Influence of insulin-like growth factor-binding proteins-2 and -3 in the pathogenesis of cystic ovarian disease in cattle

Rodríguez, Fernanda Mariel; Salvetti, Natalia Raquel; Panzani, Carolina G.; Barbeito, Claudio Gustavo; Ortega, Hugo Héctor; Rey, Florencia

doi:10.1016/j.anireprosci.2011.08.007

Cited by 26 publications

(21 citation statements)

References 58 publications

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“…However, numerous studies have shown that cysts are not simply inactive persistent structures but are in fact the contrary, still evolved, with important metabolic activity and structural changes , Monniaux et al 2008, Ortega et al 2008, Grado-Ahuir et al 2011, Rodríguez et al 2011. Also, other authors have found similar changes in the protein and mRNA expression of ESR2 isoforms in follicular cysts in women with polycystic ovary syndrome compared with normal size-matched follicles in healthy women (Jakimiuk et al 2002), and in prenatal testosterone-treated ovine females characterized by follicular persistence (Ortega et al 2009).…”

Section: Discussionmentioning

confidence: 62%

Alteration in localization of steroid hormone receptors and coregulatory proteins in follicles from cows with induced ovarian follicular cysts

et al. 2012

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Cystic ovarian disease (COD) is an important cause of infertility in cattle. The altered follicular dynamics and cellular differentiation observed in COD may be mediated through a disruption of the expression of steroid receptors and their associated transcriptional cofactors. The aim of this study was to determine the protein expression profiles of ESR1, ESR2, PGR, AR, NCOA3, NCOR2, and PHB2 (REA) in ovarian follicles in an experimental model of COD induced by the administration of ACTH. Ovaries were collected and follicles were dissected from heifers during the follicular phase (control) or from heifers treated with ACTH to induce the formation of ovarian follicular cysts. Ovaries were fixed, sectioned, and stained immunohistochemically for steroid receptors and the associated transcription factors. The relative expression of ESR1 was similar in follicular cysts and in tertiary follicles from both control and cystic cows and was significantly higher than in secondary follicles. The expression of ESR2 in the granulosa was higher in cystic follicles. No differences were seen for PGR. The expression of androgen receptor was significantly increased in tertiary follicles with lower immunostaining in cysts. The expression of NCOA3 was observed in the granulosa and theca with a significantly increased expression in the theca interna of cystic follicles. The highest levels of NCOR2 expression in granulosa, theca interna, and theca externa were observed in cysts. In granulosa cells, NCOR2 levels increase progressively as follicles mature and the treatment had no effect. In summary, ovaries from animals with induced COD exhibited altered steroid receptor expression compared with normal animals, as well as changes in the expression of their regulators. It is reasonable to suggest that in conditions characterized by altered ovulation and follicular persistence, such as COD, changes in the intra-ovarian expression of these proteins could play a role in their pathogenesis.

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Section: Discussionmentioning

confidence: 62%

Alteration in localization of steroid hormone receptors and coregulatory proteins in follicles from cows with induced ovarian follicular cysts

et al. 2012

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“…The high levels of BMP4 and BMP6 in ovaries from animals with spontaneous COD and progesterone-induced follicular persistence can contribute to this imbalance, which eventually results from the sum of many local and general factors (Amweg et al 2013, Díaz et al 2015. We have noted previously that other members of the TGF-β and IGF systems are altered in the ovaries of animals with COD (Ortega et al 2008, Rodríguez et al 2011, 2013. Such hormonal imbalance could affect, among others, the balance between proliferation and apoptosis and between pro-and anti-apoptotic factors in ovarian follicles of animals with COD.…”

Section: Discussionmentioning

confidence: 99%

BMP2, 4 and 6 and BMPR1B are altered from early stages of bovine cystic ovarian disease development

et al. 2016

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“…Se han documentado variaciones en las concentraciones de las IGFBPs en LF durante el crecimiento y desarrollo folicular en bovinos (de la Sota et al, 1996;Stewart et al, 1996), ovinos (Perks y Wathes, 1996), y cerdos (Yuan et al, 1996). Rodríguez et al (2011; encontraron expresión de IGFBP2, 3, 4 y 5 en células de la granulosa de folículos en desarrollo y en quistes. En folículos quísticos se encontraron los menores niveles de expresión génica y proteica para IGFBP3.…”

Section: Expresión De Los Diferentes Componentes Del Sistema Igf En Lunclassified

“…Sin embargo, es la proteína con más actividad detectada en LF lo que estaría indicando que la acción local de IGBP3 no es producto de la síntesis in situ sino que podría haber una contribución sistémica (Wathes et al, 2003;Santiago et al, 2005;Rodríguez et al, 2013). Los niveles de expresión de IGFBP2, 4 y 5 detectados en quistes son similares a los observados en folículos controles (Rodríguez et al, 2011;. Por otro lado, existe una disminución en la actividad de IGFBP4 y 5 en la medida que ocurre el crecimiento del folículo, determinando la menor actividad en los quistes (Monget et al, 1993, Spicer, 2004, Aad et al, 2006Rodríguez et al, 2013).…”

Section: Expresión De Los Diferentes Componentes Del Sistema Igf En Lunclassified

“…A nivel intraovárico los IGFs constituyen importantes reguladores del crecimiento, desarrollo y selección folicular, atresia, diferenciación celular o esteroidogéne-sis; por lo que una falla en la regulación de dicho sistema puede ocasionar alteraciones en el ciclo estral normal y conducir a importantes problemas reproductivos (Ortega et al, 2008;Rey et al, 2010;Rodríguez et al, 2011;2015). Una importante causa de infertilidad en el bovino es la enfermedad quística ovárica (COD).…”

Section: Introductionunclassified

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Participación del sistema IGF en la patogenia de la enfermedad quística bovina

Rodríguez¹,

Salvetti²,

Ortega³

et al. 2016

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La enfermedad quística ovárica (COD) es una de las principales causas de falla reproductiva y de infertilidad, y constituye uno de los de los trastornos reproductivos más frecuentes en vacas lecheras de alta producción. El desarrollo de esta enfermedad está asociado a un desequilibrio en el eje hipotalámico-hipofisario-gonadal en el cual factores endocrinos, entre ellos el sistema de factores de crecimiento análogos a insulina (IGF), participan en el desarrollo folicular, diferenciación celular y la secreción de hormonas ováricas. Considerando al sistema IGF como un importante regulador del crecimiento y funcionalidad folicular, evaluamos la participación de componentes del sistema IGF en el desarrollo de la COD. Las alteraciones en diferentes componentes del sistema IGF que podrían afectar al normal funcionamiento del ovario participando en el desarrollo de la COD en bovinos.

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Influence of insulin-like growth factor-binding proteins-2 and -3 in the pathogenesis of cystic ovarian disease in cattle

Cited by 26 publications

References 58 publications

Alteration in localization of steroid hormone receptors and coregulatory proteins in follicles from cows with induced ovarian follicular cysts

Alteration in localization of steroid hormone receptors and coregulatory proteins in follicles from cows with induced ovarian follicular cysts

BMP2, 4 and 6 and BMPR1B are altered from early stages of bovine cystic ovarian disease development

Participación del sistema IGF en la patogenia de la enfermedad quística bovina

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