Influence of Histologic Type and Age on Survival Rates for Invasive Cervical Carcinoma in Taiwan

Chen, Ruey-Jien; Lin, Yu‐Hung; Chen, Chi-An; Huang, Su‐Cheng; Chow, Song‐Nan; Hsieh, Chang‐Yao

doi:10.1006/gyno.1999.5364

Cited by 100 publications

(52 citation statements)

References 32 publications

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“…Secondly, lead-time bias will increase age in early stages and decrease age in advanced stages if advancing stages are expected due to aggressive behaviour of the tumor [13]. Thirdly, if survival depends on age it may do so differentially according to tumor type [20]. Due to design and the limited number of women we cannot exclude these effects.…”

Section: Discussionmentioning

confidence: 99%

“…Primarily, the time of diagnosis may be influenced by changing incidences as adenocarcinoma is increasing over time, presumably due to increased use of hormonal anticonception [6,7,20]. Secondly, lead-time bias will increase age in early stages and decrease age in advanced stages if advancing stages are expected due to aggressive behaviour of the tumor [13].…”

Section: Discussionmentioning

confidence: 99%

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Mixed Adenosquamous Histology is Associated with Poorer Survival of Cervical Cancer Stage 1b

Lauszus

Al-Far²,

Tjessem³

et al. 2016

IJCR

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IntroductionCervical cancer is staged preoperatively and the postoperative treatment depends on the combination of staging with histopathological finding. Survival is related to certain histopathological factors, most importantly lymph node status and other findings indicating that tumor may have spread i.e. parametrium and the lymph-vascular space. Other factors like tumor size and depth of stromal invasion indicate aggressive biological behavior. Poorer survival depending on histological type of tumor is reported in adenocarcinoma compared to squamous carcinoma [1][2][3][4][5][6][7]. The concurrent increasing incidence of adenocarcinoma associated with use of oral contraceptives in the Western World is a concern to that it may reverse the positive effect of screening [6,7]. However, the survival relates heavily on different pre-and postoperative treatment regimens and stage of disease [1,3,4]. Adverse histopathological factors are often present simultaneously and reviewed heterogeneously.The aim of our study was to evaluate independent histopathological factors for women with radical hysterectomy with focus on standardized histopathological diagnosis combined with similar pre-and postoperative treatment. Material and Methods141 women were diagnosed with cervical cancer stage 1b and operated with radical hysterectomy during 24 years at Holstebro Hospital. The hospital served as centre for the county with a population of approximately 275.000. The stage, pre-and postoperative treatment was registered as the data charts were reviewed. The local patient registry provided information of survival, relapse, and re-admittance. None of the women was lost to follow-up. Data charts or post mortem sections confirmed the cause of death. AbstractBackground: Evaluation of histopathological factors for women with radical hysterectomy a.m. Okabayashi for cervical cancer in stage 1bwith similar pre-and postoperative treatment Methods: Data on 141 women with cervical cancer stage 1b were revised. The local patient registry, data charts, and post mortem sections provided follow-up on survival, relapse, and re-admittance. Histopathological evaluation was performed by the same pathologist. Results: Histological evaluation showed that adenosquamous cervical cancer in stage 1b was associated with poorer survival than the pure squamous and adenomatous type (p<0.001, mixed versus pure type). Five year's survival rate was 40 % (2-78 %) for mixed type and 92 % (87-97 %) for pure type. The mixed type was associated with glandular metastasis (p<0.02). The relapse free survival after 5 and 10 years was 88 % (82-94 %) and 83 % (75-91 %), respectively, while survival was found to be 89 % (83-95 %) and 86 % (79-93 %), respectively. The women's age at diagnosis showed no association with histology type or survival.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Mixed Adenosquamous Histology is Associated with Poorer Survival of Cervical Cancer Stage 1b

Lauszus

Al-Far²,

Tjessem³

et al. 2016

IJCR

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“…Patient age has also been shown to be an independent prognostic factor in cases of cervical cancer, with a decrease in recurrence rate and an increase in survival rate associated with advanced age (Turan et al, 2010). However, other studies have indicated that a younger age is an advantage for survival (Chen et al, 1999;Bulk et al, 2003) and that age has not any prognostic value on survival rate (Ho et al, 2004;Behtash et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

Ovarian Transposition for Stage Ib Squamous Cell Cervical Cancer - Lack of Effects on Survival Rates?

