Influence of Hemofiltration on Plasma Cytokine Levels and Platelet Activation During Extra Corporeal Membrane Oxygenation

Skogby, Maria; Adrian, Katrin; Friberg, Lars Göran; Mellgren, Gösta; Mellgren, Karin

doi:10.1080/713783129

Cited by 15 publications

(14 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For most of these techniques, however, there are insufficient ex vivo data to demonstrate consistent efficacy across studies [24,25,26,27]. …”

Section: Discussionmentioning

confidence: 99%

“…Of these four, UF concentrations were measured in only 3 papers including one which used healthy donor plasma spiked with recombinant interleukin-6 (IL-6) [7], another which simulated therapy during extracorporeal membrane oxygenation [8] and another involving blood withdrawn from adults undergoing hemodialysis (HD) [9]. As a result of this lack of uniformity, the data for UF concentration were not analyzed further and are not displayed here.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Techniques of Extracorporeal Cytokine Removal: A Systematic Review of the Literature

2012

View full text Add to dashboard Cite

Background and Aims: Attempts at achieving cytokine homeostasis include blood purification to deliver cytokine removal. Assessment of ex vivo studies for optimal operating conditions is a vital step. Methods: We conducted a systematic search for ex vivo studies on cytokine removal using known modalities of extracorporeal circulation. We selected 29 articles and analyzed data according to clearance, sieving coefficient, ultrafiltrate concentration and percentage removal. Results: We identified four main techniques for cytokine removal: standard techniques, high cut-off (HCO) techniques, adsorption techniques and combined plasma filtration adsorption. HCO hemofiltration (HCO/HF) showed greatest consistency in cytokine removal among all approaches. Mean albumin clearance with HCO filters was 3.74 ml/min. Conclusion: Ex vivo data support the view that HCO/HF is the most consistently effective approach in terms of sieving and clearance. Further investigation of HCO/HF in randomized controlled trials in animal models and humans seems desirable.

show abstract

“…For most of these techniques, however, there are insufficient ex vivo data to demonstrate consistent efficacy across studies [24,25,26,27]. …”

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Techniques of Extracorporeal Cytokine Removal: A Systematic Review of the Literature

2012

View full text Add to dashboard Cite

show abstract

“…Continuous renal replacement therapy (CRRT) shows remarkable advantages in eliminating inflammatory mediators, dampening inflammatory response, preserving organ function and maintaining optimal fluid status during ECMO with well clinical tolerance in a hemodynamically unstable condition [20-22]. ECMO-associated organ lesion of myocardium and kidney was proven to be extenuated with CRRT [23].…”

Section: Introductionmentioning

confidence: 99%

Effects of continuous renal replacement therapy on intestinal mucosal barrier function during extracorporeal membrane oxygenation in a porcine model

Yang

et al. 2014

J Cardiothorac Surg

View full text Add to dashboard Cite

BackgroundsExtracorporeal membrane oxygenation (ECMO) has been recommended for treatment of acute, potentially reversible, life-threatening respiratory failure unresponsive to conventional therapy. Intestinal mucosal barrier dysfunction is one of the most critical pathophysiological disorders during ECMO. This study aimed to determine whether combination with CRRT could alleviate damage of intestinal mucosal barrier function during VV ECMO in a porcine model.MethodsTwenty-four piglets were randomly divided into control(C), sham(S), ECMO(E) and ECMO + CRRT(EC) group. The animals were treated with ECMO or ECMO + CRRT for 24 hours. After the experiments, piglets were sacrificed. Jejunum, ileum and colon were harvested for morphologic examination of mucosal injury and ultrastructural distortion. Histological scoring was assessed according to Chiu’s scoring standard. Blood samples were taken from the animals at -1, 2, 6, 12 and 24 h during experiment. Blood, liver, spleen, kidney and mesenteric lymphnode were collected for bacterial culture. Serum concentrations of diamine oxidase (DAO) and intestinal fatty acid binding protein (I-FABP) were tested as markers to assess intestinal epithelial function and permeability. DAO levels were determined by spectrophotometry and I-FABP levels by enzyme linked immunosorbent assay.ResultsMicroscopy findings showed that ECMO-induced intestinal microvillus shedding and edema, morphological distortion of tight junction between intestinal mucous epithelium and loose cell-cell junctions were significantly improved with combination of CRRT. No significance was detected on positive rate of serum bacterial culture. The elevated colonies of bacterial culture in liver and mesenteric lymphnode in E group reduced significantly in EC group (p < 0.05). Compared with E group, EC group showed significantly decreased level of serum DAO and I-FABP (p < 0.05).ConclusionsCRRT can alleviate the intestinal mucosal dysfunction and bacterial translocation during VV ECMO, which may extenuate the ECMO-associated SIRS and raise the clinical effect and safety.

show abstract

“…The preferential BAL cytokine expression reported in our trial is similar to a report of greater expression of TNF-α, IL-6, and IL-8 from alveolar leukocytes than plasma leukocytes in humans on CPB for ~2 h. Of the cytokines studied, IL-8 gene expression was greater in lung tissue than plasma, reflecting the degree of pulmonary dysfunction (23). In contrast, a 24-h in vitro ECMO run using pooled human blood demonstrated elevations in plasma IL-6 and IL-8 levels, but by design no BAL/tissue specimens were available for comparison (22).…”

Section: Discussionmentioning

confidence: 96%

Continuous renal replacement therapy to reduce inflammation in a piglet hemorrhage–reperfusion extracorporeal membrane oxygenation model

Palmer

Batts

et al. 2012

Pediatr Res

View full text Add to dashboard Cite

Influence of Hemofiltration on Plasma Cytokine Levels and Platelet Activation During Extra Corporeal Membrane Oxygenation

Cited by 15 publications

References 0 publications

Techniques of Extracorporeal Cytokine Removal: A Systematic Review of the Literature

Techniques of Extracorporeal Cytokine Removal: A Systematic Review of the Literature

Effects of continuous renal replacement therapy on intestinal mucosal barrier function during extracorporeal membrane oxygenation in a porcine model

Continuous renal replacement therapy to reduce inflammation in a piglet hemorrhage–reperfusion extracorporeal membrane oxygenation model

Contact Info

Product

Resources

About