Influence of in vitro micropropagation on lycorine biosynthesis and anticholinesterase activity in Hippeastrum goianum

Costa, Gabriella Gusmão Pereira da; Silva, Cristian Aldemar Gasca; Gomes, João Victor Dutra; Torres, Amanda Gomes; Santos, I. R. I.; Almeida, Francisco A. G.; Fagg, Christopher William; Simeoni, Luiz Alberto; Silveira, Dâmaris; Gomes-Copeland, Kicia Karinne Pereira

doi:10.1016/j.bjp.2019.02.001

Cited by 15 publications

(8 citation statements)

References 13 publications

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“…The Hippeastrum genus contains approximately 94 species native of tropical and subtropical regions of the America [92]. One new alkaloid named 2α-10bα-dihydroxy-9-O-demethylhomolycorine (29), belonging to homolycorine-type and seven known alkaloids were isolated from the bulbs of Hippeastrum solandriflorum.…”

Section: X-other-typesmentioning

confidence: 99%

Biosynthesis and Biological Activities of Newly Discovered Amaryllidaceae Alkaloids

Koirala

Mérindol

et al. 2020

Molecules

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Alkaloids are an important group of specialized nitrogen metabolites with a wide range of biochemical and pharmacological effects. Since the first publication on lycorine in 1877, more than 650 alkaloids have been extracted from Amaryllidaceae bulbous plants and clustered together as the Amaryllidaceae alkaloids (AAs) family. AAs are specifically remarkable for their diverse pharmaceutical properties, as exemplified by the success of galantamine used to treat the symptoms of Alzheimer’s disease. This review addresses the isolation, biological, and structure activity of AAs discovered from January 2015 to August 2020, supporting their therapeutic interest.

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Section: X-other-typesmentioning

confidence: 99%

Biosynthesis and Biological Activities of Newly Discovered Amaryllidaceae Alkaloids

Koirala

Mérindol

et al. 2020

Molecules

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“…Previous studies have investigated the phytochemical profile of plant species [ 31 , 32 , 33 ] or the variation in this profile and the relative abundance of the target compound for the same species, varying the method of propagation and extraction, and the composition of the culture medium or plant part used [ 9 , 13 , 27 , 33 ]. In contrast with these, the present study used AC to evaluate whether the interaction with sucrose at different concentrations would result in a variation in relative abundances for the same target compound.…”

Section: Discussionmentioning

confidence: 99%

“…Recent studies with Amaryllidaceae species have shown that propagation methods [ 9 ] and the plant habitat [ 10 ] can alter phytochemistry, varying the abundance of secondary metabolites for the same species. Many in vitro propagation studies evaluated the influence of culture medium composition on the seedling phytochemistry and opted to vary the type and concentration of the carbohydrate source, with sucrose being the most common [ 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

“…According to the literature [ 13 ], increasing the concentration of sucrose in the culture medium up to 90 gL −1 increases the biomass of some Amaryllidaceae species. However, few have evaluated phytochemistry from seed propagation [ 9 ] and the interaction of sucrose with activated charcoal on vegetative growth and phytochemistry. We expect that in addition to effects of sucrose, the activated charcoal can modify the biomass increase rate and the phytochemistry due to its adsorption capacity [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

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Influence of Sucrose and Activated Charcoal on Phytochemistry and Vegetative Growth in Zephyranthes irwiniana (Ravenna) Nic. García (Amaryllidaceae)

Dewes Neto,

Gomes-Copeland,

Silveira

et al. 2024

Plants

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Zephyranthes irwiniana (Ravenna) Nic. García is an endemic, red list threatened species from the Brazilian savanna (Cerrado) with pharmacological potential to treat the symptoms of Alzheimer’s Disease (AD). This work analyzed the vegetative growth and phytochemistry of its potential compounds, in response to variations in sucrose concentration and activated carbon (AC). Seeds were germinated in vitro and in the greenhouse. The in vitro bulbs were separated in six treatments with different sucrose concentrations (30, 45 and 60 gL−1) and/or AC (1 gL−1). Biomass increases in individuals grown in the greenhouse were higher than those cultivated in vitro. Sucrose concentration significantly increased biomass and root number. AC had a positive influence on leaf and root size, and a negative influence on root number. GC–MS analyses indicated great variation in the abundance of α-terpenyl-acetate, ethyl linoleate, clionasterol and lycorine between treatments, with maximum concentrations of 53.06%, 38.68, 14.34% and 2.57%, respectively. Histolocalization tests indicated the presence of alkaloids in the leaf chlorenchyma and bulb cataphylls. Finally, the present study provided new evidence that the constitution of the culture medium directly influences the vegetative growth and phytochemistry of this species, providing a good medium condition for propagating the species under threat.

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“…Lycorine ( 1 ), 7-demethoxy-9- O -methylhostasine ( 47 , Figure 3 ), and rutin were identified in the Hippeastrum stapfianum leaf extract [ 41 ]. This Amaryllidacea is an endemic species from the Brazilian savannah with biological and pharmacological activities, including AChE inhibition showing IC 50 values ranging between 386.00 ± 0.97 and 114.80 ± 0.95 µg/mL [ 42 ]. Their potential for the treatment of Alzheimer’s disease is based on the ability of the plant extract to activate PPAR-α (peroxisome proliferator-activated receptor alpha) and PPAR-γ (peroxisome proliferator-activated receptor gamma) selectively [ 41 ].…”

Section: Alkaloids Isolated From Amaryllidacae Plants Collected In An...mentioning

confidence: 99%

Advances on the Amaryllidacea Alkaloids Collected in South Africa, Andean South America and the Mediterranean Basin

Evidente

2023

Molecules

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The alkaloids are one of the most represented family of natural occurring biological active compounds. Amaryllidaceae are also very well known for their beautiful flower and are thus used as ornamental plants in historic and public gardens. The Amaryllidacea alkaloids constitute an important group that is subdivided into different subfamilies with different carbon skeletons. They are well known from ancient times for their long application in folk medicine, and in particular, Narcissus poeticus L. was known to Hippocrates of Cos (ca. B.C. 460–370), who treated uterine tumors with a formulate prepared from narcissus oil. To date, more than 600 alkaloids of 15 chemical groups exhibiting various biological activities have been isolated from the Amaryllidaceae plants. This plant genus is diffused in regions of Southern Africa, Andean South America and the Mediterranean basin. Thus, this review describes the chemical and biological activity of the alkaloids collected in these regions in the last two decades as weel those of isocarbostyls isolated from Amaryllidaceae in the same regions and same period.

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Influence of in vitro micropropagation on lycorine biosynthesis and anticholinesterase activity in Hippeastrum goianum

Cited by 15 publications

References 13 publications

Biosynthesis and Biological Activities of Newly Discovered Amaryllidaceae Alkaloids

Biosynthesis and Biological Activities of Newly Discovered Amaryllidaceae Alkaloids

Influence of Sucrose and Activated Charcoal on Phytochemistry and Vegetative Growth in Zephyranthes irwiniana (Ravenna) Nic. García (Amaryllidaceae)

Advances on the Amaryllidacea Alkaloids Collected in South Africa, Andean South America and the Mediterranean Basin

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