Influence of human immunodeficiency virus type 1 infection on the natural course of chronic parenterally acquired Hepatitis C

Sánchez-Quijano, A; Andreu, J.L.; Gavilán, Francisco Socas; Luque, Francisco; Abad, M. A.; Soto, B.; Muñoz, Josefa; Aznar, Julia Mesa; Leal, Manuel; Lissén, E

doi:10.1007/bf01691375

Cited by 143 publications

(80 citation statements)

References 14 publications

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“…Some studies have associated HCV coinfection with a faster HIV progression, although this conection is controversial 5,18,[21][22][23]30 . HCV infection also increases the toxicity to antiretroviral medications 9,18,26,27,32 .…”

Section: Introductionmentioning

confidence: 99%

Serological markers and risk factors for hepatitis B and C viruses in patients infected with human immunodeficiency virus

Hoyos-Orrego

Massaro-Ceballos

Ospina-Ospina

et al. 2006

Rev. Inst. Med. trop. S. Paulo

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SUMMARYBoth hepatitis B and hepatitis C viruses (HBV and HCV) infection are common in HIV-infected individuals as a result of shared risk factors for acquisition. A serological study for HBV and HCV was performed in 251 HIV-positive individuals from Medellín, Colombia. A qualitative RT-PCR for HCV was done in 90 patients with CD4+ T-cell count ≤ 150 per mm 3 . Serological markers for HBV infection were present in 97 (38.6%) patients. Thirty six of them (37.1%) had isolated anti-HBc. A multivariate analysis indicated that the following risk factors were significantly associated with the presence of these markers: age (OR = 1.05, 95% CI: 1.01-1.08), pediculosis pubis (OR = 1.83, 95% CI: 1.01-3.33), men who have sex with men and women (OR = 3.23, 95% CI: 1.46-7.13) and men who have sex only with men (OR = 3.73, 95% CI: 1.58-8.78). The same analysis restricted to women showed syphilis as the only significant risk factor. Thus, HBV infection was considerably associated with high risk sexual behavior. HCV was present in only two (0.8%) of HIV patients. Both of them were positive by RT-PCR and anti-HCV. This low frequency of HIV/HCV coinfection was probably due to the uncommon intravenous drug abuse in this population. The frequent finding of isolated anti-HBc warrants molecular approaches to rule out the presence of cryptic HBV infection.

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Section: Introductionmentioning

confidence: 99%

Serological markers and risk factors for hepatitis B and C viruses in patients infected with human immunodeficiency virus

Hoyos-Orrego

Massaro-Ceballos

Ospina-Ospina

et al. 2006

Rev. Inst. Med. trop. S. Paulo

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“…[7][8][9] Several factors such as alcohol abuse, coinfection with HBV or HIV, gender or age at infection determine the highly variable course of liver disease in hepatitis C virus (HCV) infection. 5,[10][11][12] Besides, the hepatocellular injury in patients with CHC results from the host's immunemediated responses to viral infection. In this respect, the host's immunogenetic make-up plays an important role in determining the natural history of CHC.…”

Section: Introductionmentioning

confidence: 99%

Bi-allelic presence of the interleukin-10 receptor 1 G330R allele is associated with cirrhosis in chronic HCV-1 infection

et al. 2005

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Immune response to viral infection is an important determinant of liver injury in chronic hepatitis C (CHC). Experimental and clinical data suggest a protective role of interleukin-10 (IL-10) in hepatic fibrogenesis. The significance of two SNPs of the interleukin-10 receptor 1 (IL-10R1), S138G (SNP3) and G330R (SNP4) was investigated on (i) susceptibility to CHC, (ii) progression of hepatic fibrosis and (iii) response to interferon/ribavirin therapy. DNA and liver biopsies were obtained from 212 patients with HCV (hepatitis C virus)-genotype-1 infection. The allele frequencies were 0.17 for SNP3 and 0.33 for SNP4, both of which were indifferent from healthy controls (0.17 and 0.32, respectively). Stage 1 liver fibrosis was found in 22 cases (10.4%), stage 2 in 108 (50.9%), stage 3 in 27 (12.8%), and stage 4 (cirrhosis) in 55 (25.9%). An association was found between the SNP4 allele and the presence of cirrhosis (P ¼ 0.01). Homozygous SNP4 individual variants segregated within the cirrhosis group (P ¼ 0.03). We found neither an association with SNP3 nor with the necroinflammatory disease activity (as measured by ALT levels) nor with the response to antiviral therapy. Our work implies that IL-10R1 SNP4 is a recessively inherited risk factor for hepatic cirrhosis in HCV genotype-1 infection.

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“…The livers of coinfected patients have more fibrosis and more severe necroinflammatory changes (1,3,5,14,27). The frequencies of cirrhosis (5,27,32,35) and hepatic decompensation (12,22,29,37) are increased among coinfected patients compared to those among patients infected only with HCV.…”

mentioning

confidence: 99%

“…The course of chronic HCV infection is accelerated in patients coinfected with HIV (12,13,30,32,35,37,41). The livers of coinfected patients have more fibrosis and more severe necroinflammatory changes (1,3,5,14,27).…”

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confidence: 99%

Comparison of Hepatitis C Viral Loads in Patients with or without Human Immunodeficiency Virus

Matthews-Greer

Caldito

Adley

et al. 2001

Clin Diagn Lab Immunol

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A better understanding of how human immunodeficiency virus (HIV) coinfection affects the course of hepatitis C virus (HCV) infection is required to select patients with HIV who would benefit from current HCV therapy. Between June 1996 and March 2000, HCV RNA levels were quantified for 1,279 patients at the Louisiana State University Health Sciences Center; 28 of these patients were coinfected with HIV. HCV loads were quantified by the Bayer branched-DNA assay with a lower limit of detection of 0.2 Meq/ml. We compared the median HCV RNA levels of for patients coinfected with HIV and HCV and patients infected only with HCV who were in the same age range (23 to 55 years). The median HCV load for the 28 patients coinfected with HCV and HIV (17.8 Meq/ml) was significantly greater (P < 0.05) than that for similarly aged patients infected only with HCV (6.1 Meq/ml). The HCV load did not correlate with age or sex for either group of patients. A significant (R ‫؍‬ ؊0.4; P < 0.05) negative correlation was observed between HCV load and CD4 count in the coinfected group, for whom the CD4 counts at the time of HCV load analysis ranged from 6 to 1,773/mm 3 . The increased HCV load in patients coinfected with HCV and HIV compared to that in patients infected only with HCV and the inverse relationship of the HCV load to the CD4 count indicate that immunosuppression results in decreased control of HCV replication. In addition, we report significantly higher HCV loads among coinfected African Americans than Caucasians.

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Influence of human immunodeficiency virus type 1 infection on the natural course of chronic parenterally acquired Hepatitis C

Cited by 143 publications

References 14 publications

Serological markers and risk factors for hepatitis B and C viruses in patients infected with human immunodeficiency virus

Serological markers and risk factors for hepatitis B and C viruses in patients infected with human immunodeficiency virus

Bi-allelic presence of the interleukin-10 receptor 1 G330R allele is associated with cirrhosis in chronic HCV-1 infection

Comparison of Hepatitis C Viral Loads in Patients with or without Human Immunodeficiency Virus

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