Influence of hydration on renal function and medullary sodium during vasopressin infusion

Perlmutt, Joseph H.

doi:10.1152/ajplegacy.1962.202.6.1098

Cited by 25 publications

(13 citation statements)

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“…min was adequate to prevent the appearance of a water diuresis in a conscious dog. However, it is apparent that in anaesthetized dogs the effectiveness of vasopressin in concentrating the urine is dependent upon the osmolal clearance (Orloff, Wagner & Davidson, 1957) and upon the state of hydration of the animal (Perlmutt, 1962). Recent experiments (Mason & Ledsome, 1971) Fig.…”

Section: Resultsmentioning

confidence: 99%

The effects of vasopressin on the diuretic response to left atrial distension

Ledsome¹,

Mason²

1972

The Journal of Physiology

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4. During infusion of vasopressin in doses of 04 m-u./kg. min and 1.0 m-u./kg. min changes in free water clearance were dependent upon changes in osmolal clearance indicating that these doses of vasopressin provided a maximum antidiuretic effect.5. Infusion of vasopressin had no effect on the increase in osmolal clearance which occurred in response to left atrial distension.6. The results allow the view that a part of the diuretic response to left atrial distension could depend upon a decrease in the concentration of antidiuretic hormone in the circulating blood.

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Section: Resultsmentioning

confidence: 99%

The effects of vasopressin on the diuretic response to left atrial distension

Ledsome¹,

Mason²

1972

The Journal of Physiology

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“…Levitin and associates (2), and Perlmutt (4) obtained their data on dogs during acute water diuresis and within 2 hours after beginning an infusion of vasopressin. Their conclusion seems correct, therefore, that the observed differences in sodium content of medulla and papilla resulted from differences in medullary blood flow.…”

Section: Resultsmentioning

confidence: 99%

“…In contrast, Jaenike has pre-sented indirect evidence suggesting that vasopressin does not enhance the medullary sequestration of nonurea solute (3). Although other investigators have reported similar studies (4,5), there still is no agreement whether or not vasopressin promotes the medullary sequestration of sodium. The availability of rats with a genetic, apparently absolute, defect for synthesizing vasopressin (6) seemed to present an ideal opportunity for reinvestigating this problem.…”

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confidence: 99%

Sequestration of urea and nonurea solutes in renal tissues of rats with hereditary hypothalamic diabetes insipidus: effect of vasopressin and dehydration on the countercurrent mechanism.

Valtin¹

1966

J. Clin. Invest.

130

100

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This study was prompted by three problems: 1) the role of vasopressin in the countercurrent mechanism for concentrating urine; 2) the effect of dehydration on this mechanism; and 3) the behavior of this mechanism in the absence of vasopressin when the body fluid volumes are contracted rather than expanded.Although it is generally accepted that countercurrent systems in the renal medulla effect the concentration of urine, several questions about the operation of these systems remain unanswered (1). For example, it is not known whether vasopression enhances the sequestration of nonurea solutes in the medullary interstitium, either by increasing the reabsorption of sodium from the loops of Henle, by slowing medullary blood flow, or both. Levitin, Goodman, Pigeon, and Epstein demonstrated a progressive and significant increase in sequestered sodium within the renal papilla and medulla of dogs as vasopressin was superimposed on a water diuresis by intravenous infusion (2). Since they also found the enrichment of papillary and medullary sodium by infused 22Na to be more rapid during water diuresis than during antidiuresis, they suggested that vasopressin may promote medullary sequestration of sodium by slowing medullary blood flow, not by increasing reabsorption of sodium from the ascending loops of Henle. In contrast, Jaenike has pre-

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“…Numerous investigators have observed that the increase in medullary solute concentration seen in antidiuresis as compared with water diuresis, is a consequence of an increased solute content as well as a reduced water content (2,3,(17)(18)(19)(20)(21). By using graded doses of lysine-vasopressin, Atherton et al (3) further observed that the reduction in free water clearance occurred at a lower dose ofthe hormone than that required to increase medullary solute content.…”

Section: Discussionmentioning

confidence: 99%

Effect of vasopressin on electrical potential difference and chloride transport in mouse medullary thick ascending limb of Henle's loop.

Hall¹,

Varney²

1980

J. Clin. Invest.

164

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A B S T R A C T Medullary thick ascending limbs ofHenle's loop of the Swiss-Webster mouse were perfused in vitro with an isotonic perfusate and a Ringer's bathing medium. In five studies, addition of a supramaximal concentration of synthetic arginine vasopressin (AVP) to the bathing medium resulted in an increase in electrical potential difference (PD) from 5.0±1.5 mV, lumen positive, to 10.7±1.4 mV (P < 0.001). When AVP was removed, the PD returned to 2.6±0.9 mV (P < 0.001), then increased again to 6.9±1.7 mV (P < 0.01) when AVP was added a second time. A significant, but submaximal, increase in PD of 2.3±0.6 mV (P < 0.05) was observed in five medullary thick ascending limbs when AVP was added to the bathing medium at a concentration of 10 AU/ml. This increase was approximately one-third of the response observed at a concentration of 100 ,uU/ml in the same tubule. No further increment in PD was observed in five medullary thick ascending limbs when the AVP concentration was increased from 100 to 1,000 ,uU/ml. In seven thick ascending limbs, the effect of AVP on PD was reproduced by the addition of 8-[p-chlorophenylthio]-cyclic 3',5'-adenosine monophosphate to the bathing medium at a final concentration of 0.1 mM. AVP increased unidirectional chloride flux from lumen to bath from 29.3±3.2 to 69.8±6.2 peq/cm per s (P < 0.01) in spite of an increase in the lumen positive PD from 1.6±0.5 mV to 7.0+0.6 mV (P < 0.001). Unidirectional chloride flux from bath to lumen was not affected by AVP. In another series of experiments, net chloride flux increased from 15.6±3.0 to 41.7±5.3 peq/cm per s (P < 0.05) after addition of AVP. The effect of AVP on hydraulic water pertneability (Lp) was examined by adding raffinose to the bathing medium in both the

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Influence of hydration on renal function and medullary sodium during vasopressin infusion

Cited by 25 publications

References 0 publications

The effects of vasopressin on the diuretic response to left atrial distension

The effects of vasopressin on the diuretic response to left atrial distension

Sequestration of urea and nonurea solutes in renal tissues of rats with hereditary hypothalamic diabetes insipidus: effect of vasopressin and dehydration on the countercurrent mechanism.

Effect of vasopressin on electrical potential difference and chloride transport in mouse medullary thick ascending limb of Henle's loop.

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