Influence of Hypophysectomy on Gluconeogenesis in the Normal and Depancreatized Dog

Abstract

The APS Journal Legacy Content is the corpus of 100 years of historical scientific research from the American Physiological Society research journals. This package goes back to the first issue of each of the APS journals including the American Journal of Physiology, first published in 1898. The full text scanned images of the printed pages are easily searchable. Downloads quickly in PDF format.

Role of the Endocrines in the Regulation of Blood Sugar1

“…The analogous con-82 SAMUFX SOSKTN Volume 4 siderations apply to the liver as the organ* which makes the blood sugar. An example of a disturbance in sugar regulation, analogous to the situation in which the furnace is incapable of raising the temperature up to the level at which the thermostat is set, is the effect of fasting on the hypophysectomized animal and on the hypopituitary human (13). The withholding of food in the latter organisms results in a progressive hypoglycemia.…”

Effects of Total Hypophysectomy on the Glycemic and Plasma Cholesterol Levels in the Snake,Natrix piscator(Russell)

“…It is well known that the pituitary hormones have a regulatory influence on the carbohydrate metabolism (Houssay 1936(Houssay , 1942Houssay et al 1942 andDe Bod0 andAltszuler 1958). Hypophysectomy alone is known to produce a fall in blood sugar level in most vertebrate species examined (Mahoney 1934;Soskin et al 1935;Russell 1936;Slome 1936;Foglia ,et al 1955;Miller and Wurster 1958;Houssaf andPenhos 1960 andRangneker andSabnis 1966 a &b ) . Houssay (1942Houssay ( , 1959 and Some (1936) have noted that in toads the anterior pituitary has a diabetogenic action which is independent of the interrenal tissue.…”

The Staub-Effect in Diabetic Conditions and in Normal Rats

“…His explanation is still generally accepted. However, Soskin(1935)has opposed against this, because he recognized that the Staub-Effect in completely depancreatized dogs administered with a constant intravenous injections of insulin at rates just sufficient to maintain a normal constant blood sugar level.…”