The effects of vacuum, solar, convective, infrared and freeze drying (VD, SD, CD, IRD, FD) on Durvillaea antarctica were evaluated in terms of nutritional composition, color, bioactive components, and antioxidant and anti-diabetic activities. Nutritional composition of the dried seaweeds scarcely varied, while a tendency to lose the reddish tone occurred. CDseaweed had highest phytochemical and vitamin contents, while FDsamples showed best retention of pigments. Both samples also exhibited the strongest antioxidant and antidiabetic activities. The highest essential amino acids and polyunsaturated fatty acids contents were found in IRDand SD-samples respectively. In general, FD and CD proved to be viable drying options for D. antarctica.Keywords: brown seaweed Durvillaea antarctica; drying methods; bioactive components; antidiabetic properties; amino acids; fatty acids USA) until analysis. All drying assays were performed in triplicate.FD of the fresh seaweeds (0.500 kg) was performed using a freeze-dryer (Virtis Advantage Plus, Gardiner, NY, USA). The sample was first frozen at -80 °C for 24 h, then placed horizontally onto two drying trays at a charge density of 6.08 kg/m 2 and dried in the primary drying phase programed from -50 to 20 °C followed by the secondary drying phase at 20 °C under vacuum (0.027 kPa) for 72 h. CD was performed in a convective dryer as described by Uribe et al.[10] at 60±0.2 °C with 1.200 kg fresh samples evenly arranged on two stainless steel trays at a load density of 6.28 kg/m 2 under a constant air flow of 1.5±0.2 m/s. VD was performed at 60±0.2 °C and 15 kPa in a vacuum oven (Memmert VO400, Schwabach, Germany) for 480 min with the samples (0.500 kg) placed on stainless steel trays at a load density of 4.13 kg/m 2 . SD was