Influence of Human Milk and Parenteral Lipid Emulsions on Serum Fatty Acid Profiles in Extremely Preterm Infants

Nilsson, Anders; Löfqvist, Chatarina; Najm, Svetlana; Hellgren, Gunnel; Sävman, Karin; Andersson, Mats X.; Smith, Lois E H; Hellström, Ann

doi:10.1002/jpen.1172

Cited by 11 publications

(8 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Further, the proportion of PC containing linoleic acid increased throughout the study period. This also corroborates our previous findings on the phospholipid fatty acid profiles in these preterm infants [ 30 ] and reflects the high nutritional intake of linoleic acid during the neonatal period [ 31 ]. As expected, the PC species composition changes largely follow that of total phospholipid-bound fatty acids, as PC constitutes the major phospholipid class in serum.…”

Section: Discussionsupporting

confidence: 92%

Sphingolipidomics of serum in extremely preterm infants: Association between low sphingosine-1-phosphate levels and severe retinopathy of prematurity

Nilsson

Andersson

Sjöbom

et al. 2021

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biolog

Self Cite

View full text Add to dashboard Cite

Background: Extremely preterm infants are at risk of developing retinopathy of prematurity (ROP) that can cause impaired vision or blindness. Changes in blood lipids have been associated with ROP. This study aimed to monitor longitudinal changes in the serum sphingolipidome of extremely preterm infants and investigate the relationship to development of severe ROP. Methods: This is a prospective study that included 47 infants born <28 gestational weeks. Serum samples were collected from cord blood and at postnatal days 1, 7, 14, and 28, and at postmenstrual weeks (PMW) 32, 36, and 40. Serum sphingolipids and phosphatidylcholines were extracted and analyzed by LC-MS/MS. Associations between sphingolipid species and ROP were assessed using mixed models for repeated measures. Results: The serum concentration of all investigated lipid classes, including ceramide, mono- di- and trihexosylceramide, sphingomyelin, and phosphatidylcholine displayed distinct temporal patterns between birth and PMW40. There were also substantial changes in the lipid species composition within each class. Among the analyzed sphingolipid species, sphingosine-1-phosphate showed the strongest association with severe ROP, and this association was independent of gestational age at birth and weight standard deviation score change. Conclusions: The serum phospho- and sphingolipidome undergoes significant remodeling during the first weeks of the preterm infant’s life. Low postnatal levels of the signaling lipid sphingosine-1-phosphate are associated with the development of severe ROP.

show abstract

Section: Discussionsupporting

confidence: 92%

Sphingolipidomics of serum in extremely preterm infants: Association between low sphingosine-1-phosphate levels and severe retinopathy of prematurity

Nilsson

Andersson

Sjöbom

et al. 2021

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biolog

Self Cite

View full text Add to dashboard Cite

show abstract

“…In our previous study, Intralipid was shown to contain higher amounts of LA derived oxylipins compared to SMOFlipid® [27]. It is therefore likely that differences in the peak levels of LA derived oxylipins between the groups are due to the LA derived oxylipins that are administered with the lipid emulsions.…”

Section: Discussionmentioning

confidence: 93%

Intravenous fat induces changes in PUFA and their bioactive metabolites: Comparison between Japanese and Australian preterm infants

