INFLUENCE OF HORMONES ON LYMPHOID TISSUE STRUCTURE AND FUNCTION. THE ROLE OF THE PITUITARY ADRENOTROPHIC HORMONE IN THE REGULATION OF THE LYMPHOCYTES AND OTHER CELLULAR ELEMENTS OF THE BLOOD<sup>1</sup>

Dougherty, Thomas F.; White, Abraham

doi:10.1210/endo-35-1-1

Cited by 246 publications

(22 citation statements)

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“…At times, the numbers of each were higher at 24 hours than at any time previously. This eosinophilia and lymphocytosis may reflect a period of decreased adrenal activity as previously mentioned, or may be the result of increased cell production following their destruction (1). Changes in lymphocytes and eosinophils were well correlated with dosage in the individual who received graded doses of compound F acetate.…”

Section: Discussionsupporting

confidence: 55%

Blood Levels of 17-Hydroxycorticosteroids Following the Administration of Adrenal Steroids and Their Relation to Levels of Circulating Leukocytes 1

Nelson¹,

Sandberg²,

Palmer³

et al. 1952

J. Clin. Invest.

112

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Section: Discussionsupporting

confidence: 55%

Blood Levels of 17-Hydroxycorticosteroids Following the Administration of Adrenal Steroids and Their Relation to Levels of Circulating Leukocytes 1

Nelson¹,

Sandberg²,

Palmer³

et al. 1952

J. Clin. Invest.

112

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“…The initial decline in circulating lymphocytes noted within 1.5 hr after endotoxin infusion was not attributed to the lytic effect known to be produced by corticosteroids ( 12), because significant depressions in circulating lymphocytes occurred 0.5 hr following the noted increase in plasma corticosteroid concentrations ( Table I ) . Most importantly, definitive studies by this ( 1 3 ) and other laboratories (14) clearly indicate that elevated plasma corticosteroid concentrations seen after adrenocorticotropin ( ACTH) stimulation occurs within 15 min following ACTH administration and that significant depressions in the percentage of circulating lymphocytes will not occur until 2 hr post-ACTH injection.…”

mentioning

confidence: 89%

Plasma Corticosteroid, Circulating Leukocyte and Milk Somatic Cell Responses to Escherichia coli Endotoxin-Induced Mastitis

Paape¹,

Schultze²,

Desjardins³

et al. 1974

Experimental Biology and Medicine

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“…Hormonal control is important in the release of these globulins because, following pituitary stimulation or the administration of excess adrenotrophin or adrenal cortical preparations, lymphocytes are dissolved in lymphoid tissues and shed their cytoplasm, i.e. , release globulin, to the extent that a marked lymphopenia and an increase in serum ,8-and 'Y-globulins, but not of a-globulin, occurs in the blood (214,215,216). The availability of these proteins during stress is probably contingent on the presence of the pituitary and adrenals, because lymphoid tissue does not show these changes and reserve lymphocyte protein is not released in adrenalectomized animals during a period of fast.…”

Section: Hormonal Control Of Antibody Releasementioning

confidence: 99%

The Cellular Basis of Immunity

Taliaferro¹

1949

Annu. Rev. Microbiol.

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Once invading organisms or other antigenic materials have passed or have been introduced beyond the epithelial or mechani cal barriers, their localization and disposal is a part of local (local inflammation) and general defense reactions. The main functional roles of the cells involved in these reactions are (a) to remove foreign material by extra-or intracellular digestion (phagocytosis) or to isolate it by a connective tissue wall (encapsulation); (b) to perform various reparative processes; and (c) to produce specific antibodies. With the exception of that part of repair which involves the parenchyma, the cells involved belong almost exclusively to the connective tissue, especially to the blood and lymph, to the reticular and loose connective tissues, and to the lamina propria and interstitial connective tissues of various organs including the brain. The cells are important to varying degrees in immunity be cause (a) they are ubiquitous in distribution or are easily mobilized via the blood stream; (b) they are phagocytic and/or possess potent digestive enzymes; and (c) they form a mesenchymal reserve in the postnatal vertebrate by retaining varying degrees of their embryonic power to develop into other cells of the connective tissue. These cells have other functions. As a whole, they take part in such diverse processes as intermediate metabolism, storage and mechanical support. A review of the functions of the reticulo endothelial system is given by Jaffe (1) and of the leucocytes by Rebuck (2) The present review stresses work of immediate interest to immunologists. It also outlines briefly the cells involved and their interrelationships because both subjects are fundamental to an understanding of the cellular aspects of immunity. The coverage, as a result, although largely limited to the last 10 years, has been selective, particularly as regards the latter aim, and includes some older work for purposes of orientation. CONNECTIVE TISSUE CELLS INVOLVED IN IMMUNITYThe cells involved in immunity are listed in Table I together with the systems into which they have been incorporated (d. 3) 159 Annu. Rev. Microbiol. 1949.3:159-194. Downloaded from www.annualreviews.org Access provided by University of California -San Diego on 02/03/15. For personal use only. Quick links to online content Further ANNUAL REVIEWS

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INFLUENCE OF HORMONES ON LYMPHOID TISSUE STRUCTURE AND FUNCTION. THE ROLE OF THE PITUITARY ADRENOTROPHIC HORMONE IN THE REGULATION OF THE LYMPHOCYTES AND OTHER CELLULAR ELEMENTS OF THE BLOOD¹

Cited by 246 publications

References 0 publications

Blood Levels of 17-Hydroxycorticosteroids Following the Administration of Adrenal Steroids and Their Relation to Levels of Circulating Leukocytes 1

Blood Levels of 17-Hydroxycorticosteroids Following the Administration of Adrenal Steroids and Their Relation to Levels of Circulating Leukocytes 1

Plasma Corticosteroid, Circulating Leukocyte and Milk Somatic Cell Responses to Escherichia coli Endotoxin-Induced Mastitis

The Cellular Basis of Immunity

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INFLUENCE OF HORMONES ON LYMPHOID TISSUE STRUCTURE AND FUNCTION. THE ROLE OF THE PITUITARY ADRENOTROPHIC HORMONE IN THE REGULATION OF THE LYMPHOCYTES AND OTHER CELLULAR ELEMENTS OF THE BLOOD1

Cited by 246 publications

References 0 publications

Blood Levels of 17-Hydroxycorticosteroids Following the Administration of Adrenal Steroids and Their Relation to Levels of Circulating Leukocytes 1

Blood Levels of 17-Hydroxycorticosteroids Following the Administration of Adrenal Steroids and Their Relation to Levels of Circulating Leukocytes 1

Plasma Corticosteroid, Circulating Leukocyte and Milk Somatic Cell Responses to Escherichia coli Endotoxin-Induced Mastitis

The Cellular Basis of Immunity

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INFLUENCE OF HORMONES ON LYMPHOID TISSUE STRUCTURE AND FUNCTION. THE ROLE OF THE PITUITARY ADRENOTROPHIC HORMONE IN THE REGULATION OF THE LYMPHOCYTES AND OTHER CELLULAR ELEMENTS OF THE BLOOD¹