Influence of Hydrothermal Treatment on Physicochemical Properties and Drug Release of Anti-Inflammatory Drugs of Intercalated Layered Double Hydroxide Nanoparticles

Abstract

The synthesis method of layered double hydroxides (LDHs) determines nanoparticles’ performance in biomedical applications. In this study, hydrothermal treatment as an important synthesis technique has been examined for its influence on the physicochemical properties and the drug release rate from drug-containing LDHs. We synthesised MgAl–LDHs intercalated with non-steroidal anti-inflammatory drugs (i.e., naproxen, diclofenac and ibuprofen) using a co-precipitation method with or without hydrothermal treatment (150 °C, 4 h). After being hydrothermally treated, LDH–drug crystallites increased in particle size and crystallinity, but did not change in the interlayer anion orientation, gallery height and chemical composition. The drug release patterns of all studied LDH–drug hybrids were biphasic and sustained. LDHs loaded with diclofenac had a quicker drug release rate compared with those with naproxen and ibuprofen, and the drug release from the hydrothermally-treated LDH–drug was slower than the freshly precipitated LDH–drug. These results suggest that the drug release of LDH–drugs is influenced by the crystallite size of LDHs, which can be controlled by hydrothermal treatment, as well as by the drug molecular physicochemical properties.

Layered gadolinium hydroxides for simultaneous drug delivery and imaging

“…62 The similarity of the spectra of the intercalates and drug salts confirms successful intercalation. Scanning electron microscopy (SEM) images of the LGdH particles are presented in Fig.…”

Multi-laminated metal hydroxide nanocontainers for oral-specific delivery for bioavailability improvement and treatment of inflammatory paw edema in mice

“…S1. The diameters of the Eudragit polymer coated samples increased substantially and are all in the range of 300-400 nm due to particle agglomeration during measurement and coating, which resulted in a slight increase in the hydrodynamic size of the particle [52]. Respective polydispersity index (PDI) values of all of the samples are provided in Table S1.…”

“…The unique ion-layer charge interaction in the supermolecular structure allow for the intercalation of various anionic molecules and fluorescent dyes via ion-exchange to construct a variety of LDH nanohybrids that have desirable properties for various uses, such as drug delivery [32][33][34][35][36], vaccination [37], targeting [38], and imaging [39,40]. LDHs have been used as a carrier for various negatively charged bio-moieties, for instance siRNA [31,[41][42][43][44][45][46], antibodies [2], carbohydrates [47], amino acids [48], enzymes [49], antimicrobial drugs [50,51], anti-inflammatory drugs [52], and anticancer drugs [33,36,[53][54][55][56][57][58]. In addition, LDHs possess beneficial properties, such as high surface area, high dispersity, high anionic drug loading ability and good biocompatibility [59,60] with controlled drug release [26,36,40,55,[61][62][63][64][65][66].…”

Ammonium alcohol polyvinyl phosphate intercalated LDHs/epoxy nanocomposites

“…For example, 3126 and 1409 cm -1 of AAPP and 1115 cm -1 of LDHs shift to 3112, 1403 and 1109 cm -1 , respectively, after intercalation to LDHs. The FTIR analysis shows good interaction between the AAPP and the LDHs [20,21]. Figure 4 presents the EDS pattern and elemental composition (inset) of ILDHs.…”