Turan

Keskin²,

Dündar³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Background: To investigate the impact of ovarian transposition (OT) on survival rates of the patients with stage Ib squamous cell cervical cancer. Materials and Methods: Ninety-two subjects who underwent a radical hysterectomy including oophorectomy were evaluated. For nineteen (20.7%) , OT was performed. Patients were divided into two groups, OT versus oophorectomy alone. The primary end-point of this study was to investigate the impact of OT on tumor recurrence rate and time, 5-year disease-free survival (DFS) and overall survival (OS) . These comparisons were performed for subgroups including patients who received radiotherapy versus who did not. Statistical analyses were conducted using the Chi-square test, T-test and Mann-Whitney test. OS was examined using the Kaplan-Meier method. P≤0.05 was considered to be statistically significant. Results: The median follow-up period was 89 months for OT and 81 months for the oophorectomy group (p>0.05). Both groups experienced similar recurrence rates (31.6% vs. 26.4%, p=0.181). The median duration from surgery to recurrence, and surgery to death were also similar between the groups (p>0.05). The 5-year DFS and OS rates were both 68.4% for the OT group, and 73.6% and 77.8% for the oophorectomy group (p=0.457 and p=0.307, respectively). While the 5-year DFS rate was not statistically significant between the OT and oophorectomy groups who did not receive radiotherapy (p=0.148), the 5-year OS rate was significantly higher in the oophorectomy group (95.4% vs 66.7%, respectively) without radiotherapy (p=0.05). The 5-year DFS and OS rates were statistically similar between the groups who received adjuvant radiotherapy (p>0.05). Conclusions: Ovarian transposition has not significantly negative effect on the survival rates when adjuvant radiotherapy will be applied, while 5-year OS may be less in OT group if radiotherapy is not mandatory.

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“…Other studies have provided discrepant results. 9,11,18,19,21,22,25,27,29,35,39 This may be due to the inclusion of histologic groups of patient with adenosquamous carcinoma 11,22,25 or clear cell carcinoma 11 in the other studies or to the use of different grading systems. 9,25,35 When comparing the prognosis for patients with glandular and nonglandular carcinomas of the uterine cervix, several authors have found inferior survival for patients with glandular tumors.…”

Section: Discussionmentioning

confidence: 99%

“…9,25,35 When comparing the prognosis for patients with glandular and nonglandular carcinomas of the uterine cervix, several authors have found inferior survival for patients with glandular tumors. 3,5,10,23,26,34,36,39,40 Because of these differences, speculations have been made on the relevance of a similar grading system for patients with glandular and nonglandular carcinomas of the uterine cervix. Glandular tumors of the uterine cervix may have more in common with endometrial carcinomas than with cervical SCCs, and their biologic properties may not be reflected in a staging system based on tumors that arise from the squamous epithelium in the distal part of the organ.…”

Section: Discussionmentioning

confidence: 99%

Histologic subtype has minor importance for overall survival in patients with adenocarcinoma of the uterine cervix

Alfsen

Kristensen

Skovlund

et al. 2001

Cancer

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Influence of Histologic Type and Age on Survival Rates for Invasive Cervical Carcinoma in Taiwan

Cited by 100 publications

References 32 publications

Mixed Adenosquamous Histology is Associated with Poorer Survival of Cervical Cancer Stage 1b

Mixed Adenosquamous Histology is Associated with Poorer Survival of Cervical Cancer Stage 1b

Ovarian Transposition for Stage Ib Squamous Cell Cervical Cancer - Lack of Effects on Survival Rates?

Histologic subtype has minor importance for overall survival in patients with adenocarcinoma of the uterine cervix

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