmonth, and Sutton (), and Guénette et al (), which evaluated only the beliefs (indirect determinants) towards the use of these medications.…”

Section: Introductionmentioning

confidence: 99%

Psychosocial determinants of adherence to oral antidiabetic medication among people with type 2 diabetes

Jannuzzi

Cornélio

São‐João

et al. 2020

Journal of Clinical Nursing

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Aims and objectives The aim of this study was to identify the psychosocial determinants of adherence to oral antidiabetic medication, according to the Theory of Planned Behaviour (TPB). Background Appropriate adherence to oral antidiabetic medication contributes to long‐term glycaemic control. However, glycaemic control is often poor in people with type 2 diabetes, mainly due to the poor adherence to oral antidiabetic agents. Design Prospective study with 2 waves of data collection, based on STROBE checklist was conducted. One hundred and fifty‐seven adults with type 2 diabetes, in chronic use of oral antidiabetic agents, composed the sample. At baseline, self‐reported measures of medication adherence (proportion and global evaluation of adherence) and of metabolic control (glycated haemoglobin) of diabetes were obtained. Methods The TPB main constructs (attitude, subjective norm and perceived control) and related beliefs were measured. Adherence and metabolic control measurements were obtained in a two‐month follow‐up (n = 157). Results Attitude and subjective norm, together, explained 30% of the variability in intention; their underlying belief‐based measures (behavioural and normative beliefs) explained 28% of the variability in intention. In addition, intention predicted behaviour at follow‐up. However, when added to the prediction model, past behaviour was the only explanatory factor of adherence behaviour. Conclusion Adherence behaviour to oral antidiabetic medication was predicted by intention, which, in turn, was determined by attitude and subjective norm. In order to promote adherence to oral antidiabetic agents, health professionals should include motivational strategies as well as strategies targeted to attitude and subjective norm when designing interventions. Relevance to clinical practice The nonadherence to antidiabetic medication contributes to lack of control of diabetes and ensuing complications. The comprehension of the factors explaining the variability in medication adherence can inform the design of theory‐based interventions aimed at promoting this behaviour.

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Section: Introductionmentioning

confidence: 99%

Psychosocial determinants of adherence to oral antidiabetic medication among people with type 2 diabetes

Jannuzzi

Cornélio

São‐João

et al. 2020

Journal of Clinical Nursing

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“…[46][47][48][49][50] Moreover, medical complexity, a history of non-adherence, and a history of non-adherence are all relative contraindications for transplant that typically require further assessments-leading to delays in listing. For instance, factors such as ethnicity, socioeconomic status, marital status, and employment status, and linguistic isolation all have been shown to have impact on the time to listing.…”

Section: Potential Covariatesmentioning

confidence: 99%

Substance use in kidney transplant candidates and its impact on access to kidney transplantation

Tang

Bansal

Famure

et al. 2019

Clinical Transplantation

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Background Due to the increasing public acceptance of substance use, it is important to understand the association between substance use and access to kidney transplant and its outcomes. Here, we assess the sociodemographic predictors of substance use and the association between substance use and KT access. Methods Predictors of substance use were examined using a multivariable‐adjusted multinomial logistic regression. The association between current substance use (tobacco and drug) and time from referral to listing or receipt of a KT was examined using Cox proportional hazards models. Results Of 2346 patients, the prevalence of current substance use was 17%. Predictors of current tobacco use were younger age, male sex, Caucasian ethnicity, being unemployed, and unmarried. Predictors of current drug use were younger age, male sex, Caucasian ethnicity, a history of non‐adherence, and a history of mental health disorder. Patients with tobacco use had a decreased likelihood of being cleared for KT (hazard ratio [HR]:0.83[0.70, 0.99]) and receiving a KT (HR:0.80 [0.66, 0.96]). No association was seen in this sample for patients with drug use (HR:0.88 [0.69, 1.11] for being cleared for KT and 0.88 [0.69, 1.14] for KT, respectively). Conclusions Tobacco use was associated with a decreased likelihood of access to KT whereas there was no statistically significant difference in access to KT between patients with or without drug use.

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“…RTX patients demonstrated the highest level of nonadherence to immunosuppressive drugs compared to other solid organ recipients . Nonadherence in this group may be related to side‐effects of medications, patients’ perception of the necessity and the perceived risk of drug dependency …”

Section: Introductionmentioning

confidence: 99%

“…ESRD patients have the highest daily pill burden in patients with chronic diseases, with an average of 12‐19 pills per day . Adherence is important to alleviate disturbing symptoms, prevent graft rejection in renal transplanted patients (RTX) and to prolong survival . However, adherence may be especially challenging in complicated treatment regimens with a heavy pill burden …”

Section: Introductionmentioning

confidence: 99%

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Beliefs about medicines in dialysis patients and after renal transplantation

Drangsholt

Cappelen

Lippe

et al. 2019

Hemodialysis International

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Introduction: Patients with end‐stage renal disease are burdened by a complex medication regimen, but little is known about the belief about medicine among dialysis‐ and renal transplant (RTX) patients. Patients’ beliefs about medicines may influence drug adherence and thereby affect morbidity and mortality. The aim of the present study was to assess the beliefs about medicine in dialysis as well as after RTX. Methods: In a prospective study, 301 dialysis patients were followed for up to 5.5 years during which time 142 had been transplanted. Out of the transplanted patients, 110 were eligible for inclusion. The Beliefs about Medicine Questionnaire (BMQ) was used to assess the beliefs in dialysis and after transplantation. BMQ in dialysis was also compared to that of the general Norwegian population (n = 426). Multiple linear regression analyses were performed with BMQ subscales as dependent variables and sociodemographic and clinical data as independent variables. Findings: Median age in dialysis was 62 (IQR 50‐73) years, 66.1% were male and 80.7% were treated with hemodialysis. When in dialysis, 98.2% strongly believed their medications were necessary, while 34.4% reported strong concerns. Furthermore, 17.3% believed their medications to be harmful and 38.6% believed that doctors overprescribed medicines. The Necessity‐concern differential had a positive score in 92.6% of the patients. Follow‐up time was 55 (IQR 50‐59) months. After transplantation, there was an increase in the patient‐reported necessity of medication (21.9 ± 2.7 vs. 23.8 ± 1.9, P < 0.001) compared to while in dialysis. Correlations were found between patient beliefs and education, age, and depression. Discussion: Although positive beliefs about medicines increase after transplantation, concerns are high in both dialysis and after RTX. Implementing the BMQ routinely in the clinical evaluation of dialysis‐ and RTX patients may help to identify patients with increased risk for medical nonadherence.

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Influence of Intention to Adhere, Beliefs and Satisfaction About Medicines on Adherence in Solid Organ Transplant Recipients

Abstract: Negative beliefs toward medications were shown to be an independent risk factor of poor adherence. Therefore, the BMQ could be an effective, easy to implement tool, for use in everyday practice, to identify patients needing interventions to improve adherence to IS.

Cited by 54 publications

References 28 publications

Psychosocial determinants of adherence to oral antidiabetic medication among people with type 2 diabetes

Psychosocial determinants of adherence to oral antidiabetic medication among people with type 2 diabetes

Substance use in kidney transplant candidates and its impact on access to kidney transplantation

Beliefs about medicines in dialysis patients and after renal transplantation

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