Influence of high altitude on the expression of HIF-1 and on the prognosis of Ecuadorian patients with gastric adenocarcinoma

Barrera, Edwin Cevallos; Martínez, Edson Zangiacomí; Brunaldi, Mariângela Ottoboni; Donadi, Eduardo Antônio; Sankarankutty, Ajith Kumar; Kemp, Rafael; Santos, José Sebastião dos

doi:10.18632/oncotarget.28275

Cited by 2 publications

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“…The findings of the present study suggested that diets consumed at high altitudes could be energy-dense, containing high amounts of fat and protein, as revealed by a comparison of calorie composition (11,37). Consistent with previous studies, the Jiarong Tibetans' diet in the HA group was found to be rich in fat, providing up to 50% of their energy intake.…”

Section: Discussionsupporting

confidence: 90%

“…Several studies have previously concentrated on the influences of genetics, gut microbiota, and plateau environment on the Tibetan population’s ability to metabolize lipids ( 14 , 37 , 39 ). In the present study, the association between Tibetan dietary intake and lipid levels was further analyzed at different altitudes, after adjusting for age, educational level, monthly income, and smoking status ( Table 4 ).…”

Section: Discussionmentioning

confidence: 99%

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Lipid levels in the Jiarong Tibetan’s diet at high altitudes: a cross-sectional survey

Xiaoyue,

Qichuan,

Jing

et al. 2023

Front. Nutr.

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Despite the ongoing debate on the inconsistent and controversial effects of Tibetan diet on blood lipid levels at high altitude, this cross-sectional study was conducted to analyze the relationship between dietary practices and blood lipid levels among Jiarong Tibetan population. A total of 476 Jiarong Tibetan residents were included, in which basic demographic data, physical activity records, simplified food frequency questionnaire, and biochemical data were collected. Using multivariate logistic regression analysis, the potential associations between the variables were examined, and it was found that fat energy supply ratio increased with the elevation of altitude, while the lipid level showed an inverted U-shaped variation. However, the findings suggested that a diet rich in unsaturated fatty acids might balance the effects of the Tibetan diet on the risk of lipid metabolism disorders. Therefore, it is crucial to concentrate on the fat composition rather than the amount of fat E% intake on the plateau. The results highlighted the importance of investigating the interaction between environment and genes in lipid levels among plateau Tibetan population. However, further large-scale prospective studies are required for better understanding of the complexities involved in dietary practices and their influences on blood lipid levels.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Lipid levels in the Jiarong Tibetan’s diet at high altitudes: a cross-sectional survey

Xiaoyue,

Qichuan,

Jing

et al. 2023

Front. Nutr.

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Relationship between serum iron, zinc, calcium, and HIF-1a—comparative analysis of 2 regions and 4 ethnic groups in China

Guo,

Lu,

Zhang

et al. 2024

Front. Nutr.

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BackgroundAltitude illness has serious effects on individuals who are not adequately acclimatized to high-altitude areas and may even lead to death. However, the individualized mechanisms of onset and preventive measures are not fully elucidated at present, especially the relationship between altitude illness and elements, which requires further in-depth research.MethodsFresh serum samples were collected from individuals who underwent health examinations at the two hospitals in Xining and Sanya between November 2021 and December 2021. The blood zinc (Zn), iron (Fe), and calcium (Ca) concentrations, as well as hypoxia-inducible factor 1-alpha (HIF-1α) concentrations, were measured. This study conducted effective sample size estimation, repeated experiments, and used GraphPad Prism 9.0 and IBM SPSS version 19.0 software for comparative analysis of differences in the expression of elements and HIF-1α among different ethnic groups, altitudes, and concentration groups. Linear regression and multiple linear regression were employed to explore the relationships among elements and their correlation with HIF-1α.ResultsThis study included a total of 400 participants. The results from the repeated measurements indicated that the consistency of the laboratory test results was satisfactory. In terms of altitude differences, except for Fe (p = 0.767), which did not show significant variance between low and high altitude regions, Zn, Ca, and HIF-1α elements all exhibited notable differences between these areas (p < 0.0001, p = 0.004, and p < 0.0001). When grouping by the concentrations of elements and HIF-1α, the results revealed significant variations in the distribution of zinc among different levels of iron and HIF-1α (p < 0.05). The outcomes of the linear regression analysis demonstrated that calcium and zinc, iron and HIF-1α, calcium and HIF-1α, and zinc and HIF-1α displayed substantial overall explanatory power across different subgroups (p < 0.05). Finally, the results of the multiple linear regression analysis indicated that within the high-altitude population, the Li ethnic group in Sanya, and the Han ethnic group in Sanya, the multiple linear regression model with HIF-1αas the dependent variable and elements as the independent variables exhibited noteworthy overall explanatory power (p < 0.05).ConclusionThe levels of typical elements and HIF-1α in the blood differ among various altitudes and ethnic groups, and these distinctions may be linked to the occurrence and progression of high-altitude illness.

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Influence of high altitude on the expression of HIF-1 and on the prognosis of Ecuadorian patients with gastric adenocarcinoma

Cited by 2 publications

References 20 publications

Lipid levels in the Jiarong Tibetan’s diet at high altitudes: a cross-sectional survey

Lipid levels in the Jiarong Tibetan’s diet at high altitudes: a cross-sectional survey

Relationship between serum iron, zinc, calcium, and HIF-1a—comparative analysis of 2 regions and 4 ethnic groups in China

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