Influence of hepatitis B virus genotype on the long-term outcome of chronic hepatitis B in western patients

Sánchez-Tapias, J.M.; Costa, Josep; Mas, Antoni; Bruguera, Miquel; Rodés, Juan

doi:10.1053/gast.2002.37041

Cited by 380 publications

(328 citation statements)

References 43 publications

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“…Genotypes A and D were predominant in both group of individuals. This distribution is similar to other European studies that confirm the predominance of these two genotypes, particularly in Mediterranean countries (Basaras et al, 2007;Echevarria and Leon, 2004;Sanchez-Tapias et al, 2002). In our group of individuals, no relationships between HBV genotypes and the presence of extrahepatic manifestations were evidenced in patients with chronic HBV infection.…”

Section: Discussionsupporting

confidence: 91%

Alcohol consumption among patients with hepatitis B infection in northern Portugal considering gender and hepatitis B virus genotype differences

Mota¹,

Guedes²,

Areias³

et al. 2010

Alcohol

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Alcohol abuse is an important public health problem. In Portugal with a population of 10 millions of inhabitants, there are around 10% of alcoholics or excessive alcohol drinkers and 1% of chronically infected patients with hepatitis B virus (HBV). To examine the characteristics of patients with higher levels of alcohol consumption and to investigate the association between alcohol consumption and liver damage a total of 298 chronically infected individuals, with HBV genotyped and submitted to liver biopsy, were classified with Child's grading and separated by habits of alcohol intake, less and greater than 20 g/day. No significant differences were observed about genotype but genotypes A and D were predominant in both of them. A higher percentage of males (P ! .001) were observed in the group with alcohol intake above 20 g/day, as well a lower proportion of patients with HBeAg negativity (P #.035). In this group, biochemistry parameters, such as alanine aminotransferase (P 5 .006), aspartate aminotransferase (P 5 .001), gamma-glutamyl transferase (P ! .001) were elevated in a significantly higher proportion than in the other group. The analysis of hematological parameters showed significantly lower values of platelets (P 5 .042) and mean corpuscular volume (P ! .001) and significantly higher values of prothrombin time (P ! .001) in the group with higher levels of alcohol consumption. The characteristics of biopsy (P ! .001) and ChildePhug's classification (P 5 .002) revealed more severe results in this group. Logistic regression showed a positive association between liver damage and alcohol intake, increasing with age. In female patients, a strong positive association between alcohol intake and liver damage was also found (odds ratio: 9.379; 95% confidence interval: 0.859e468.422; P 5 .037); however, the most severe cases were only observed in women older than 45 years. In patients with HBV infection, alcohol is associated with a more severe liver disease. No evidence was found concerning association with HBV genotype. Ó

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Section: Discussionsupporting

confidence: 91%

Alcohol consumption among patients with hepatitis B infection in northern Portugal considering gender and hepatitis B virus genotype differences

Mota¹,

Guedes²,

Areias³

et al. 2010

Alcohol

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“…Persistence of an acute HBV infection to chronicity has been shown to be more likely when infection occurs with either genotype A or D compared to genotypes B or C [60][61]. Progression to HCC and cirrhosis has been shown to be more common in genotype C carriers versus genotype B, depending on age, and in patients infected with genotype D or F compared to genotype A [62][63][64]. Interestingly, subgenotype B5 infection, the dominant genotype studied in this investigation, has a very low incidence for any severe disease outcome, and will be discussed later in this article.…”

Section: Genotypesmentioning

confidence: 99%

Serological and molecular epidemiological outcomes after two decades of universal infant hepatitis B virus (HBV) vaccination in Nunavut, Canada

Huynh¹,

Minuk

Uhanova

et al. 2017

Vaccine

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“…These genotypes have a distinct geographical distribution, with genotypes A (HBV/A) and HBV/ D predominant in Europe, Middle East, Central Asia, Siberia, and America, HBV/B and HBV/C in East Asia, and HBV/E in Africa. In addition, HBV/F has been reported in Central America, and HBV/G in the United States and France [Norder et al, 1993;Lindh et al, 1997;Sanchez-Tapias et al, 2002;Chu et al, 2003;Miyakawa and Mizokami, 2003;Deversa et al, 2004;Mulders et al, 2004;Tallo et al, 2004]. In Japan, HBV/C is the most prevalent, followed by HBV/B, while others are encountered very rarely.…”

Section: Introductionmentioning

confidence: 99%

Tracing the history of hepatitis B virus genotype D in western Japan

Michitaka

Tanaka

Horiike

et al. 2005

Journal of Medical Virology

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The major hepatitis B virus (HBV) genotypes in Japan are B and C. HBV genotype D (HBV/D), however, is widespread in a small area of Western Japan, where the Gianotti-Crosti syndrome caused by HBV subtype ayw, which is suspected to be HBV/D, was endemic in the 1970s. The aim of the study was to elucidate its origin, time of transmission, and spread in this area. Genotyping of HBV-DNA was done in 363 patients with HBV infection. The year of birth was checked in patients with HBV/D. The full genome sequences of 20 HBV/D strains, 2 of which were obtained from a single carrier with a 19-yearinterval, were analyzed. An evolutionary rate, the date of the most recent common ancestor, and the effective number of HBV/D infections were calculated. Fifty-two of 363 patients were infected with HBV/D, and 39 were born in 1970s. In a phylogenetic tree, the 20 HBV/D strains produced a definite cluster, and the evolutionary rate was calculated to be 5.4 Â 10 À5 nucleotide substitutions/site/year. The root of the tree was estimated to be in approximately 1,900 and began to spread from the 1940s, leading to a rapid increase of infected patients in the 1970s. From these results, it is suspected that HBV/D was likely transmitted to the area investigated approximately 100 years ago and then spread widely in the 1970s. From the history of the area and the genetic analysis, HBV/ D in this area was speculated to be of Russian origin.

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Influence of hepatitis B virus genotype on the long-term outcome of chronic hepatitis B in western patients

Cited by 380 publications

References 43 publications

Alcohol consumption among patients with hepatitis B infection in northern Portugal considering gender and hepatitis B virus genotype differences

Alcohol consumption among patients with hepatitis B infection in northern Portugal considering gender and hepatitis B virus genotype differences

Serological and molecular epidemiological outcomes after two decades of universal infant hepatitis B virus (HBV) vaccination in Nunavut, Canada

Tracing the history of hepatitis B virus genotype D in western Japan

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