Influence of heredity in the etiology of malocclusion

Stein, Kathryn F.; Kelley, Thomas J.; Wood, Eunice

doi:10.1016/0002-9416(56)90073-2

Cited by 48 publications

(10 citation statements)

References 28 publications

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“…33,36 From that point on, during the late 1930s and throughout the 1950s, much of orthodontic research focused on family pedigrees and especially on the study of twins from the perspectives of Mendelian genetics. [37][38][39][40][41][42][43] Virtually all of those studies tended to support the newly popular opinion that heredity determines the size and shape of the jaws in both normal and abnormal development and growth. 33,44,45 Thus, by the 1940s, opinions among most orthodontic educators and researchers had switched from abrogation of heredity as the primary factor determining normal and abnormal dentofacial growth and form to the position that "today, the hereditary factors are considered first in importance and [local environmental] factors second in the process of growth and development."…”

Section: Concepts Of Heredity and Genetics In Orthodonticsmentioning

confidence: 99%

Evolving concepts of heredity and genetics in orthodontics

Carlson

2015

American Journal of Orthodontics and Dentofacial Orthopedics

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The field of genetics emerged from the study of heredity early in the 20th century. Since that time, genetics has progressed through a series of defined eras based on a number of major conceptual and technical advances. Orthodontics also progressed through a series of conceptual stages over the past 100 years based in part on the ongoing and often circular debate about the relative importance of heredity (nature) and the local environment (nurture) in the etiology and treatment of malocclusion and dentofacial deformities. During the past 20 years, significant advancements in understanding the genomic basis of craniofacial development and the gene variants associated with dentofacial deformities have resulted in a convergence of the principles and concepts in genetics and in orthodontics that will lead to significant advancement of orthodontic treatments. Fundamental concepts from genetics and applied translational research in orthodontics provide a foundation for a new emphasis on precision orthodontics, which will establish a modern genomic basis for major improvements in the treatment of malocclusion and dentofacial deformities as well as many other areas of concern to orthodontists through the assessment of gene variants on a patient-by-patient basis.

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Section: Concepts Of Heredity and Genetics In Orthodonticsmentioning

confidence: 99%

Evolving concepts of heredity and genetics in orthodontics

Carlson

2015

American Journal of Orthodontics and Dentofacial Orthopedics

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“…Malokluzyonun gelifliminde ayn› flekilde genetik faktörler de etkilidir. Tek-çift yumurta ikizleri ve farkl› popülasyonlardan çok say›da aile üzerinde yap›lan kal›t›m çal›flmalar›nda oj, ark boyu, cross-bite ve bireysel difl malpozisyonunun genetik komponentleriyle ilgili sa¤lam kan›tlar bulunmufltur (42)(43)(44)(45)(46)(47). Genel olarak herediter faktörlerin önemi malokluzyonun fliddeti artt›kça artmaktad›r (44,29).…”

Section: De Er Rl Le Em Me E / / D De Er Rl Le Em Me E / / R Re Ev unclassified

“…Studies of heritability in monozygotic and dizygotic twins and in large samples of families from different populations reveal strong evidence of a genetic component for overjet, arch size, cross-bite, and individual tooth displacement (42)(43)(44)(45)(46)(47). The importance of hereditary factors generally increases with the severity of malocclusions (44,29).…”

Section: De Er Rl Le Em Me E / / D De Er Rl Le Em Me E / / R Re Ev mentioning

confidence: 99%

Maloklüzyonlarm Oluşumu Üzerine Genetik Faktörlerin Etkisi

SAKİN¹,

Kurt²

2009

Turkish Journal of Orthodontics

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“…Early traditional twin studies 27 and intrafamilial comparisons 28 indicated that occlusal traits were under reasonably strong genetic control. However, more recent reports in twins 29 and in first-degree r e l at i ve s 3 0 , 3 1 h ave emphasized the importance of environmental factors.…”

Section: Heritabilitymentioning

confidence: 99%

Genetic aspects of dental disorders

Townsend

Aldred

Bartold

1998

Australian Dental Journal

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This paper reviews past and present applications of quantitative and molecular genetics to dental disorders. Examples are given relating to craniofacial development (including malocclusion), oral supporting tissues (including periodontal diseases) and dental hard tissues (including defects of enamel and dentine as well as dental caries). Future developments and applications to clinical dentistry are discussed. Early investigations confirmed genetic bases to dental caries, periodontal diseases and malocclusion, but research findings have had little impact on clinical practice. The complex multifactorial aetiologies of these conditions, together with methodological problems, have limited progress until recently. Present studies are clarifying previously unrecognized genetic and phenotypic heterogeneities and attempting to unravel the complex interactions between genes and environment by applying new statistical modelling approaches to twin and family data. Linkage studies using highly polymorphic DNA markers are providing a means of locating candidate genes, including quantitative trait loci (QTL). In future, as knowledge increases; it should be possible to implement preventive strategies for those genetically-predisposed individuals who are identified to be at risk.

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Influence of heredity in the etiology of malocclusion

Cited by 48 publications

References 28 publications

Evolving concepts of heredity and genetics in orthodontics

Evolving concepts of heredity and genetics in orthodontics

Maloklüzyonlarm Oluşumu Üzerine Genetik Faktörlerin Etkisi

Genetic aspects of dental disorders

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