Influence of Hybrid Surface Modification on Biocompatibility and Physicochemical Properties of Ti-6Al-4V ELI Titanium

Abstract

Titanium-based materials are the most widely used materials in biomedical applications. However, according to literature findings, the degradation products of titanium have been associated with potential allergic reactions, inflammation, and bone resorption. The corrosion process of Ti-6Al-4V in the human body environment may be exacerbated by factors such as reduced pH levels and elevated concentrations of chloride compounds. Coatings made of biopolymers are gaining attention as they offer numerous advantages for enhancing implant functionality, including improved biocompatibility, bioactivity, wettability, drug release, and antibacterial activity. This study analyzes the physicochemical and electrochemical behavior of the Ti-6Al-4V ELI alloy subjected to PCL and PCL/TiO2 deposition by the electrospinning method. To characterize the polymer-based layer, tests of chemical and phase composition, as well as surface morphology investigations, were performed. Wetting angle tests were conducted as part of assessing the physicochemical properties. The samples were subjected to corrosion behavior analysis, which included open circuit potential measurements, potentiodynamic tests, and the electrochemical impedance spectroscopy method. Additionally, the quantification of released ions post the potentiodynamic test was carried out using the inductively coupled plasma atomic emission spectrometry (ICP–AES) method. Cytotoxicity tests were also performed. It was found that surface modification by depositing a polymer-based layer on the titanium substrate material using the electrospinning method provides improved corrosion behavior, and the samples exhibit non-toxic properties.

The Development of a 3D PET Fibrous Scaffold Modified with an Umbilical Cord dECM for Liver Tissue Engineering

“…In stark contrast, the untreated PET fibers only hosted a scant number of cells. Hydrophilicity stands as a pivotal criterion in evaluating a material's biocompatibility, and our observations may be attributed to the material's hydrophilic properties [46,47]. The PET-dECM, adorned with a dECM coating, showcases remarkable biocompatibility, fostering a conducive environment for cell growth and bolstering cell adhesion and proliferation.…”