Influence of High- and Low-Dose Aprotinin on Activation of Hemostasis in Open Heart Operations

Dietrich, Wulf; Schöpf, K.; Spannagl, Michael; Jochum, Marianne; Braun, Siegmund; Meisner, H

doi:10.1016/s0003-4975(97)01123-5

Cited by 33 publications

(18 citation statements)

References 29 publications

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“…Four studies were excluded because of insufficient data to judge the study design. [27][28][29][30] One trial 31 used viscoelastic testing algorithms in the control group, and one 32 randomized abdominal aortic aneurysm surgeries. Two trials (NCT00772239; NCT01218074) were published only as protocols without any data available.…”

Section: Excluded Studiesmentioning

confidence: 99%

Routine use of viscoelastic blood tests for diagnosis and treatment of coagulopathic bleeding in cardiac surgery: updated systematic review and meta-analysis

Serraino

Murphy

2017

British Journal of Anaesthesia

153

123

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Viscoelastic point-of-care tests are commonly used to provide prompt diagnosis of coagulopathy and allow targeted treatments in bleeding patients. We updated existing meta-analyses that have evaluated the clinical effectiveness of viscoelastic point-of-care tests vs the current standard of care for the management of cardiac surgery patients at risk of coagulopathic bleeding. Randomized controlled trials comparing viscoelastic point-of-care diagnostic testing with standard care in cardiac surgery patients were sought. All-cause mortality, blood loss, reoperation, blood transfusion, major morbidity, and intensive care unit and hospital length of stay were analysed using random-effects modelling. Fifteen trials that randomized a total of 8737 participants were included for the analysis. None of the trials was classified as low risk of bias. The use of thromboelastography-(TEG V R ) or thromboelastometry (ROTEM V R )-guided algorithms did not reduce mortality [risk ratio (RR) 0.55, 95% confidence interval (CI) 0.28-1.10] without heterogeneity (I

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Section: Excluded Studiesmentioning

confidence: 99%

Routine use of viscoelastic blood tests for diagnosis and treatment of coagulopathic bleeding in cardiac surgery: updated systematic review and meta-analysis

Serraino

Murphy

2017

British Journal of Anaesthesia

153

123

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“…22,23 Aprotinin was administered in about 50% of patients, using the Hammersmith regimen as it appears to be the most effective and also the safer one. 24,25 Hypothermia has been shown to significantly increase postoperative blood loss, probably by impairing platelet function and reducing clotting factor function. 26 Rewarming after bypass was more vigorous in Group post patients who had a higher core temperature on arrival in the ICU.…”

Section: The Blood Conservation Programmentioning

confidence: 99%

A standardized multidisciplinary approach reduces the use of allogeneic blood products in patients undergoing cardiac surgery

et al. 2001

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“…Four studies were excluded because of insufficient data to judge the study design. [149][150][151][152] In the trial by Agarwal et al,…”

Section: Excluded Studiesmentioning

confidence: 99%

Diagnostic and therapeutic medical devices for safer blood management in cardiac surgery: systematic reviews, observational studies and randomised controlled trials

Murphy

Mumford

Rogers

et al. 2017

Programme Grants Appl Res

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This report should be referenced as follows:Murphy GJ, Mumford AD, Rogers CA, Wordsworth S, Stokes EA, Verheyden V, et al. Diagnostic and therapeutic medical devices for safer blood management in cardiac surgery: systematic reviews, observational studies and randomised controlled trials. Programme Grants Appl Res 2017;5(17). Programme Grants for Applied ResearchISSN 2050-4322 (Print) ISSN 2050-4330 (Online) This journal is a member of and subscribes to the principles of the Committee on Publication Ethics (COPE) (www.publicationethics.org/).Editorial contact: journals.library@nihr.ac.ukThe full PGfAR archive is freely available to view online at www.journalslibrary.nihr.ac.uk/pgfar. Print-on-demand copies can be purchased from the report pages of the NIHR Journals Library website: www.journalslibrary.nihr.ac.uk Criteria for inclusion in the Programme Grants for Applied Research journalReports are published in Programme Grants for Applied Research (PGfAR) if (1) they have resulted from work for the PGfAR programme, and (2) they are of a sufficiently high scientific quality as assessed by the reviewers and editors. Programme Grants for Applied Research programmeThe Programme Grants for Applied Research (PGfAR) programme, part of the National Institute for Health Research (NIHR), was set up in 2006 to produce independent research findings that will have practical application for the benefit of patients and the NHS in the relatively near future. The Programme is managed by the NIHR Central Commissioning Facility (CCF) with strategic input from the Programme Director.The programme is a national response mode funding scheme that aims to provide evidence to improve health outcomes in England through promotion of health, prevention of ill health, and optimal disease management (including safety and quality), with particular emphasis on conditions causing significant disease burden.For more information about the PGfAR programme please visit the website: http://www.nihr.ac.uk/funding/programme-grants-forapplied-research.htm This reportThe research reported in this issue of the journal was funded by PGfAR as project number RP-PG-0407-10384. The contractual start date was in July 2008. The final report began editorial review in July 2016 and was accepted for publication in April 2017. As the funder, the PGfAR programme agreed the research questions and study designs in advance with the investigators. The authors have been wholly responsible for all data collection, analysis and interpretation, and for writing up their work. The PGfAR editors and production house have tried to ensure the accuracy of the authors' report and would like to thank the reviewers for their constructive comments on the final report document. However, they do not accept liability for damages or losses arising from material published in this report.This report presents independent research funded by the National Institute for Health Research (NIHR). The views and opinions expressed by authors in this publication are those of the authors and do not ...

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Influence of High- and Low-Dose Aprotinin on Activation of Hemostasis in Open Heart Operations

Cited by 33 publications

References 29 publications

Routine use of viscoelastic blood tests for diagnosis and treatment of coagulopathic bleeding in cardiac surgery: updated systematic review and meta-analysis

Routine use of viscoelastic blood tests for diagnosis and treatment of coagulopathic bleeding in cardiac surgery: updated systematic review and meta-analysis

A standardized multidisciplinary approach reduces the use of allogeneic blood products in patients undergoing cardiac surgery

Diagnostic and therapeutic medical devices for safer blood management in cardiac surgery: systematic reviews, observational studies and randomised controlled trials

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