Influence of Individual Characteristics on Outcome of Glycemic Control in Intensive Care Unit Patients With or Without Diabetes Mellitus

Evidence‐based sepsis therapy: A hospitalist perspective

“…Retrospective studies suggested the upper limit for target blood glucoses could be 145 mg/dL 63 and found differing thresholds at which hyperglycemia increased mortality in nondiabetics (144 mg/dL) and diabetics (200 mg/ dL). 64 However, in the surgical ICU trial, there was no threshold below which there was no further reduction in risk; patients whose mean blood glucose was below 110 mg/dL had lower mortality than those whose levels were between 110 and 150 mg/dL (P ϭ .026). 65 Finally, the effects of hyperglycemia and intensive insulin may vary by population: retrospective studies found that ICU hyperglycemia was more strongly associated with mortality among nondiabetics, 64,66 and van den Berghe et al noted no benefit from intensive insulin in a small subgroup of diabetics.…”

“…64 However, in the surgical ICU trial, there was no threshold below which there was no further reduction in risk; patients whose mean blood glucose was below 110 mg/dL had lower mortality than those whose levels were between 110 and 150 mg/dL (P ϭ .026). 65 Finally, the effects of hyperglycemia and intensive insulin may vary by population: retrospective studies found that ICU hyperglycemia was more strongly associated with mortality among nondiabetics, 64,66 and van den Berghe et al noted no benefit from intensive insulin in a small subgroup of diabetics. 59 In summary, large, well-designed trials have demonstrated that intensive insulin reduced mortality in critically ill patients after a delay of 3-5 days, but this benefit did not extend to all patients in the medical ICU.…”

A call for routine outcome monitoring in Iran

“…7 For psychiatry, ROM has been implemented in several countries, but not all of them could overcome these difficulties. Pharmacotherapy Monitoring and Outcome Survey (PHAMOUS) is a good example of ROM that was started in 2006 to improve the quality of care for patients with psychotic disorders in the Northern Netherlands.…”

Diabetic polyneuropathy is associated with respiratory muscle impairment in type 2 diabetes

“…In addition, diabetes has a major negative impact on intensive care unit outcome [5,6], including prolonged weaning from mechanical ventilation [7]. Clinical observation also indicates that diabetes is associated with a markedly increased risk of developing respiratory failure [8].…”