Influence of hospitalization and placebo therapy on blood pressure and sympathetic function in essential hypertension.

Hossmann, V.; FitzGerald, Garret A.; Dollery, C T

doi:10.1161/01.hyp.3.1.113

Cited by 60 publications

(32 citation statements)

References 16 publications

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“…The blood pressure of hypertensive patients usually falls after hospital admission, 14 although the mechanism is not fully understood. Restriction of sodium intake to 137-171 meq/day compared with the Japanese average daily sodium intake of 222-256 meq/day and bed rest during hospitalization may be part of the reason for the decline in blood pressure.…”

Section: Discussionmentioning

confidence: 99%

Cerebral blood flow and metabolism in normotensive and hypertensive patients with transient neurologic deficits.

Fujii

Sadoshima

Okada

et al. 1990

Stroke

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We used positron emission tomography to examine retrospectively the effects of blood pressure on regional cerebral blood flow and oxygen metabolism in seven normotensive and eight hypertensive patients with a history of transient neurologic deficits. In the hypertensive patients, a decrease in regional cerebral blood flow was closely related to blood pressure; these changes were most pronounced in the supratentorial structures, especially the striatum and thalamus. In contrast, the regional cerebral metabolic rate for oxygen was less related to blood pressure. Consequently, the regional oxygen extraction fraction was increased in the hypertensive patients, while regional cerebral blood volume and the regional cerebral blood flow: volume ratio were unchanged. Multivariate regression analysis confirmed that hypertension was an independent factor affecting regional cerebral blood flow. The analysis also disclosed that age, sex, hematocrit, smoking, and Paco 2 affected regional cerebral blood flow. These findings suggest that the hemodynamic reserve in hypertensive individuals is reduced, which may predispose them to cerebral ischemia and perhaps stroke, even during small decreases in cerebral perfusion pressure. (Stroke 1990^1:283-290)

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Section: Discussionmentioning

confidence: 99%

Cerebral blood flow and metabolism in normotensive and hypertensive patients with transient neurologic deficits.

Fujii

Sadoshima

Okada

et al. 1990

Stroke

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“…This phenomenon is favored by reduction or suppression of some psychic and physical components (anxiety, working stress, environmental reactions, etc. ), and especially by the knowledge of continuous assistance, vigilance, and readily available aid in any emergency (De Leeuw et al, 1981;Hossman et al, 1981;Moutsos et al, 1967).…”

Section: Introductionmentioning

confidence: 99%

Detection of a diurnal rhythm in arterial blood pressure in the evaluation of 24‐hour antihypertensive therapy

Germanò¹,

Ciavarella²,

Appolloni³

et al. 1984

Clinical Cardiology

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Summary:Uncertainty in defining hypertensive disease makes a prolonged study of blood pressure pattern necessary, using continuous or semicontinuous blood pressure recordings. Its pathophysiological meaning involves data sufficiently indicative of blood pressure profile with reference to the continuous stimulations of different intensity and duration, which are met by subjects both in their daily activities and in the passage from an active life to sleep. Such a parameter is, in fact, an indispensable premise for a correct course of therapy. The aim of our work was at first the detection of a diurnal rhythm in blood pressure, using data obtained in a 24-h ambulatory monitoring away from the conditioning of different activities and daily routine. We have employed three groups of 34 males each. The first group consisted of hypertensive outpatients, while hospitalized subjects comprised the second group. Thethird group was composed of normal subjects. Furthermore, after finding this system productive, we started studying whether this rhythm of blood pressure could be modified under the influence of a single administered drug dose, and whether information obtained could be easily interpreted. We studied 12 male patients with essential hypertension, which had been untreated. Each patient underwent three 24-h blood pressure ambulatory monitorings. Two different doses of nifedipine (10 and 20 mg) were randomly administered to each of the patients at the beginning of the second and third readings. We observed a significant fall in systolic blood pressure and a minor decrease in diastolic blood pressure after administration of a single 10 mg nifedipine tablet.

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“…Individually, this blood pressure elevation is not a matter of using antihypertensive medication 1 . It is also important to observe that hypertensive patients experience a decrease in blood pressure after being admitted to the hospital regardless of the treatment [2][3][4][5] . In the last 2 decades, antihypertensive medications that act quickly after oral or sublingual administration [6][7][8][9][10][11][12] have been used.…”

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confidence: 99%

Use of oral antihypertensive medication preceding blood pressure elevation in hospitalized patients

Macedo¹,

Noblat²,

Noblat³

et al. 2001

Arq. Bras. Cardiol.

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Influence of hospitalization and placebo therapy on blood pressure and sympathetic function in essential hypertension.

Cited by 60 publications

References 16 publications

Cerebral blood flow and metabolism in normotensive and hypertensive patients with transient neurologic deficits.

Cerebral blood flow and metabolism in normotensive and hypertensive patients with transient neurologic deficits.

Detection of a diurnal rhythm in arterial blood pressure in the evaluation of 24‐hour antihypertensive therapy

Use of oral antihypertensive medication preceding blood pressure elevation in hospitalized patients

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