Suganuma

McPhee

Collins

et al. 2020

Prostaglandins, Leukotrienes and Essential Fatty Acids

View full text Add to dashboard Cite

Oxylipins are biologically active signaling molecules that initiate and resolve inflammation; they are synthesized by oxidation of polyunsaturated fatty acids (PUFAs) and reflect PUFA intake and status. The PUFA intake in preterm infants differs between countries because of the type of lipid emulsions used and the PUFA content of breast milk. We compared total blood PUFA, free PUFA and their oxylipin levels in dried whole blood samples from preterm infants born in Australia and Japan. Methods: We enrolled 30 and 14 preterm infants born less than 31 weeks' gestation, from Adelaide and Japan respectively. Blood samples were obtained from cord blood, and on postnatal days 4, 7, 14 and 28. Total PUFAs were measured using gas chromatography, while free fatty acids and oxylipins were screened using ultra highperformance liquid chromatography mass spectroscopy. Results: Differences in the levels of blood PUFA between the centres were found which were in line with the timing and type of lipid emulsion administration. Significant differences in longitudinal levels were seen more often in free PUFA and their oxylipins than in total blood PUFA. This was particularly true for AA and DHA. In contrast, differences in the levels could be seen in total blood EPA, as well as in free EPA and its oxylipins. Further, levels of many free PUFA and their oxylipins were higher in Japanese infants than in Australian infants. Conclusion: Differences in total and free fatty acids and unesterified oxylipins, were observed during the first weeks of life and between preterm infants born in Australia and Japan, which were likely a reflection of the type of lipid emulsion and timing of administration. The clinical significance of these changes remains to be explored. including the omega-6 linoleic acid (LA) and the omega-3 alpha linolenic acid (ALA), as well as their long chain PUFA metabolites arachidonic acid (AA-an omega-6 derivative), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), both omega-3 derivatives. The majority of fats in the circulation, whether derived from tissue sources, the diet or administered intravenously, exist esterified into triglycerides, phospholipids or cholesteryl esters. In response to various

show abstract

“…Fetal levels of DHA and AA are affected by maternal dietary intake, enzymatic activity regulating fatty acid metabolism, and placental transport [ 42 ]. After birth, infant levels are affected by the composition of omega-6 and omega-3 fatty acids in parenteral and enteral supply [ 43 , 44 ]. Recent recommendations state that AA should be provided to preterm infants along DHA [ 45 ].…”

Section: Discussionmentioning

confidence: 99%

Docosahexaenoic Acid and Arachidonic Acid Levels Are Associated with Early Systemic Inflammation in Extremely Preterm Infants

Hellström

Hellgren

et al. 2020

Nutrients

Self Cite

View full text Add to dashboard Cite

Fetal and early postnatal inflammation have been associated with increased morbidity in extremely preterm infants. This study aimed to demonstrate if postpartum levels of docosahexaenoic acid (DHA) and arachidonic acid (AA) were associated with early inflammation. In a cohort of 90 extremely preterm infants, DHA and AA in cord blood, on the first postnatal day and on postnatal day 7 were examined in relation to early systemic inflammation, defined as elevated C-reactive protein (CRP) and/or interleukin-6 (IL-6) within 72 h from birth, with or without positive blood culture. Median serum level of DHA was 0.5 mol% (95% CI (confidence interval) 0.2–0.9, P = 0.006) lower than the first postnatal day in infants with early systemic inflammation, compared to infants without signs of inflammation, whereas levels of AA were not statistically different between infants with and without signs of inflammation. In cord blood, lower serum levels of both DHA (correlation coefficient −0.40; P = 0.010) and AA (correlation coefficient −0.54; p < 0.001) correlated with higher levels of IL-6. Levels of DHA or AA did not differ between infants with and without histological signs of chorioamnionitis or fetal inflammation. In conclusion, serum levels of DHA at birth were associated with the inflammatory response during the early postnatal period in extremely preterm infants.

show abstract

Influence of Human Milk and Parenteral Lipid Emulsions on Serum Fatty Acid Profiles in Extremely Preterm Infants

Cited by 11 publications

References 40 publications

Sphingolipidomics of serum in extremely preterm infants: Association between low sphingosine-1-phosphate levels and severe retinopathy of prematurity

Sphingolipidomics of serum in extremely preterm infants: Association between low sphingosine-1-phosphate levels and severe retinopathy of prematurity

Intravenous fat induces changes in PUFA and their bioactive metabolites: Comparison between Japanese and Australian preterm infants

Docosahexaenoic Acid and Arachidonic Acid Levels Are Associated with Early Systemic Inflammation in Extremely Preterm Infants

Contact Info

Product

Resources

About