Influence of hydroxypropyl methylcellulose, methylcellulose, gelatin, poloxamer 407 and poloxamer 188 on the formation and stability of soybean oil-in-water emulsions

Zhang, Miao; Yang, Baixue; Liu, Wei; Li, Sanming

doi:10.1016/j.ajps.2017.05.009

Cited by 30 publications

(26 citation statements)

References 42 publications

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“…An increase in the size of the gelatin was achieved by adjusting the concentration in aqueous droplets in the emulsion and thus the size of the final gelatin nanoparticles varies. [38] Surfactants also control the size of nanoparticles by reducing the size and the aggregation tendency of the gelatin droplets during emulsification process. [39] SEM was used to investigate the morphology as well as the particle size of nanoparticles.…”

Section: Discussionmentioning

confidence: 99%

Untitled

Jain¹

2017

IJGP

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Aim: The aim of this study to evaluates the physiochemical properties, drug loading, in vitro release, and anticancer study. Cancer is a group of diseases characterized by the uncontrolled growth and spread of abnormal cells. If the spread is not controlled, it can result in death. Docetaxel is used to treat primary breast cancer (cancer that started in the breast and has not spread to other parts of the body) in combination with other specific chemotherapy drugs. Docetaxel is also used alone or with other drugs to treat cancer that has spread to areas around the breast such as the lymph nodes above or below the collarbone (known as regional or locally advanced recurrence), or to other parts of the body (secondary breast cancer). Materials and Methods: Docetaxel-loaded gelatin nanoparticles using ultraviolet-visible spectroscopy, X-ray diffraction, particle size and size distribution, scanning electron microscopy, drug entrapment efficiency, differential scanning calorimetry, and energy dispersive X-ray were characterized. Results: Solubility, crystallinity, and the crystal properties of an active pharmaceutical ingredient play a critical role in the value chain of pharmaceutical development, manufacturing, and formulation. The rate of drug release for formulation stored at 45 ± 1°C was increased as compared with the fresh formulation; it might be due to the formation of more pores in the nanoparticles due to evaporation of residual amount of solvent. The tissue distribution studies were performed with docetaxel-loaded gelatin nanoparticles after intravenous (IV) injection in Ehrlich ascites tumor-bearing mice. The tissue distribution studies showed a higher concentration of docetaxel-in the tumor as compared with gelatin nanoparticles. The in vivo tumor inhibition study was also performed after IV injection of docetaxel-loaded gelatin nanoparticles up to 15 days. The docetaxel-loaded gelatin nanoparticles reduced tumor volume significantly as compared with plain docetaxel. Our results revealed that docetaxel-loaded gelatin nanoparticles may perhaps maintain the antioxidant levels and reduce the tumor markers thereby exerting chemopreventive potential. Conclusion: These findings support the use of docetaxel-loaded gelatin nanoparticles in target-specific therapy for cancer treatment.

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Section: Discussionmentioning

confidence: 99%

Untitled

Jain¹

2017

IJGP

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“…In emulsion-based vaginal dosage forms several other excipients such as gelling agents, electrolytes, pH regulators, humectants and preservatives (also acting as antiseptics) are frequently employed to modify pharmaceutical properties of the formulation. The addition of gelling polymers, i.e., carbomer, chitosan, hydroxypropyl methyl cellulose (HPMC), methyl cellulose (MC), sodium carboxymethyl cellulose (NaCMC), Pluronic F127, xanthan gum to the aqueous phase increase formulation viscosity enabling for improved stability, emulsion adhesiveness and contact time at the application site [ 76 , 77 , 82 , 84 , 85 , 86 , 89 , 90 , 92 , 93 , 94 , 95 , 98 , 118 , 119 , 120 , 121 , 122 ]. The increased viscosity of the formulation facilitates homogeneous dispersion of the droplets in the continuous phase, limits the mobility of the oil droplets and, as a consequence, prevents flocculation and creaming processes [ 118 , 119 , 120 , 121 , 122 ].…”

