“…In this meta-analysis different case-control groups or cohorts in one publication were considered as independent total of 59 studies were included in this meta-analysis. There are seven studies with 1112 cases and 1233 controls on XRCC3 rs861539 (He et al, 2008;Xiao, 2009;Settheetham-Ishida et al, 2011;Djansugurova et al, 2013;Pérez et al, 2013;Al-Harbi et al, 2017), 14 studies with 2694 cases and 3349 controls MTHFR rs1801133 (Lambropoulos et al, 2003;Sull et al, 2004;Kang et al, 2005;Zoodsma et al, 2005;Delgado-Enciso et al, 2006;Ma et al, 2006;Nandan et al, 2008;Shekari et al, 2008;Kohaar et al, 2010;Yang et al, 2011;Prasad and Wilkhoo, 2011;Tong et al, 2011;Mostowska et al, 2011;von Keyserling et al, 2011), four studies with 1121 cases and 1109 controls on IL-12B rs3212227 (Chen et al, 2009;Do Carmo Vasconcelos De Carvalho et al, 2012;Roszak, Mostowska, et al, 2012), seven studies with 1452 cases and 2186 controls on IL-6 rs1800795 (Nogueira De Souza et al, 2006;Gangwar et al, 2009;Grimm et al, 2011;Shi et al, 2013;de Lima Júnior et al, 2016;Pu et al, 2016;Zidi et al, 2017), 20 studies with 4,781 cases and 4909 controls on TNF-α rs1800629 (Stanczuk et al, 2019;Jang et al, 2001;Calhoun et al, 2002;Gostout et al, 2003;…”