Influence of infection during pregnancy on fetal development

Waldorf, Kristina M. Adams; McAdams, Ryan M.

doi:10.1530/rep-13-0232

Cited by 265 publications

(209 citation statements)

References 100 publications

(103 reference statements)

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“…Management changes included early surfactant replacement, low-volume ventilation, tolerance to moderate elevation in PCO 2 , and limiting exposure to high inspired O 2 fraction levels. Thus the approaches used to create BPD in the 140-day model for BPD did not reflect current therapy, minimizing the clinical relevance of the 140-day model.…”

Section: -Day Model ("New" Bpd)mentioning

confidence: 99%

“…Factors frequently contributing to this proinflammatory state include fetal and postnatal nutritional deficiencies, oxygen toxicity, volutrauma associated with invasive mechanical ventilation, and fetal and postnatal infections. The importance of perinatal infection in the pathogenesis of BPD, both fetal and neonatal, and particularly associated with Ureaplasma/ Mycoplasma organisms, has been recently highlighted (2,48,67,76,84). The incorporation of this perinatal infection into the primate model of preterm birth and BPD has been perhaps the most important new addition to models of BPD over the past decade.…”

Section: Bpd Inflammation and Infectionmentioning

confidence: 99%

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Animal models of bronchopulmonary dysplasia. The preterm baboon models

Yoder

Coalson

2014

American Journal of Physiology-Lung Cellular and Molecular Phys

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Yoder BA, Coalson JJ. Animal models of bronchopulmonary dysplasia. V. The preterm baboon models. Am J Physiol Lung Cell Mol Physiol 307: L970 -L977, 2014. First published October 3, 2014 doi:10.1152/ajplung.00171.2014.-Much of the progress in improved neonatal care, particularly management of underdeveloped preterm lungs, has been aided by investigations of multiple animal models, including the neonatal baboon (Papio species). In this article we highlight how the preterm baboon model at both 140 and 125 days gestation (term equivalent 185 days) has advanced our understanding and management of the immature human infant with neonatal lung disease. Not only is the 125-day baboon model extremely relevant to the condition of bronchopulmonary dysplasia but there are also critical neurodevelopmental and other end-organ pathological features associated with this model not fully discussed in this limited forum. We also describe efforts to incorporate perinatal infection into these preterm models, both fetal and neonatal, and particularly associated with Ureaplasma/Mycoplasma organisms. Efforts to rekindle the preterm primate model for future evaluations of therapies such as stem cell replacement, early lung recruitment interventions coupled with noninvasive surfactant and high-frequency nasal ventilation, and surfactant therapy coupled with antioxidant or anti-inflammatory medications, to name a few, should be undertaken.baboon; bronchopulmonary dysplasia; lung; preterm infant; ureaplasma OF THE NEARLY 4,000,000 annual births in the United States, ϳ1% (ϳ40,000) occur at Ͻ29-wk gestation. Advances in prenatal and neonatal care have contributed to marked improvements in survival rates for these extremely immature infants, with many centers reporting survival rates Ͼ90% for infants in the 25-to 28-wk range (71). However, increasing survival of these fragile infants has been accompanied by high rates of bronchopulmonary dysplasia (BPD), the most common morbidity affecting extremely preterm infants (66,71,96). Much of the progress in improved neonatal care, particularly management of underdeveloped preterm lungs, including approaches to mechanical ventilation, surfactant therapy, and application of noninvasive respiratory support, has been derived through investigations of multiple animal models, including the neonatal baboon (Papio species). In this article we will highlight how primate models, particularly the preterm baboon model at both 140 days and 125 days gestation (term equivalent 185 days), have advanced our understanding and management of the immature human infant with neonatal lung disease; identify limitations to this and other animal models in the quest to prevent BPD; and suggest future directions to improve animal modeling and translational research to further improve outcomes. 140-Day Model ("Old BPD")The first long-term animal model for neonatal BPD in the 140-day premature baboon was developed in the early 1980s (19,26). At that time surfactant replacement therapy had not been approved for human use. Additi...

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Section: -Day Model ("New" Bpd)mentioning

confidence: 99%

Section: Bpd Inflammation and Infectionmentioning

confidence: 99%

Animal models of bronchopulmonary dysplasia. The preterm baboon models

Yoder

Coalson

2014

American Journal of Physiology-Lung Cellular and Molecular Phys

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“…Important issues related to the period of pregnancy and the time preceding this period include the risks for the mother and the foetus resulting from infections with TORCH pathogens, which include Toxoplasma gondii, Rubella virus, Cytomegalovirus (CMV) and other pathogens associated with the generation of congenial birth defects [2,3,4,5]. If a pregnant woman becomes ill with rubella, this may lead to the intrauterine foetal infection with Rubella virus and the occurrence of the congenital rubella syndrome, which involves a range of serious birth defects.…”

Section: Introductionmentioning

confidence: 99%

Knowledge of Nursing Students About the Transmission And Prevention of Infections Caused by Toxoplasma Gondii , Rubella Virus , Cytomegalovirus in Women During Pregnancy

Eliašová¹,

Tokarska-Rodak²,

Laskowski³

et al. 2017

hpc

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“…"Others" are, as follows: treponema pallium, listeria monocytogenes, parvovirus B19, varicella zoster virus, measles virus, myxovirusparotitis, influenza virus, viruses such as: HIV,HCV,HBC and also chlamydia trachomatis, and plasmodium falciparum [1,2]. These pathogens are not only responsible for developing certain clinical symptoms in pregnant women but also have significant influence on child's health.…”

Section: Introductionmentioning

confidence: 99%

“…The consequences of TORCH infections may lead to foetal death, development of congenital disorders or damages which may be visible in children directly after the birth, during infancy, or become present later, after several years. The most serious consequences are caused by foetal infection during early pregnancy [1,2].…”

Section: Introductionmentioning

confidence: 99%