Influence of hepatic regeneration after partial hepatectomy on theophylline pharmacokinetics in rats

Maza, A. M.; Rodríguez-Gascón, Alicia; Hernández, Rosa María; Solinís, Maria Ángelés; Calvo, Miguel; Pedraz, José Luís

doi:10.1007/bf03190376

Cited by 3 publications

(1 citation statement)

References 20 publications

(15 reference statements)

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“…The influence of hepatic regeneration after partial hepatectomy (removal of median and lateral lobes) on theophylline (Th) pharmacokinetics in groups of five adult male Wistar rats was studied by Maza et al (2001). At 12 and 24 hr and 3, 6, and 15 days after partial hepatectomy, Th was administered intravenously as a single dosage of 6 mg/kg, and plasma concentrations were determined at periodic intervals.…”

Section: Pharmacokineticsmentioning

confidence: 99%

Evaluation of the reproductive and developmental risks of caffeine

Brent

Christian

Diener

2011

Birth Defects Research Pt B

119

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A risk analysis of in utero caffeine exposure is presented utilizing epidemiological studies and animal studies dealing with congenital malformation, pregnancy loss, and weight reduction. These effects are of interest to teratologists, because animal studies are useful in their evaluation. Many of the epidemiology studies did not evaluate the impact of the “pregnancy signal,” which identifies healthy pregnancies and permits investigators to identify subjects with low pregnancy risks. The spontaneous abortion epidemiology studies were inconsistent and the majority did not consider the confounding introduced by not considering the pregnancy signal. The animal studies do not support the concept that caffeine is an abortafacient for the wide range of human caffeine exposures. Almost all the congenital malformation epidemiology studies were negative. Animal pharmacokinetic studies indicate that the teratogenic plasma level of caffeine has to reach or exceed 60 µg/ml, which is not attainable from ingesting large amounts of caffeine in foods and beverages. No epidemiological study described the “caffeine teratogenic syndrome.” Six of the 17 recent epidemiology studies dealing with the risk of caffeine and fetal weight reduction were negative. Seven of the positive studies had growth reductions that were clinically insignificant and none of the studies cited the animal literature. Analysis of caffeine's reproductive toxicity considers reproducibility and plausibility of clinical, epidemiological, and animal data. Moderate or even high amounts of beverages and foods containing caffeine do not increase the risks of congenital malformations, miscarriage or growth retardation. Pharmacokinetic studies markedly improve the ability to perform the risk analyses. Birth Defects Res (Part B) 92:152–187, 2011. © 2011 Wiley-Liss, Inc.

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Section: Pharmacokineticsmentioning

confidence: 99%

Evaluation of the reproductive and developmental risks of caffeine

Brent

Christian

Diener

2011

Birth Defects Research Pt B

119

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Pharmacokinetic changes of unbound theophylline are due to plasma protein binding displacement and CYP1A2 activity inhibition by baicalin in rats

Gao¹,

Fang²,

Qi³

et al. 2013

Journal of Ethnopharmacology

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Pharmacokinetics of drugs in adult living donor liver transplant patients: regulatory factors and observations based on studies in animals and humans

Zhao

Humar³

et al. 2016

Expert Opinion on Drug Metabolism & Toxicology

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It takes up to six months for the liver volume to return to normal after LDLT surgery. In the LDLT recipients, drug exposure generally is higher with lower clearance during early period post-transplant; lower initial dosages of immunosuppressants are used than deceased donor liver transplant recipients during the first six months post-transplantation. In animals, the activities of hepatic drug metabolizing enzymes and transporters are known to be altered differentially during liver regeneration. Future studies on the actual hepatic function with reference to drug metabolism, drug transport, and biliary secretion in both LDLT donors and recipients are required.

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Influence of hepatic regeneration after partial hepatectomy on theophylline pharmacokinetics in rats

Cited by 3 publications

References 20 publications

Evaluation of the reproductive and developmental risks of caffeine

Evaluation of the reproductive and developmental risks of caffeine

Pharmacokinetic changes of unbound theophylline are due to plasma protein binding displacement and CYP1A2 activity inhibition by baicalin in rats

Pharmacokinetics of drugs in adult living donor liver transplant patients: regulatory factors and observations based on studies in animals and humans

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