Influence of Glycemic Status and Physical Fitness on Oxidative Stress and the Peroxiredoxin System in the Erythrocytes of Non-Insulin-Dependent Type 2 Diabetic Men

Brinkmann, Christian; Neumann, Eylon; Blossfeld, Jenny; Frese, Sebastian; Orthmann, P.; Montiel, Georgina; Bloch, Wilhelm; Brixius, Klara

doi:10.1055/s-0031-1279712

Cited by 9 publications

(6 citation statements)

References 22 publications

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“…Previous studies in patients with T2DM revealed a decrease in antioxidant defense mechanisms and an increase in markers of oxidative damage, especially in patients with diabetes-related complications ( 9 ). Similar results to ours were reported for PRDX1 activity in erythrocytes, which was greater in T2DM patients than in non-diabetic subjects ( 12 ). Another study revealed a high total antioxidant capacity and higher concentrations of lipid peroxidation markers in T2DM patients than in non-diabetic subjects ( 13 ).…”

Section: Discussionsupporting

confidence: 92%

Peroxiredoxin isoforms are associated with cardiovascular risk factors in type 2 diabetes mellitus

Eter

Al-Masri

2015

Braz J Med Biol Res

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The production of oxygen free radicals in type 2 diabetes mellitus contributes to the development of complications, especially the cardiovascular-related ones. Peroxiredoxins (PRDXs) are antioxidant enzymes that combat oxidative stress. The aim of this study was to investigate the associations between the levels of PRDX isoforms (1, 2, 4, and 6) and cardiovascular risk factors in type 2 diabetes mellitus. Fifty-three patients with type 2 diabetes mellitus (28F/25M) and 25 healthy control subjects (7F/18M) were enrolled. We measured the plasma levels of each PRDX isoform and analyzed their correlations with cardiovascular risk factors. The plasma PRDX1, -2, -4, and -6 levels were higher in the diabetic patients than in the healthy control subjects. PRDX2 and -6 levels were negatively correlated with diastolic blood pressure, fasting blood sugar, and hemoglobin A1c. In contrast, PRDX1 levels were positively correlated with low-density lipoprotein and C-reactive protein levels. PRDX4 levels were negatively correlated with triglycerides. In conclusion, PRDX1, -2, -4, and -6 showed differential correlations with a variety of traditional cardiovascular risk factors. These results should encourage further research into the crosstalk between PRDX isoforms and cardiovascular risk factors.

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Section: Discussionsupporting

confidence: 92%

Peroxiredoxin isoforms are associated with cardiovascular risk factors in type 2 diabetes mellitus

Eter

Al-Masri

2015

Braz J Med Biol Res

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“…Several epidemiological studies with relatively small sample sizes have evaluated the associations of urinary 8-iso-PGF2a and 8-OHdG with blood glucose. A cross-sectional study conducted on 76 Indian Mauritians showed a positive relationship between 8-iso-PGF2a and FPG (31), and similar results were also found by Brinkmann et al (32) and Altomare et al (33). Also, Rytter et al (34) investigated 56 Swedish patients with diabetes and found that urinary 8-iso-PGF2a, but not 8-OHdG, was positively associated with blood glucose.…”

Section: Discussionsupporting

confidence: 79%

Acrylamide Exposure and Oxidative DNA Damage, Lipid Peroxidation, and Fasting Plasma Glucose Alteration: Association and Mediation Analyses in Chinese Urban Adults

