Influence of hypothalamic stimulation on the secretion of adrenal medullary catecholamines

Robinson, Robert L.; Culberson, James L.; Carmichael, Stephen W.

doi:10.1016/0165-1838(83)90026-7

Cited by 47 publications

(16 citation statements)

References 9 publications

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“…In agreement with our previous reports [5,6] and those of others [4], the most frequent adrenal medullary re sponse accompanying hypothalamic stimulation was an increase in the secretion ofboth EPI and NE. The signifi cant correlation between changes in EPI and NE suggests that hypothalamic stimulation primarily resulted in a gen eral activation of the adrenal medulla.…”

Section: Cns Stimulation and Ca Secretionsupporting

confidence: 82%

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Increases in Adrenolumbar Venous Flow and Epinephrine Secretion Elicited by Preoptic and Hypothalamic Stimulation in the Cat

Stoddard¹,

Bergdall²

1992

Neuroendocrinology

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Seventy-five sites were electrically stimulated within the preoptic and hypothalamic areas of anesthetized cats (n = 16). Adrenolumbar venous blood flow, secretion of epinephrine and norepinephrine, heart rate and mean arterial blood pressure were measured at baseline and following a standard stimulus (0.6 mA for 30 s) at each site. The most frequent adrenal medullary response to central stimulation was an increase in the secretion of both catecholamines (ng/min) > 10% of the baseline mean. Seventeen sites (23%) increased adrenolumbar venous flow > 12% above the mean baseline flow rate. This group of sites also evoked significantly greater increases in the secretion of epinephrine, and in mean arterial blood pressure and heart rate. These data support the hypothesis that secreted catecholamines, especially epinephrine, may act locally to increase blood flow through the adrenal medulla.

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Section: Cns Stimulation and Ca Secretionsupporting

confidence: 82%

“…As shown in table 2, how ever, some sites evoked preferential secretion of one or the other CA. The preferential secretion of either EPI or NE has previously been reported following stimulation of the hypothalamus [1,[4][5][6], spinal nucleus of the trigemi nal [14] and splanchnic nerve [18].…”

Section: Cns Stimulation and Ca Secretionmentioning

confidence: 99%

Increases in Adrenolumbar Venous Flow and Epinephrine Secretion Elicited by Preoptic and Hypothalamic Stimulation in the Cat

Stoddard¹,

Bergdall²

1992

Neuroendocrinology

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“…These two catecholamines are present in about equal amounts in the opossum adrenal, as shown by fluorometric analysis (see following paper). This is not the typical mammalian ratio, which is about 90% epinephrine in adult specimens (West, 1955), but it is similar to the cat, which has been used to advantage in some experiments because of the 1:l ratio of epinephrine and norepinephrine (Robinson et al, 1983).…”

Section: Discussionmentioning

confidence: 96%

Opossum adrenal medulla: I. Postnatal development and normal anatomy

et al. 1987

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The anatomy and histology of the adrenal gland in the adult opossum were found to be typical for mammals. The development of the adrenal medulla was also found to follow the typical mammalian pattern. Primitive sympathetic cells were found in both intra- and extra-adrenal locations in the newborn at a time when chromaffin precursor cells were migrating to the adrenal anlage. Pheochromoblasts first appeared within the forming medulla where at a later stage chromaffin cells could be observed forming columns of cells between adjacent sinusoids. Unlike in other mammals, much of this development takes place postnatally when the neonate is in the mother's marsupium. The value of the developing opossum adrenal medulla as an experimental model is stressed, since a significant amount of development takes place in an environment that is accessible to experimental manipulation.

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“…Prolongation of this disorder leads to exhaustion of DR-5HT but not MR-5HT neurons thus, predominance of the latter occurs during chronic stress situation. A bulk of information dealing with this issue has been quoted and affords support for the postulation that this pathophysiological mechanism should underlies in many diseases, like endogenous depression (Beaulieu et al, 1986;Lechin et al, 2006a,), TH-1 autoimmune diseases and EH, all of which frequently show exhaustion of adrenal glands activity plus disinhibition of the thymus gland secondary to the lowered levels of circulating cortisol (Herman et al, 2005;Huether 1996;Huether et al, 1996;Lovick 1993;Robinson et al, 1983). Summarizing all the above, DR-5HT hyperactivity is able to trigger labile hypertensive syndromes by the enhancement of the acute stress mechanisms but this type of physiological disorder travels in the opposite address of that which leads to the disorder underlying EH.…”

Section: Dorsal Raphe Serotonergic Nucleus and Essential Hypertensionmentioning

confidence: 94%

Central Nervous System Circuitry and Peripheral Neural Sympathetic Activity Responsible for Essential Hypertension

Lechín¹,

Dijs²

2006

CNR

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Both clinical and experimental studies dealing with patients affected by idiopathic or essential hypertension (EH) are devoted to the great deal of physiological, pharmacological and pathological as well as therapeutical issues of EH. However, most articles devoted to EH do not refer to the central nervous system mechanisms underlying this disease and the channels which allow that these mechanisms are funneled to the peripheral autonomic nervous system and trigger this cardiovascular disorder. In the present review article we attempted to reach this target devoted to the central nervous system circuitry involved in the cardiovascular pathophysiology. We postulated that EH depends on the predominance of the binomial A5 noradrenergic (NA) nucleus + median raphe serotonergic (5-HT) nucleus over the (A6)-NA + dorsal raphe-5HT nuclei. This hypothesis receives additional support from our results obtained throughout the neuropharmacological therapy of this type of neurophysiological disorder. Our therapeutical strategy is addressed to enhance the activity of the (A6)-NA + dorsal raphe-5HT binomial circuitry.

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Influence of hypothalamic stimulation on the secretion of adrenal medullary catecholamines

Cited by 47 publications

References 9 publications

Increases in Adrenolumbar Venous Flow and Epinephrine Secretion Elicited by Preoptic and Hypothalamic Stimulation in the Cat

Increases in Adrenolumbar Venous Flow and Epinephrine Secretion Elicited by Preoptic and Hypothalamic Stimulation in the Cat

Opossum adrenal medulla: I. Postnatal development and normal anatomy

Central Nervous System Circuitry and Peripheral Neural Sympathetic Activity Responsible for Essential Hypertension

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