Influence of Hepatitis B Virus (HBV) Genotype on the Clinical Course of Disease in Patients Coinfected with HBV and Hepatitis Delta Virus

Kiesslich, Dagmar; Crispim, Myuki Alfaia Esashika; Santos, Carlos Alexandre dos; Ferreira, Fernando de Lima; Fraiji, Nelson Abrahim; Komninakis, Shirley Vasconcelos; Diaz, Ricardo Sobhie

doi:10.1086/598955

Cited by 50 publications

(43 citation statements)

References 10 publications

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“…26,56 The low HBV viral load among those HBsAg positive individuals is probably caused by the HDV coinfection that may spontaneously suppress HBV. 47,[54][55][56][57][58] This study is a continuation of two previous studies 2,15 to define the most important aspects of HBV infection epidemiology in this region described as highly endemic. A pattern is outlined in which pockets of chronic HBV carriers are identified where potential reservoirs are concentrated.…”

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confidence: 79%

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Epidemiology and Molecular Characterization of Hepatitis B Virus Infection in Isolated Villages in the Western Brazilian Amazon

Castilho

Oliveira

Gimaque

et al. 2012

The American Journal of Tropical Medicine and Hygiene

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Abstract. Individuals from three isolated, rural communities in the western Brazilian Amazon were evaluated for serological markers of hepatitis B virus (HBV) infection, HBV genotype, and the presence of risk factors for infection and transmission. Of the 225 individuals studied, 79.1% had serological evidence of HBV infection; 10.2% individuals were chronic carriers for HBV surface antigen (HBsAg-positive). Analysis of risk factors indicates that HBV is transmitted mainly horizontally within the family from a chronic "active" carrier for hepatitis B "e" antigen (HBeAgpositive), though a strong possibility of vertical transmission remains. The predominance of HBV genotype F, with a higher genomic similarity between the isolates, indicated a relatively recent introduction of HBV, from a common source, to the area. This study sheds light on the HBV epidemiology in the Brazilian Amazon region and highlights the need for greater emphasis on HBV control and immunization programs.

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confidence: 79%

“…45,46 Genotype F has frequently been described in the Amazon, 17,26,[47][48][49] particularly among native populations. 4 Genotype D was found in an isolate from an individual who was not native to the community studied and is similar to genotypes found in the Mediterranean and East Africa.…”

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confidence: 99%

Epidemiology and Molecular Characterization of Hepatitis B Virus Infection in Isolated Villages in the Western Brazilian Amazon

Castilho

Oliveira

Gimaque

et al. 2012

The American Journal of Tropical Medicine and Hygiene

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“…Our results may be influenced by the large number of individuals co-infected with HDV at 65.1% (56/86), which spontaneously suppresses HBV [32][33] , as well as problems in handling the samples during field work in precarious places such as the rural Amazon.…”

Section: Ethical Considerationsmentioning

confidence: 97%

Molecular characterization of the hepatitis B virus in autochthonous and endogenous populations in the Western Brazilian Amazon

Dias

Oliveira

Castilho

et al. 2012

Rev. Soc. Bras. Med. Trop.

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INTRODUCTION: Hepatitis B virus (HBV) infection is a serious public health issue worldwide. Hepatitis B virus is classified into eight genotypes, varying from A to H, with distinct geographical distributions. In Brazil, the most frequent genotypes are A, D, and F. METHODS: This study aimed to characterize the HBV genotypes in cases of hepatitis B virus and hepatitis D virus (HDV) co-infections in an endemic area in the Western Brazilian Amazon. We analyzed 86 serum samples reactive for HBsAg from indigenous and non-indigenous populations obtained from previous serological surveys. RESULTS: Of the 86 reactive serum samples, 39 were found to be HBV-DNA-positive by semi-nested PCR. The genotypes were established by sequencing the amplified S gene region. We obtained 20 sequences classified into three genotypes: A, D, and F. Genotype A was the most frequent (60%), followed by D (35%) and F (5%). CONCLUSIONS: The distribution of the HBV genotypes reflected the pattern of historical occupation of the region.

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“…The current Pegylated interferon in advanced delta hepatitis 561 study addresses this issue and compares the efficacy and safety of peg-IFNα 2a-based treatment in CDH-induced advanced liver disease versus in patients with non-advanced disease, through reanalysis of the effective arms of the recently published Hep-Net-International Delta Hepatitis Intervention Trial (HIDIT)-1 Study (11). Further, patients who participated in the study had hepatitis D virus (HDV) genotype I and hepatitis B virus (HBV) genotype D, both of which may be regarded as less favorable viral parameters with regard to treatment response (21,22).…”

Section: Introductionmentioning

confidence: 99%

Pegylated interferon-based treatment in patients with advanced liver disease due to chronic delta hepatitis

Kabaçam

Dalekos²,

Çakalǒglu³

et al. 2012

Turk J Gastroenterol

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Amaç: ‹leri delta hepatitinde interferonlar›n güvenilirlik ve etkinli¤i araflt›r›lmam›flt›r. Çok merkezli bir klinik çal›flman›n bu alt analizinin amac›, kronik delta hepatitine ba¤l› ileri karaci¤er hastal›¤› olan ve ileri hastal›¤› olmayan hasta gruplar›n›, 48 haftal›k interferon alfa-2a (180 μgAnahtar kelimeler: Siroz, hepatitis delta, pegile interferon, tedavi Background/aims: The safety and efficacy of interferons in advanced delta hepatitis have not been explored. The aim of this subanalysis of a multicenter clinical trial was to compare the efficacy and safety of 48 weeks of pegylated interferon alpha-2a (180 μg weekly) with or without adefovir (10 mg daily) in patients with chronic delta hepatitis-induced advanced liver disease and in those with non-advanced liver disease. Materials and Met

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Influence of Hepatitis B Virus (HBV) Genotype on the Clinical Course of Disease in Patients Coinfected with HBV and Hepatitis Delta Virus

Abstract: Liver inflammation and HDV load are influenced by HBV genotype in individuals coinfected with HBV and HDV.

Cited by 50 publications

References 10 publications

Epidemiology and Molecular Characterization of Hepatitis B Virus Infection in Isolated Villages in the Western Brazilian Amazon

Epidemiology and Molecular Characterization of Hepatitis B Virus Infection in Isolated Villages in the Western Brazilian Amazon

Molecular characterization of the hepatitis B virus in autochthonous and endogenous populations in the Western Brazilian Amazon

Pegylated interferon-based treatment in patients with advanced liver disease due to chronic delta hepatitis

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