Section: Technological Aspects Of Vaginal Formulations Developmentmentioning

confidence: 99%

Emulsion-Based Multicompartment Vaginal Drug Carriers: From Nanoemulsions to Nanoemulgels

Smoleński

Karolewicz

Gołkowska

et al. 2021

IJMS

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In order to overcome the limitations associated with vaginal administration of drugs, e.g., the short contact time of the drug form with the mucosa or continuous carrier wash-out, the development of new carriers for gynecological use is necessary. Furthermore, high individual anatomical and physiological variability resulting in unsatisfactory therapeutic efficacy of lipophilic active substances requires application of multicompartment drug delivery systems. This manuscript provides an up-to-date comprehensive review of the literature on emulsion-based vaginal dosage forms (EVDF) including macroemulsions, microemulsions, nanoemulsions, multiple emulsions and self-emulsifying drug delivery systems. The first part of the paper discusses (i) the influence of anatomical-physiological conditions on therapeutic efficacy of drug forms after local and systemic administration, (ii) characterization of EVDF components and the manufacturing techniques of these dosage forms and (iii) methods used to evaluate the physicochemical and pharmaceutical properties of emulsion-based vaginal dosage forms. The second part of the paper presents (iv) the results of biological and in vivo studies as well as (v) clinical evaluation of EVDF safety and therapeutic efficacy across different indications.

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“…A literature review revealed some findings regarding poloxamer 407-based pharmaceutical emulsions. However, they mainly covered the use of P407 as a secondary excipient [ 18 , 19 ] or when used amongst many other ingredients in micro- or nanoemulsions [ 20 , 21 , 22 , 23 , 24 ], with only rare examples when the thermo–gelation phenomenon was addressed [ 25 , 26 , 27 , 28 , 29 ], although still with the presence of other emulsifiers.…”

Section: Introductionmentioning

confidence: 99%

Poloxamer 407-Based Thermosensitive Emulgel as a Novel Formulation Providing a Controlled Release of Oil-Soluble Pharmaceuticals—Ibuprofen Case Study

2021

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This article covers the design and evaluation of a novel drug vehicle: a thermosensitive, injectable, high-oil-content (50% w/w) emulgel providing a controlled release of lipophilic pharmaceuticals. Different vegetable (castor, canola, olive, peanut, grapeseed, linseed), mineral (paraffin) and semisynthetic (isopropyl myristate, oleic acid) oils were screened for ibuprofen (IBU) solubility and for their capacity for high-shear emulsification in a 17% (w/w) aqueous solution of poloxamer 407. Chosen emulgels were subject to a rheological evaluation, a syringeability test (TA.XT texture analyser; 2 mL syringe; 18 G, 20 G and 22 G needles) and a drug release study (48 h; cellulose membrane; 0.05 mol/L phosphate buffer at pH 7.4). Castor oil turned out to be an optimal component for IBU incorporation. Blank and drug-loaded castor oil emulgels were susceptible to administration via a syringe and needle, with the absolute injection force not exceeding 3 kg (29.4 N). The drug release test revealed dose-dependent, quasi-linear kinetics, with up to 44 h of controlled, steady, linear release. The results indicate the significant potential of high-oil-content, oil-in-water thermosensitive emulgel formulations as vehicles for the controlled release of lipophilic APIs.

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Influence of hydroxypropyl methylcellulose, methylcellulose, gelatin, poloxamer 407 and poloxamer 188 on the formation and stability of soybean oil-in-water emulsions

Cited by 30 publications

References 42 publications

Untitled

Untitled

Emulsion-Based Multicompartment Vaginal Drug Carriers: From Nanoemulsions to Nanoemulgels

Poloxamer 407-Based Thermosensitive Emulgel as a Novel Formulation Providing a Controlled Release of Oil-Soluble Pharmaceuticals—Ibuprofen Case Study

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