Influence of HLA-C Matching on aGvHD of Unrelated and Family Donor Hematopoietic Stem Cell Transplantation in Pediatric Patients with Hematologic Malignancies.
Abstract:With a continuous decrease in family size, identification of an HLA identical sibling donor for allogeneic hematopoietic stem cell transplantation (HSCT) is often unsuccessful. High resolution HLA-Typing of HLA class I and II loci has opened new avenues for identification of the optimal unrelated donor. Yet, the role of HLA-C matching in HSCT remains controversial. This is particularly true for pediatric transplantation recipients in whom currently little data are available. Here we report on the role of HLA-C… Show more
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