Influence of hydroxyethyl starch on lipopolysaccharide‐induced tissue nuclear factor kappa B activation and systemic TNF‐α expression

Abstract

Lower doses of HES may inhibit tissue NF-kappaB activation and systemic TNF-alpha elevation after LPS challenge, which might be helpful during sepsis.

Infusion of hypertonic saline/starch during cardiopulmonary bypass reduces fluid overload and may impact cardiac function

“…Hydroxyethyl starch seems to exert beneficial anti-inflammatory effects (Handrigan et al 2005;Boldt 2006;Gurfinkel et al 2003), and to inhibit cytokines in experimental sepis (Tian et al 2005). The use of hypertonic saline has also been shown to reduce systemic and pulmonary inflammatory responses (reduced levels of TNF-Į and IL-6) ( Gurfinkel et al 2003).…”

Influence of hydroxyethyl starch 130/0.4 in pulmonary neutrophil recruitment and acute lung injury during polymicrobial sepsis in rats

“…Current medium‐molecular‐weight HES solutions seem to be more efficacious. Previous studies in our laboratory have indicated that low doses of HES 200/0.5 can downregulate inflammatory mediators during endotoxemia (4, 5). Recently, HES 130/0.4, a new HES solution, has been developed.…”

Effects of synthetic colloids on oxidative stress and inflammatory response in hemorrhagic shock: comparison of hydroxyethyl starch 130/0.4, hydroxyethyl starch 200/0.5, and succinylated gelatin

“…demonstrated that a lower dose of HES 200 (3.75 and 7.5 mL/kg) significantly suppresses LPS-induced NF-κB activation in four tissues (lungs, liver, heart, and kidneys). However, 15 mL/kg HES 200 inhibits NF-κB activity only in the lungs and liver, and 30 mL/kg HES 200 exerts no effect in any measured organs [35,37]. The effect of GEL on the inflammatory response was similar at three doses (7.5, 15 and 30 mL/kg) [38].…”