Influence of hydroxyl group for thermoresponsive poly(N-isopropylacrylamide) gel particles in water/co-solvent (1,3-propanediol, glycerol) systems

Kim, Sung Min; Lee, Sangmin; Bae, Young Chan

doi:10.1016/j.eurpolymj.2014.03.008

Cited by 10 publications

(4 citation statements)

References 67 publications

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“…Previous studies revealed that the C=O group show a redshift in CP systems from a dry to a hydrated state, leading to a discrepancy in the interaction between drugs and CP in the two systems. The presence of water reduces the ionic interaction force and increases the H-bonding between the drug and polymers [31,32]. In this work, Van der Waals forces were the dominating forces that controlled the drug release; therefore, dry CP is suitable as an alternative to hydrated CP to measure the interaction in different hydrogel systems.…”

Section: Discussionmentioning

confidence: 88%

Quantitative Structure-Activity Relationship of Enhancers of Licochalcone A and Glabridin Release and Permeation Enhancement from Carbomer Hydrogel

et al. 2022

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This study aimed to systematically compare licochalcone A (LicA) and glabridin (Gla) (whitening agents) release and permeation from Carbomer 940 (CP) hydrogels with different enhancers, and evaluate the relationship between the quantitative enhancement efficacy and structures of the enhancers. An in vitro release study and an in vitro permeation experiment in solution and hydrogels using porcine skin were performed. We found that the Gla–CP hydrogel showed a higher drug release and skin retention amount than LicA–CP due to the higher solubility in medium and better miscibility with the skin of Gla than that of LicA. Enhancers with a higher molecular weight (MW) and lower polarizability showed a higher release enhancement effect (ERrelease) for both LicA and Gla. The Van der Waals forces in the drug–enhancers–CP system were negatively correlated with the drug release percent. Moreover, enhancers with a higher log P and polarizability displayed a higher retention enhancement effect in solution (ERsolution retention) for LicA and Gla. Enhancers decreased the whole intermolecular forces indrug–enhancers-skin system, which had a linear inhibitory effect on the drug retention. Moreover, C=O of ceramide acted asthe enhancement site for drug permeation. Consequently, Transcutol® P (TP) and propylene glycol (PG), seven enhancers showed a higher retention enhancement effect in hydrogel (ERhydrogel retention) for LicA and Gla. Taken together, the conclusions provide a strategy for reasonable utilization of enhancers and formulation optimization in topical hydrogel whitening.

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Section: Discussionmentioning

confidence: 88%

Quantitative Structure-Activity Relationship of Enhancers of Licochalcone A and Glabridin Release and Permeation Enhancement from Carbomer Hydrogel

et al. 2022

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“…In the series of alcohols, only glycerol displays a perfect mixing. It is remarkable that the effective Flory parameter for glycerol and water is negative at all concentrations, but glycerol is a poor solvent for PNiPAAm, and does not lead to a co-nonsolvency transition of PNiPAAm in glycerol–water mixtures. We can thus state that an increasing demixing tendency between alcohol and water is correlated with an enhancement of the co-nonsolvency transition of PNiPAAm.…”

Section: Resultsmentioning

confidence: 98%

Co-Nonsolvency Transition of Poly(N-isopropylacrylamide) Brushes in a Series of Binary Mixtures

et al. 2019

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Co-nonsolvency occurs if a mixture of two good solvents causes the collapse or demixing of polymers into a polymer-rich phase in a certain range of compositions of these two solvents. In this work, we systematically study the co-nonsolvency behavior of poly(N-isopropylacrylamide) brushes of different grafting densities in a series of alcohol–water binary mixtures with increasing hydrophobic parts ranging from methanol to 1-butanol by using ellipsometry. We report a strong collapse transition by increasing the alcohol concentration in the water-rich phase, which is enhanced for longer-chain alcohols. The analysis of the thermodynamic properties of the alcohol–water series displays that an increasing demixing tendency between alcohol and water is correlated with an enhancement of the collapse transition of the brush. The increase of grafting density weakens the transition behavior but does not shift the solvent composition point of maximum brush collapse, which is in agreement with the predictions of a recently proposed mean-field model based on the preferential adsorption concept. Among the fully miscible solvents, the most sensitive switching behavior of the brush is found for 1-propanol while 1-butanol already displays a miscibility gap at higher volume fractions.

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“…Stimuli-responsive hydrogels represent a material class, which responds to changes in environmental conditions such as temperature, pH, or substance concentrations in the medium. − During this response, the hydrogels undergo a phase transition triggered by the shifts in thermodynamic equilibrium causing the gel to either imbibe the surrounding liquid through increased affinity or to release it due to lowered affinity. This phenomenon has been utilized for different applications, for example, drug delivery, catalysis, sensor systems, and actuators, , in which use has been made of the control of the gel matrix accessibility and/or the bulk gel volume. ,, This reversible transition of such actuators can also be triggered through the progression of a reaction or deviations in process operation, thereby allowing for reaction-triggered self-regulating reactor concepts.…”

Section: Introductionmentioning

confidence: 99%

Smart Structures—Additive Manufacturing of Stimuli-Responsive Hydrogels for Adaptive Packings

Spille

Schlüter

et al. 2020

Ind. Eng. Chem. Res.

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Smart materials possess a high potential for application in process engineering. Among these smart materials, stimuli-responsive hydrogels exhibit the chemically inherent characteristic to significantly change their macroscopic properties through shifts in environmental conditions. This enables response-triggered actuation caused by a reaction or process deviation. Thereby, smart process concepts are facilitated, which are capable of self-contained process control without external input. Through additive manufacturing of responsive hydrogels, intricate geometries can be generated, with which the response-triggered actuation can perform sophisticated control tasks. Periodic open-cell structures are such geometries, which improve the mass transport in multiphase flows through the distribution of the disperse phase. Responsive hydrogels fabricated as periodic open-cell structures enable the actuation of multiphase flows through an environmental switch allowing for adjustment of flow conditions. Herein, we demonstrate the application of switchable smart structures that facilitate the adaptation of fluid-dynamic properties and mass transfer in cocurrent gas–liquid flows depending on environmental conditions. Smart structures, which are additively manufactured from acrylate photoresist formulations, are applied for in situ and in operandi adjustment of phase distribution through expansion and collapse of these structures in flow channels. Further, diverse photoresist formulations with different associated response triggers are shown, which demonstrate the versatility for application as an in situ and in operandi switch for mass transfer in process units operating with multiphase flows.

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Influence of hydroxyl group for thermoresponsive poly(N-isopropylacrylamide) gel particles in water/co-solvent (1,3-propanediol, glycerol) systems

Cited by 10 publications

References 67 publications

Quantitative Structure-Activity Relationship of Enhancers of Licochalcone A and Glabridin Release and Permeation Enhancement from Carbomer Hydrogel

Quantitative Structure-Activity Relationship of Enhancers of Licochalcone A and Glabridin Release and Permeation Enhancement from Carbomer Hydrogel

Co-Nonsolvency Transition of Poly(N-isopropylacrylamide) Brushes in a Series of Binary Mixtures

Smart Structures—Additive Manufacturing of Stimuli-Responsive Hydrogels for Adaptive Packings

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