et al. 2020

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Acrylamide exposure from daily-consumed food has raised global concern. We aimed to assess the exposure-response relationships of internal acrylamide exposure with oxidative DNA damage, lipid peroxidation, and fasting plasma glucose (FPG) alteration and investigate the mediating role of oxidative DNA damage and lipid peroxidation in the association of internal acrylamide exposure with FPG. RESEARCH DESIGN AND METHODSFPG and urinary biomarkers of oxidative DNA damage (8-hydroxy-deoxyguanosine [8-OHdG]), lipid peroxidation (8-iso-prostaglandin-F2a [8-iso-PGF2a]), and acrylamide exposure (N-acetyl-S-) were measured for 3,270 general adults from the Wuhan-Zhuhai cohort. The associations of urinary acrylamide metabolites with 8-OHdG, 8-iso-PGF2a, and FPG were assessed by linear mixed models. The mediating roles of 8-OHdG and 8-iso-PGF2a were evaluated by mediation analysis. RESULTSWe found significant linear positive dose-response relationships of urinary acrylamide metabolites with 8-OHdG, 8-iso-PGF2a, and FPG (except GAMA with FPG) and 8-iso-PGF2a with FPG. Each 1-unit increase in log-transformed level of AAMA, AAMA 1 GAMA (SUAAM), or 8-iso-PGF2a was associated with a 0.17, 0.15, or 0.23 mmol/L increase in FPG, respectively (P and/or P trend < 0.05). Each 1% increase in AAMA, GAMA, or SUAAM was associated with a 0.19%, 0.27%, or 0.22% increase in 8-OHdG, respectively, and a 0.40%, 0.48%, or 0.44% increase in 8-iso-PGF2a, respectively (P and P trend < 0.05). Increased 8-iso-PGF2a rather than 8-OHdG significantly mediated 64.29% and 76.92% of the AAMA-and SUAAMassociated FPG increases, respectively. CONCLUSIONSExposure of the general adult population to acrylamide was associated with FPG elevation, oxidative DNA damage, and lipid peroxidation, which in turn partly mediated acrylamide-associated FPG elevation.

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“…One of the mechanisms suspected to be at the origin of the RBC deformability improvement in healthy individuals is the greater RBC-NOS activation and RBC NO production noted in response to exercise 16 . In addition, long term training is associated to a reduction in free radical production and improved antioxidant capacity in healthy people and subjects with metabolic diseases 25,26 . In SCA, the metabolic changes that occur during acute exercise, including increased free radical production, can promote HbS polymerization and RBC sickling.…”

Section: Introductionmentioning

confidence: 99%

Effect of acute exercise on RBC deformability and RBC nitric oxide synthase signalling pathway in young sickle cell anaemia patients

Grau

Jerke

Nader

et al. 2019

Sci Rep

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Sickle cell anaemia (SCA) is characterized by reduced red blood cell (RBC) deformability and nitric oxide (NO) bioavailability. The aim of the study was to investigate whether exercise might affect these parameters in SCA. SCA patients and healthy controls (AA) performed an acute submaximal exercise test until subjects reached the first ventilatory threshold (VT 1). Blood was sampled at rest and at VT 1. At rest, free haemoglobin level was higher and RBC count, haemoglobin and haematocrit were lower in SCA compared to AA. RBC deformability was lower in SCA. Exercise had no effect on the tested parameters. RBC NO level was higher in SCA compared to AA at rest and significantly decreased after exercise in SCA. This might be related to a reduction in RBC-NO synthase (RBC-NOS) activation which was only observed in SCA after exercise. Free radical levels were higher in SCA at rest but concentration was not affected by exercise. Marker for lipid peroxidation and antioxidative capacity were similar in SCA and AA and not affected by exercise. In conclusion, a single acute submaximal bout of exercise has no deleterious effects on RBC deformability or oxidative stress markers in SCA, and seems to modulate RBC-NOS signalling pathway.

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Influence of Glycemic Status and Physical Fitness on Oxidative Stress and the Peroxiredoxin System in the Erythrocytes of Non-Insulin-Dependent Type 2 Diabetic Men

Cited by 9 publications

References 22 publications

Peroxiredoxin isoforms are associated with cardiovascular risk factors in type 2 diabetes mellitus

Peroxiredoxin isoforms are associated with cardiovascular risk factors in type 2 diabetes mellitus

Acrylamide Exposure and Oxidative DNA Damage, Lipid Peroxidation, and Fasting Plasma Glucose Alteration: Association and Mediation Analyses in Chinese Urban Adults

Effect of acute exercise on RBC deformability and RBC nitric oxide synthase signalling pathway in young sickle cell anaemia patients

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