Influence of imaging and histological factors on prostate cancer detection and localisation on multiparametric MRI: a prospective study

Abstract

• Prostate cancer volume, Gleason score, architecture and location are MRI predictors of detection. • Field strength and coils used do not influence the tumour detection rate. • Multiparametric MRI is accurate for detecting aggressive tumours. • A subjective suspicion score can stratify the risk of malignancy and tumour aggressiveness.

Correlation of Clinical Risk Factors with Diffusion-Weighted Magnetic Resonance Images in Prostate Cancer Patients Treated with Definitive Radiotherapy

“…27 These cellular and structural differences exist between low-and high-risk lesions, and they can be measured non-invasively in vivo using DW-MRI, which constructs images based on quantifying water molecule diffusion within tissues. 28 The ADC is a quantitative parameter of the extent of water molecule diffusion.…”

“…However, on post-biopsy T2W images, hemorrhage has low signal intensity that can mimic the tumor and lead to inaccurate measurements. 27 In previous studies analyzing the importance of ADC in prostate cancer patients 22,23 , the MRI scans were delivered before prostate biopsy, which makes the result more accurate. We evaluated the patients before initiation of RT, and MRI scans were all taken before RT with biopsy proven prostate cancer.…”

Three-dimensional proton magnetic resonance spectroscopy and diffusion-weighted imaging in the differentiation of incidental prostate carcinoma from benign prostate hyperplasia

“…The results of prior studies (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12) indicate that the apparent diffusion coefficient (ADC) value of malignant regions was lower than that of the benign regions, and the [choline (Cho) + creatine (Cre)]/citrate (Cit) (CC/C) value of the former was higher than the latter.…”

“…There are a number of studies concerning the morphological and functional parameters of MRI on the CG and PZ of clinical prostate cancer (4)(5)(6)(7)(8)(9)(10)(11)(12); however, to the best of our knowledge, no public literature concerning MRS and DWI in IPCa in the CG of the prostate. The present study aimed to investigate the differences in conventional MRI manifestation, CC/C value, and ADC value between IPCa and BPH, and whether there are benefits to using these techniques to differentiate between the two diseases.…”

Dual-stage 18F-fluorocholine PET/CT scanning for biochemical recurrences of prostate cancer

“…Анализ результатов гистологического материала, по-лученного после РПЭ, показал как высокую чувстви-тельность мультипараметрической МРТ (включающей Т2-взвешенные изображения, диффузионно-взвешен-ные изображения (ДВИ), динамическое контрастное усиление и H1-спектроскопию) при РПЖ с суммой баллов по шкале Глисона (индекс Глисона) > 7, так и точность определения местной распространенности (пенетрации капсулы железы, прорастания семенных пузырьков и сосудисто-нервных пучков). При разме-рах опухолей < 0,5 см 3 и > 2,0 см 3 и индексе Глисона < 6 чувствительность, специфичность и точность МРТ-диагностики составили 21-29, 43-54 и 67-75 %, при индексе Глисона 7 -63, 82-88 и 97 %, индексе Глисо-на > 8 -80, 93 и 100 % соответственно [15][16][17][18][19]. МРТ имеет некоторые ограничения в диагностике местных рецидивов после простатэктомии -трудности при ин-терпретации изменений, связанных с геморрагически-ми и воспалительными процессами, артефакты от ме-таллических скрепок [19][20][21][22][23][24][25] (рис.…”