Influence of HMG–CoA reductase inhibitors on markers of coagulation, systemic inflammation and soluble cell adhesion

Effect of statins and white blood cell count on mortality in patients with ischemic left ventricular dysfunction undergoing percutaneous coronary intervention

“…We believe the large difference in survival for patients treated with statin therapy or not (97 vs. 84% at 1-year follow-up) may be due to the many actions of statins. Potential mechanisms include reduced inflammation, 10,11 reduced ischemia, 17,18 improved LV function, 14,15 and/or other pleiotropic effects, 19,20 all effects of statin therapy that reduce the likelihood of mortality in this high-risk population.…”

“…6,7 It is also known that patients with elevated white blood cell (WBC) counts on admission for acute MI have worse survival than patients with normal WBC counts. 8,9 Previous studies on patients with normal LV function have shown that statins may reduce inflammation 10,11 and improve survival in patients with inflammation. 12,13 While statins have been shown to reduce LV mass 14 and improve LV function in animals, 15 we hypothesize that the anti-inflammatory effects of statin therapy may provide additional improvement in survival for patients with LV dysfunction and an elevated WBC count.…”

ICAM-1: Contribution to Vascular Inflammation and Early Atherosclerosis

“…Increased levels of sICAM-1 were also found in type 2 diabetic patients (Becker, van Hinsbergh et al 2002). Serum levels of sICAM-1 in cardiovascular patients treated with statins were confirmed to be lower in some groups (Romano, Mezzetti et al 2000;Blann, Gurney et al 2001;Bickel, Rupprecht et al 2002), whereas some studies could not find a significant reduction (Rauch, Osende et al 2000;Jilma, Joukhadar et al 2003).…”

Statin as an Anti-Inflammatory Agent in Sepsis

“…Statins also significantly decrease sepsis induced leucocyte recruitment, adhesion and transmigration. These effects were attributed to decrease MCP-1, IL-8, exotoxin induced leucocyte rolling, up-regulation of tol-llike receptors (TLR) 4 and 2 on the surface of monocytes [50], an adhesion molecule E-selectin expression on the EC [51], and direct inhibition of CD11a/CD18 or lymphocyte function antigen-1 (LFA-1)-mediated leucocyte adhesion [52;53]. Suppressed TLR4 and TLR2 expression was associated with decreased circulating concentrations of TNF-α and MCP-1 [50].…”