Influence of integrins on thrombus formation: a road leading to the unravelling of DVT

Ghosh, Nilabja; Garg, Iti; Srivastava, Swati; Kumar, Bhuvnesh

doi:10.1007/s11010-020-03961-x

Cited by 2 publications

(1 citation statement)

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“…Effects in keeping with the review are EIT followed by various mechanisms of hemorrhage (such as petechia rash and alveolar hemorrhage). Notably, a new side effect not previously suggested is that of deep vein thrombosis and diffuse thrombophlebitis, which, given Eptifibadtide's interference with integrin signaling, could be responsible given its likely disruption of the clotting cascade [ 59 ].…”

Section: Reviewmentioning

confidence: 99%

Adverse Drug Effect Profiles of Gp2b/3a Inhibitors: A Comparative Review of the Last Two Decades

Hasan,

Jauregui,

Zubair

et al. 2023

Cureus

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ST-Elevation Myocardial Infarction and non-ST Elevation Myocardial Infarction belong to the acute coronary syndrome group of diseases. These conditions are characterized by the complete or partial blockage of one or several coronary arteries, resulting in myocardial injury or necrosis. Various medications are used in their treatment, with the most recent addition being Glycoprotein IIb/IIIa inhibitors. They work by hindering the activity of glycoprotein IIb/IIIa receptors, which, in turn, prevents the clumping of platelets. Some of the GpIIb/IIIa inhibitors available in this category include abciximab, tirofiban, eptifibatide, roxifiban, and orbofiban. With this comprehensive literature review, we aimed to explore the potential adverse effects of these medications and compare the three in terms of their side effects profile. We searched through PubMed and Google Scholar and pinpointed 13 articles aligned with our inclusion criteria: six articles utilized eptifibatide, four were related to abciximab, and three used tirofiban. In 85% of the cases, a severe drop in platelet count, reaching as low as 1000/μL, was reported. Additionally, several other side effects were noted: one case documented multiple bruising spots appearing around the patient's body, two cases reported diffuse alveolar hemorrhage, and one case described a cardiac tamponade resulting from hemorrhagic pericarditis. Our study highlights the crucial significance of keeping a watchful eye on and comprehending the potential drawbacks linked to these medications in cardiovascular treatment. The necessity of researching these medications and their side effects is also evident, as this will significantly enhance the quality of treatment provided.

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Section: Reviewmentioning

confidence: 99%