Influence of industrial sources on children's health – Hot spot studies in North Rhine Westphalia, Germany

Wilhelm, Michael; Eberwein, Georg; Hölzer, Jürgen; Gladtke, Dieter; Angerer, Jürgen; Marczyński, Boleslaw; Behrendt, Heidrun; Ring, Johannes; Sugiri, Dorothee; Ranft, Ulrich

doi:10.1016/j.ijheh.2007.02.007

Cited by 68 publications

(34 citation statements)

References 13 publications

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“…Our observation is consistent with well-known published data [3,[9][10][11]. The vicinity of the source of environmental hazards is one of accepted methods of indirect measurement of exposure [12][13][14] and is often used in environmental epidemiology [15][16][17].…”

Section: Resultssupporting

confidence: 92%

The determinants of lead and cadmium blood levels for preschool children from industrially contaminated sites in Poland

Kowalska

Kulka

Jarosz

et al. 2017

Int J Occup Med Environ Health

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Objectives: Industrially contaminated sites (ICS) represent an important public health issue in European countries. The Silesian Voivodeship, the region located in the southern part of Poland, the historical center of industry, has many sites that meet ICS criteria. Most of them are landfills containing lead, cadmium and zinc. Material and Methods: The aim of the study has been to evaluate determinants of lead and cadmium blood levels for preschool children living in the vicinity of selected environmental hazards in Piekary Śląskie, the city located in the region of Silesia. Data about exposure was obtained from the parental questionnaire and was verified by levels of biomarkers in children's blood. Finally, 678 preschool children were studied. Results: Obtained results have confirmed that the statistically significant higher level of lead in blood has been revealed in the case of younger children whose fathers have a higher level of education and whose mothers smoke cigarettes at home, as well as for those living in the vicinity of any environmental hazard. In the case of cadmium, a higher level of the biomarker has been reported for older children who rather do not live close to any environmental hazard. We have recognized 30% of children with blood lead level (PbB) exceeding 2 μg/dl and 0.8% of children with blood cadmium level (CdB) exceeding the reference value (0.5 μg/l). Conclusions: Own observation has confirmed that preschool children living in Piekary Śląskie are still exposed to heavy metals existing in environment. The source of the higher level in blood is not only the hazardous vicinity in the place of residence but also well-known factors associated with the age of children, parental life style and educational background. The parental questionnaire could be useful to identify potential determinants of exposure to lead and cadmium, however exposure must be verified by measurement of a proper biomarker. Int J Occup Med Environ Health 2018;31(3): 351 -359

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Section: Resultssupporting

confidence: 92%

The determinants of lead and cadmium blood levels for preschool children from industrially contaminated sites in Poland

Kowalska

Kulka

Jarosz

et al. 2017

Int J Occup Med Environ Health

View full text Add to dashboard Cite

show abstract

“…It is notable that rather few environmental studies have made measurements of exposure, either through chemical analysis of air or diet, or by questionnaire in relation to diet. Several have used a cross-sectional design in which subjects from areas deemed to be more polluted are compared to groups from less polluted areas (Vyskocil et al 2000;Wilhelm et al 2007;Lee et al 2007;Hansen et al 2005). This can provide useful insights into relative exposures, but does not quantify the contribution of different pathways to intake.…”

Section: Introductionmentioning

confidence: 99%

Urinary metabolites of polycyclic aromatic hydrocarbons in Saudi Arabian schoolchildren in relation to sources of exposure

Alghamdi

Alam

Stark

et al. 2015

Environmental Research

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Polycyclic aromatic hydrocarbons contain a number of known carcinogenic compounds, and urinary biomarkers have been widely used as a measure of exposure but quantitative relationships with exposure variables have proved elusive. This study aimed to quantify the relationship between exposures to phenanthrene and pyrene from atmospheric and dietary sources with the excretion of 1-hydroxypyrene and hydroxyphenanthrenes in urine as biomarkers of exposure. The study population consisted of 204 male schoolchildren attending three schools in different parts of Jeddah, Saudi Arabia who provided urine samples on each of three consecutive days. Outdoor air measurements of polycyclic aromatic hydrocarbons were made at the schools and the children provided information on diet, exposure to environmental tobacco smoke and incense, and various lifestyle factors through a questionnaire. Mixed models with random effects for subjects nested within site were fitted in order to examine the relationship between exposure variables and urinary PAH metabolites. A unit increase (1 ng m(-3)) in ambient pyrene (particulate plus gaseous phase) was associated with a 3.5% (95% CI: 1.01%, 5.13%) increase in urinary 1-hydroxypyrene concentration. A unit increase in ambient phenanthrene was associated with a 1.01% (95% CI: 0.03%, 2.02%) increase in total hydroxyphenanthrene concentrations. Consumption of chargrilled food increased the 1-hydroxypyrene and hydroxyphenanthrene concentrations by 24% (95% CI: 11%, 37%) and 17% (95% CI: 8%, 26%) respectively. We did not find evidence of association for environmental tobacco smoke exposure or incense burning. It is concluded that both respiratory exposure and consumption of chargrilled food are considerable sources of PAH exposure in this population as reflected by concentrations of urinary biomarkers.

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“…No difference was seen in % tail DNA in leukocytes of either maternal or cord blood [15]. Human biomonitoring studies were also carried out in North Rhine-Westphalia, Germany where a 3.5-fold increase was found in DNA SBs in lymphocytes of children living near a coke oven plant in Duisburg North, compared with children from a rural area [20].…”

Section: Discussionmentioning

confidence: 99%

Atmospheric pollution in Kosovo is associated with increased DNA damage in the human population

Alija¹,

Asllani²,

Bajraktari³

et al. 2016

Biomonitoring

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Abstract:In order to assess DNA damage associated with exposure to environmental pollution in two polluted sites and one control site in Kosovo, whole blood samples were collected from volunteers in two polluted areas (Kastriot/ Obiliq - lignite-based power plants and lignite mines - and Drenas/Gllogovc - Ferronikeli smelting plant) as well as from Peja, representing an unpolluted area. White blood cells were isolated, and DNA damage was analyzed by the alkaline comet assay. Significantly higher levels of DNA damage (strand breaks) were found in white blood cells from subjects living in the polluted areas compared with residents of the unpolluted city, indicating a potential threat to human health.

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Influence of industrial sources on children's health – Hot spot studies in North Rhine Westphalia, Germany

Cited by 68 publications

References 13 publications

The determinants of lead and cadmium blood levels for preschool children from industrially contaminated sites in Poland

The determinants of lead and cadmium blood levels for preschool children from industrially contaminated sites in Poland

Urinary metabolites of polycyclic aromatic hydrocarbons in Saudi Arabian schoolchildren in relation to sources of exposure

Atmospheric pollution in Kosovo is associated with increased DNA damage in the human population

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