Influence of human nail etching for the assessment of topical onychomycosis therapies

Development of terbinafine solid lipid nanoparticles as a topical delivery system

“…The possible reason is that the highest solubility of TB is at pH 3, and the pH value of formulation CPbI was 2.7, so some portion of the drug might have penetrated into the water phase instead of the lipid phase, thus decreasing the amount of TB available for penetration. This result does not seem to be consistent with that reported by Repka et al 28 and Vaka et al, 29 the former of which conducted in vitro permeability studies by applying ketoconazole to human nail samples treated with an etching agent (10% phosphoric acid gel) and demonstrated a significant increase in drug permeability compared to a control (unetched nail samples).…”

Bilayered Nail Lacquer of Terbinafine Hydrochloride for Treatment of Onychomycosis

“…13 The adhesion of HPMC lacquer films to the cadaver nails was determined using Texture Analyzer 1 equipped with a 50-kg load cell (TA.XT2i, Technologies Corp., Scarsdale, NY/ Stable Micro Systems, Godalming, Surrey, UK) ( Fig. 1).…”

Investigation of different formulations for drug delivery through the nail plate

“…Griseofulvin, which was the first oral antifungal drug approved by the US Food and Drug Administration or ketoconalzole from the Azole group are currently not used much (Gupta and Tu, 2006;Gauwerky et al, 2009). However, oral systemic antifungal therapy is limited by its toxicity, drug interactions, contraindications, high cost of medication, increased microbe resistance, a long duration of treatment, and relapse is very common (Murdan, 2002;Repka et al, 2004). Topical therapies, on the other hand, have difficulties, too.…”