Influence of i.v. lipid emulsion on lipoprotein subclass in preterm infants

Suganuma, H; Ikeda, Naho; Ohkawa, Natsuki; Shoji, Hiromichi; Shimizu, Toshiaki

doi:10.1111/ped.13643

Cited by 1 publication

(1 citation statement)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Based on previous data we expected that nutrition and the type of feed might have confounded some or all of the changes seen in the significant lipid species identified, as infant feeding could alter the lipid profile in DBS [34,35]. In addition, breast milk and each type of formula milk have their own distinctive lipid profiles [36].…”

Section: The Impact Of Nutritionmentioning

confidence: 99%

Lipid Profiles from Dried Blood Spots Reveal Lipidomic Signatures of Newborns Undergoing Mild Therapeutic Hypothermia after Hypoxic-Ischemic Encephalopathy

Nixon

Jenkins

et al. 2021

Nutrients

View full text Add to dashboard Cite

Hypoxic-ischemic encephalopathy (HIE) is associated with perinatal brain injury, which may lead to disability or death. As the brain is a lipid-rich organ, various lipid species can be significantly impacted by HIE and these correlate with specific changes to the lipidomic profile in the circulation. Objective: To investigate the peripheral blood lipidomic signature in dried blood spots (DBS) from newborns with HIE. Using univariate analysis, multivariate analysis and sPLS-DA modelling, we show that newborns with moderate–severe HIE (n = 46) who underwent therapeutic hypothermia (TH) displayed a robust peripheral blood lipidomic signature comprising 29 lipid species in four lipid classes; namely phosphatidylcholine (PC), lysophosphatidylcholine (LPC), triglyceride (TG) and sphingomyelin (SM) when compared with newborns with mild HIE (n = 18). In sPLS-DA modelling, the three most discriminant lipid species were TG 50:3, TG 54:5, and PC 36:5. We report a reduction in plasma TG and SM and an increase in plasma PC and LPC species during the course of TH in newborns with moderate–severe HIE, compared to a single specimen from newborns with mild HIE. These findings may guide the research in nutrition-based intervention strategies after HIE in synergy with TH to enhance neuroprotection.

show abstract

Section: The Impact Of Nutritionmentioning

confidence: 99%