Influence of Graded Arterial Pressure Decrement on Renal Clearance of Creatinine, P-Aminohippurate and Sodium

A Study of the Mechanisms of Edema Formation in Patients with the Nephrotic Syndrome 1

“…A lesser reduction in GFR can be induced in man by passive tilting (33,34); this induces the same disproportionately large decrease in water and salt excretion in man as is found in dogs after GFR is decreased by reduction in renal arterial pressure (8)(9)(10)(11). A similar relationship of sodium excretion to Cer was illustrated in Figure 2.…”

“…The term "Decrease in filtering surface" is intended to apply to both of these circumstances. 8 and VEEC is the volume of red cells (assumed constant) calculated from the T-1824 volume and hematocrit measured on day 11. studies described in the present report and in the preceding papers of the series (16,17,65 Figure 14. During each hospital admission the diet was kept nearly constant with respect to protein (40 to 50 Gm.…”

“…Most measurements were made before, during, and after periods of diuresis which were either spontaneous or induced by administration of concentrated human plasma albumin. 5 Because small changes in the glomerular filtration rate can result in disproportionately large changes in salt and water excretion (8)(9)(10)(11), the technic of around-the-clock clearances, in which measurements are made in successive clearance periods continuing over one or more days, was frequently used.…”

Hypernatremia. Complication of renal homotransplantation

“…16 Although none of our patients exhibited definite clinical manifestations of acute homograft rejection, the fact that the creatinine clearance values, which were initially relatively low, assumed higher rates during further postoperative course is consistent with an early state of renal underperfusion.…”

Intrarenal Vascular Sites of Action of Adenosine and Glucagon

“…Renal autoregulation is a well-established physiological phenomenon in which RBF and GFR remain relatively con stant over a wide range of perfusion pressures through changes in the resistance of the af ferent arteriole (10)(11)(12)(13)(14)(15). Also, it is generally accepted that the resistance of the pre glomerular vessels attains a minimum value at the renal perfusion pressure (RPP) near the lower limit of the autoregulatory pressure range (14,15).…”