Dental implants are a predictable treatment option for intra-oral prosthetic reconstruction. The survival rates of osseointegrated dental implants are 89.2 -95.5%, as reported in systematic review over the last 5 years. 1 The stability of bone level around dental implants is one of the important factors in long-term implant success. However, certain biological and technical complications may lead to implant failure and peri-implant bone loss. 2,3 Previous periodontal disease, poor plaque control, smoking, and diabetes are included as risk factors that may lead to periimplant mucositis and peri-implantitis, as reported by the American Academy of Periodontology. 4 In patients with a history of periodontitis, however, preventive maintenance programs can reduce the incidence of peri-implantitis. 5,6 In four systematic reviews, smoking was described as a negative factor in implant outcome and affects survival rate and marginal bone loss. 7-10 However, other studies found no significant relationship between smoking and im- Purpose: The purpose of this study was to compare the long-term survival rate and peri-implant marginal bone loss related to multiple risk factors including the clinician's experience. Materials and Methods: Four hundred twenty implants in 146 patients, who had involved a supportive periodontal therapy program every 3 to 6 months and had follow up data for at least 5 years, were selected as the study group. Peri-implant marginal bone loss, data of demographic, implant and surgical characteristics were collected from peri-apical radiographs and chart review. Implant survival was regarded as the remaining with radiographic marginal bone level in excess of 50% of the fixture length for any reason. Results: The cumulative survival rate after 5 years of loading was 94.9%. In binary logistic regression analysis, smoking status (P = 0.033) and presence of spontaneous cover screw exposure (P < 0.001) were significantly related to 5-year survival of implants. In stepwise multiple regression analysis, smoking status (P < 0.001), type of abutment connection (P < 0.001) and implant surface (P = 0.033) were significantly related to peri-implant marginal bone level. And the year of resident was not statistically related to 5-year implant survival in simple logistic regression analysis (P = 0.171).