Influence of Helicobacter pylori Infection on the Small Intestinal Mucosa

Abstract

patients undergoing capsule endoscopy (CE) were tested for anti-H. pylori immunoglobulin G antibody (Hp-IgG) using an enzyme-linked immunosorbent assay (ELISA). None of the patients had been treated for H. pylori infection or diagnosed as having Crohn's disease or any other clinically apparent small intestinal disorders prior to the CE. Results. The overall Hp-IgG-positive rate was 26.3%. The incidence of enteritis, as diagnosed by CE, tended to be lower in the Hp-IgG-positive patients (23.1%) than in the Hp-IgG-negative patients (38.4%) ( = 0.140). When patients receiving aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs), well-known causes of enteritis, were excluded, the incidence of enteritis in the Hp-IgG-positive patients (11.7%) was significantly lower than that in the Hp-IgG-negative patients (43.7%) ( = 0.005). A binomial logistic regression analysis revealed a significant negative relationship between Hp-IgG positivity and the presence of enteritis in patients receiving neither aspirin nor NSAIDs ( = 0.017). Conclusions. Our data indicated that H. pylori positivity was inversely associated with the prevalence of enteritis.

Do Helicobacter Pylori Infection and Eradication Therapy Status Influence Weight Loss Outcomes and Endoscopic Findings After Roux-en-Y Gastric Bypass?a Historical Cohort Study

“…These mechanisms could generate a lower inflammatory response in the small intestine and, thus, be linked to some degree of protection against jejuna erosions (34,35) . Maeda et al (36) had previously hinted at this possible protective effect of HP on the small bowel mucosa against external injuries or inflammatory damage.…”